Sökning: WFRF:(Hanson J)
> (1995-1999) >
IL-10-driven immuno...
IL-10-driven immunoglobulin production by B lymphocytes from IgA-deficient individuals correlates to infection proneness.
-
- Friman, Vanda, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases
-
- Hanson, Lars Åke, 1934 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi,Institute of Laboratory Medicine, Dept of Clinical Immunology
-
Bridon, J M (författare)
-
visa fler...
-
- Tarkowski, Andrej, 1951 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
-
Banchereau, J (författare)
-
Brière, F (författare)
-
visa färre...
-
(creator_code:org_t)
- 1996
- 1996
- Engelska.
-
Ingår i: Clinical and experimental immunology. - 0009-9104. ; 104:3, s. 432-8
- Relaterad länk:
-
https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- In search for a possible explanation of the phenotypic heterogeneity in IgA deficiency, we studied the function of B cells from IgA-deficient (IgAd) individuals. Two groups of IgAd individuals, one frequently infected and one clinically apparently healthy, as well as normal controls, were studied. Peripheral blood mononuclear cells (PBMC) and B cells from IgAd individuals and controls were cultured with Staphylococcus aureus Cowan I strain and with anti-CD40 MoAb presented on the CD32-transfected fibroblast cell line in the presence of IL-10. In this experimental system PBMC and B cells from the infection-prone IgAd individuals produced only minute amounts of IgA. In contrast, PBMC and B cells from healthy IgAd subjects secreted significantly more IgA1 and IgA2 in comparison with infection-prone IgAd patients (P < 0.05). These data suggest that the abnormalities of B cell differentiation in IgAd could be of heterogeneous origin. Thus, whereas in healthy IgAd subjects IgA production may be efficiently up-regulated in vitro by addition of IL-10 to CD40-activated B cell culture, the corresponding B cell differentiation does not occur in infection-prone IgAd patients. These observations provide a conceptual framework for phenotypic heterogeneity in IgAd subjects.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Adult
- Antibodies
- Monoclonal
- immunology
- Antibody Formation
- B-Lymphocytes
- immunology
- CD40 Antigens
- immunology
- Cells
- Cultured
- Coculture Techniques
- Culture Media
- analysis
- Dysgammaglobulinemia
- immunology
- Enzyme-Linked Immunosorbent Assay
- Female
- Fibroblasts
- Humans
- IgA Deficiency
- immunology
- Immunoglobulin A
- analysis
- biosynthesis
- Immunoglobulin G
- analysis
- biosynthesis
- Immunoglobulin M
- analysis
- biosynthesis
- Interleukin-10
- genetics
- immunology
- Leukocytes
- Mononuclear
- immunology
- Lymphocyte Activation
- Male
- Middle Aged
- Recombinant Proteins
- immunology
- Respiratory Tract Infections
- immunology
- Staphylococcal Infections
- immunology
- Staphylococcus aureus
- Transfection
- Up-Regulation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas