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Maternal hormones during early pregnancy : a cross-sectional study
- Chen, Tianhui (author)
-
- Lundin, Eva (author)
- Umeå universitet,Patologi
-
- Grankvist, Kjell (author)
- Umeå universitet,Klinisk kemi
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- Zeleniuch-Jacquotte, Anne (author)
- Afanasyeva, Yelena (author)
- Schock, Helena (author)
- Toniolo, Paolo (author)
- Lukanova, Annekatrin (author)
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- (creator_code:org_t)
- 2010-01-19
- 2010
- English.
- In: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 0957-5243 .- 1573-7225. ; 21:5, s. 719-727
- Journal article (peer-reviewed)
Abstract
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- BACKGROUND: Little is known about correlates of first-trimester pregnancy hormones as in most studies maternal hormones have been measured later in gestation. We examined the associations of maternal characteristics and child sex with first-trimester maternal concentrations of four hormones implicated in breast cancer: human chorionic gonadotropin (hCG), alpha-fetoprotein (AFP), insulin-like growth factor (IGF)-I, and IGF-II. METHODS: About 338 serum samples donated to the Northern Sweden Maternity Cohort (NSMC), 1975-2001, during the first trimester of uncomplicated pregnancies, were analyzed for the hormones of interest as a part of a case-control study. The associations of maternal characteristics and child sex with hormone concentrations were investigated by correlation, general linear regression, and multivariate regression models. RESULTS: In the first trimester, greater maternal age was inversely correlated with IGF-I and IGF-II. In comparison with women carrying their first child, already parous women had higher IGF-I but lower hCG. Greater maternal weight and smoking were inversely correlated with hCG. No differences in hormone levels by child sex were observed. CONCLUSIONS: Our analyses indicated that potentially modifiable maternal characteristics (maternal weight and smoking) influence first-trimester pregnancy maternal hormone concentrations.
Keyword
- Pregnancy
- Cross-sectional study
- Human chorionic gonadotropin (hCG)
- α-Fetoprotein (AFP)
- Insulin-like growth factor (IGF)-I
- IGF-II
Publication and Content Type
- ref (subject category)
- art (subject category)
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