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Fetal exposure to m...
Fetal exposure to maternal cigarette smoking and male reproductive function in young adulthood
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- Hærvig, Katia Keglberg (författare)
- Copenhagen University Hospital
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- Petersen, Kajsa Ugelvig (författare)
- Copenhagen University Hospital
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- Giwercman, Aleksander (författare)
- Lund University,Lunds universitet,Molekylärgenetisk reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproduktionsmedicin, Malmö,Molecular genetic reproductive medicine, Malmö,Lund University Research Groups,Reproductive medicine, Malmö
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- Hougaard, Karin Sørig (författare)
- University of Copenhagen,The National Research Centre for the Working Environment
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- Høyer, Birgit Bjerre (författare)
- Copenhagen University Hospital
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- Lindh, Christian (författare)
- Lund University,Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
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- Ramlau-Hansen, Cecilia Høst (författare)
- Aarhus University
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- Nybo Andersen, Anne Marie (författare)
- University of Copenhagen
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- Toft, Gunnar (författare)
- Aarhus University Hospital
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- Bonde, Jens Peter (författare)
- University of Copenhagen,Copenhagen University Hospital
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- Tøttenborg, Sandra Søgaard (författare)
- Copenhagen University Hospital,University of Copenhagen
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(creator_code:org_t)
- 2022-04-27
- 2022
- Engelska 14 s.
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Ingår i: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 37:5, s. 525-538
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Maternal smoking during pregnancy constitutes a potential, major risk factor for adult male reproductive function. In the hitherto largest longitudinal cohort, we examined biomarkers of reproductive function according to maternal smoking during the first trimester and investigated whether associations were mitigated by smoking cessation prior to the fetal masculinization programming window. Associations between exposure to maternal smoking and semen characteristics, testicular volume and reproductive hormones were assessed among 984 young men from the Fetal Programming of Semen Quality (FEPOS) cohort. Maternal smoking was assessed through interview data and measured plasma cotinine levels during pregnancy. We applied negative binomial, logistic and linear regression models to estimate differences in outcomes according to levels of maternal smoking. Sons of light smokers (≤ 10 cigarettes/day) had a 19% (95% CI − 29%, − 6%) lower sperm concentration and a 24% (95% CI − 35%, − 11%) lower total sperm count than sons of non-smokers. These estimates were 38% (95% CI − 52%, − 22%) and 33% (95% CI − 51%, − 8%), respectively, for sons of heavy smokers (> 10 cigarettes/day). The latter group also had a 25% (95% CI 1%, 54%) higher follitropin level. Similarly, sons exposed to maternal cotinine levels of > 10 ng/mL had lower sperm concentration and total sperm count. Smoking cessation prior to gestational week seven was not associated with a higher reproductive capacity. We observed substantial and consistent exposure–response associations, providing strong support for the hypothesis that maternal smoking impairs male reproductive function. This association persisted regardless of smoking cessation in early pregnancy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Fetal programming
- Male infertility
- Maternal smoking
- Prenatal exposure
- Reproductive hormones
- Semen quality
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Hærvig, Katia Ke ...
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Petersen, Kajsa ...
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Giwercman, Aleks ...
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Hougaard, Karin ...
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Høyer, Birgit Bj ...
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Lindh, Christian
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Ramlau-Hansen, C ...
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Nybo Andersen, A ...
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Toft, Gunnar
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Bonde, Jens Pete ...
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Tøttenborg, Sand ...
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