Enterovirus infection may induce humoral immune response reacting with islet cell autoantigens in humans

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Fältnamn	Indikatorer	Metadata
000		03348naa a2200433 4500
001		oai:DiVA.org:liu-47820
003		SwePub
008		091011s2003 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-478202 URI
024	7	a https://doi.org/10.1002/jmv.103062 DOI
040		a (SwePub)liu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Harkonen, T4 aut
245	1 0	a Enterovirus infection may induce humoral immune response reacting with islet cell autoantigens in humans
264		c 2003-01-13
264	1	b Wiley,c 2003
338		a print2 rdacarrier
520		a Molecular mimicry is one of the mechanisms by which enterovirus infections have been postulated to have a role in the pathogenesis of type 1 diabetes. Immunogenic epitopes in enterovirus capsid protein VP1 and procapsid protein VP0 have sequence similarities with diabetes-associated epitopes in tyrosine phosphatase IA-2/IAR and heat shock protein 60. In the present study, documented enterovirus infection was shown to induce humoral responses, that in 7% and 1% of patients cross-reacted with the known diabetes-associated epitopes in tyrosine phosphatase IAR and heat shock protein 60, respectively. In contrast, none of the children vaccinated against poliomyelitis had antibodies to the diabetes-associated epitope of tyrosine phosphatases IA-2/IAR. The antibody response studied in serum samples from six patients with coxsackievirus A9 infection was mainly targeted to capsid protein VP1. Coxsackievirus A9 infection induced antibodies cross-reacted with one epitope in heat shock protein 60, but not with epitopes derived from other autoantigens. Most diabetic children had high levels of antibodies to both coxsackievirus and poliovirus derived VP1 peptides but the pattern of reactivity did not differ from that seen in healthy children. The reactivity of linear epitopes derived from autoantigens was low in general and associated with the presence of multiple autoantibodies in the patients. Some linear auto-epitopes derived from tyrosine phosphatase IA-2, glutamic acid decarboxylase 65, preproinsulin, and heat shock protein 60 were recognized by sera from diabetic patients, but not by sera from healthy children. In conclusion, enteroviruses may induce immune responses that react with islet cell autoantigens, which is a concern when a putative inactivated enterovirus vaccine is considered.
653		a enterovirus
653		a coxsackievirus
653		a enterovirus infection
653		a poliovirus vaccination
653		a insulin-dependent diabetes mellitus
653		a beta-cell autoantigens
653		a cross-reactive epitopes
653		a MEDICINE
653		a MEDICIN
700	1	a Paananen, A4 aut
700	1	a Lankinen, H4 aut
700	1	a Hovi, T4 aut
700	1	a Vaarala, Outiu Linköpings universitet,Hälsouniversitetet,Pediatrik4 aut0 (Swepub:liu)outva41
700	1	a Roivainen, M4 aut
710	2	a Linköpings universitetb Hälsouniversitetet4 org
773	0	t Journal of Medical Virologyd : Wileyg 69:3, s. 426-440q 69:3<426-440x 0146-6615x 1096-9071
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-47820
856	4 8	u https://doi.org/10.1002/jmv.10306

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Av författaren/redakt...: Harkonen, T; Paananen, A; Lankinen, H; Hovi, T; Vaarala, Outi; Roivainen, M

Artiklar i publikationen: Journal of Medic ...

Av lärosätet: Linköpings universitet

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