Radiotherapy-induced vascular cognitive impairment 20 years after childhood brain tumor

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Harila Arja) > Radiotherapy-induce...

Radiotherapy-induced vascular cognitive impairment 20 years after childhood brain tumor

Remes, Tiina Maria (author): Kivela City Hosp Helsinki, POB 6100, Helsinki 00099, Finland.;Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.

Suo-Palosaari, Maria Helena (author): Oulu Univ Hosp, Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol,Dept Diagnost, Oulu, Finland.

Arikoski, Pekka Matti (author): Univ Eastern Finland, Kuopio Univ Hosp, Kuopio Pediat Res Unit, Kuopio, Finland.

Harila, Marika (author): Univ Oulu, Oulu Univ Hosp, Dept Neurol, Oulu, Finland.

Koskenkorva, Paeivi Katri Tuulikki (author): Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland.

Lahteenmaki, Paivi Maria (author): Turku Univ, Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland.

Lonnqvist, Tuula Riitta Irmeli (author): Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.

Ojaniemi, Marja Katariina (author): Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.

Pohjasniemi, Heli (author)

Puosi, Riina (author): Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.

Ritari, Niina (author): Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.

Sirkia, Kirsti Helena (author): Univ Helsinki, Helsinki Univ Hosp, Dept Pediat & Adolescence, Helsinki, Finland.

Sutela, Anna Kaarina (author): Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland.

Toiviainen-Salo, Sanna-Maria (author): Univ Helsinki, Helsinki Univ Hosp, HUS Med Imaging Ctr, Dept Pediat Radiol, Helsinki, Finland.

Rantala, Heikki Markku Johannes (author): Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.

Harila, Arja (author): Uppsala universitet,Barnonkologisk och neurologisk forskning

show less...

Kivela City Hosp Helsinki, POB 6100, Helsinki 00099, Finland;Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland. Oulu Univ Hosp, Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol,Dept Diagnost, Oulu, Finland. (creator_code:org_t)

Oxford University Press, 2024
2024
English.
In: Neuro-Oncology. - : Oxford University Press. - 1522-8517 .- 1523-5866. ; 26:2, s. 362-373

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Studies have established that radiotherapy for childhood brain tumors (BTs) increases the risk of cerebrovascular disease (CVD); however, it is unclear how this will affect cognitive function. This study aimed to investigate the associations between radiotherapy-induced CVD, white matter hyperintensities (WMHs), and neurocognitive outcomes in adult survivors of childhood BTs.Methods: In a cross-sectional setting, we conducted a national cohort that included 68 radiotherapy-treated survivors of childhood BTs after a median follow-up of 20 years. Markers of CVD and WMHs were evaluated using brain MRI, and the sum of CVD-related findings was calculated. Additionally, the associations among CVD findings, WMHs, and neuropsychological test results were analyzed.Results: Of the 68 childhood BT survivors, 54 (79%) were diagnosed with CVD and/or WMHs at a median age of 27 years. CVD and/or WMHs were associated with lower scores for verbal intelligence quotient, performance intelligence quotient (PIQ), executive function, memory, and visuospatial ability (P < .05). Additionally, survivors with microbleeds had greater impairments in the PIQ, processing speed, executive function, and visuospatial ability (P < .05). WMHs and CVD burden were associated with greater difficulties in memory function and visuospatial ability (P < .05). Small-vessel disease burden was associated with PIQ scores, processing speed, working memory, and visuospatial ability.Conclusions: The study results suggest that markers of radiotherapy-induced CVD, the additive effect of CVD markers, and risk factors of dementia are associated with cognitive impairment, which may suggest that the survivors are at a high risk of developing early-onset dementia.

Find in a library

Neuro-Oncology (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Remes, Tiina Mar ...; Suo-Palosaari, M ...; Arikoski, Pekka ...; Harila, Marika; Koskenkorva, Pae ...; Lahteenmaki, Pai ...; show more...; Lonnqvist, Tuula ...; Ojaniemi, Marja ...; Pohjasniemi, Hel ...; Puosi, Riina; Ritari, Niina; Sirkia, Kirsti H ...; Sutela, Anna Kaa ...; Toiviainen-Salo, ...; Rantala, Heikki ...; Harila, Arja; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

Articles in the publication: Neuro-Oncology

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Radiotherapy-induced vascular cognitive impairment 20 years after childhood brain tumor

Subject headings

Keyword

Publication and Content Type

Find in a library

To the university's database

Find more in SwePub

Search outside SwePub