Sökning: WFRF:(Haxhija Zana) > The association of ...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 06761naa a2200733 4500 | |
001 | oai:lup.lub.lu.se:6dcd8c5d-9ec0-4fbf-bf85-67f2ead85c45 | |
003 | SwePub | |
008 | 200728s2020 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:144269816 | |
024 | 7 | a https://lup.lub.lu.se/record/6dcd8c5d-9ec0-4fbf-bf85-67f2ead85c452 URI |
024 | 7 | a https://doi.org/10.1186/s13049-020-00760-72 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1442698162 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Ebner, Florianu Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Helsingborg Hospital4 aut0 (Swepub:lu)med-foe |
245 | 1 0 | a The association of partial pressures of oxygen and carbon dioxide with neurological outcome after out-of-hospital cardiac arrest : an explorative International Cardiac Arrest Registry 2.0 study |
264 | c 2020-07-14 | |
264 | 1 | b Springer Science and Business Media LLC,c 2020 |
520 | a BACKGROUND: Exposure to extreme arterial partial pressures of oxygen (PaO2) and carbon dioxide (PaCO2) following the return of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest (OHCA) is common and may affect neurological outcome but results of previous studies are conflicting.METHODS: Exploratory study of the International Cardiac Arrest Registry (INTCAR) 2.0 database, including 2162 OHCA patients with ROSC in 22 intensive care units in North America and Europe. We tested the hypothesis that exposure to extreme PaO2 or PaCO2 values within 24 h after OHCA is associated with poor neurological outcome at discharge. Our primary analyses investigated the association between extreme PaO2 and PaCO2 values, defined as hyperoxemia (PaO2 > 40 kPa), hypoxemia (PaO2 < 8.0 kPa), hypercapnemia (PaCO2 > 6.7 kPa) and hypocapnemia (PaCO2 < 4.0 kPa) and neurological outcome. The secondary analyses tested the association between the exposure combinations of PaO2 > 40 kPa with PaCO2 < 4.0 kPa and PaO2 8.0-40 kPa with PaCO2 > 6.7 kPa and neurological outcome. To define a cut point for the onset of poor neurological outcome, we tested a model with increasing and decreasing PaO2 levels and decreasing PaCO2 levels. Cerebral Performance Category (CPC), dichotomized to good (CPC 1-2) and poor (CPC 3-5) was used as outcome measure.RESULTS: Of 2135 patients eligible for analysis, 700 were exposed to hyperoxemia or hypoxemia and 1128 to hypercapnemia or hypocapnemia. Our primary analyses did not reveal significant associations between exposure to extreme PaO2 or PaCO2 values and neurological outcome (P = 0.13-0.49). Our secondary analyses showed no significant associations between combinations of PaO2 and PaCO2 and neurological outcome (P = 0.11-0.86). There was no PaO2 or PaCO2 level significantly associated with poor neurological outcome. All analyses were adjusted for relevant co-variates.CONCLUSIONS: Exposure to extreme PaO2 or PaCO2 values in the first 24 h after OHCA was common, but not independently associated with neurological outcome at discharge. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng |
653 | a Aged | |
653 | a Arterial Pressure/physiology | |
653 | a Blood Gas Analysis/methods | |
653 | a Carbon Dioxide/analysis | |
653 | a Cardiopulmonary Resuscitation/methods | |
653 | a Europe | |
653 | a Female | |
653 | a Humans | |
653 | a Hypercapnia/diagnosis | |
653 | a Intensive Care Units | |
653 | a Male | |
653 | a Middle Aged | |
653 | a Out-of-Hospital Cardiac Arrest/complications | |
653 | a Oxygen/analysis | |
653 | a Partial Pressure | |
653 | a Registries | |
700 | 1 | a Riker, Richard R.u Maine Medical Center4 aut |
700 | 1 | a Haxhija, Zanau Maine Medical Center4 aut |
700 | 1 | a Seder, David B.u Maine Medical Center4 aut |
700 | 1 | a May, Teresa L.u Maine Medical Center4 aut |
700 | 1 | a Ullén, Susannu Skåne University Hospital4 aut0 (Swepub:lu)su7040ul |
700 | 1 | a Stammet, Pascalu National Fire and Rescue Corps4 aut |
700 | 1 | a Hirsch, Karenu Stanford University4 aut |
700 | 1 | a Forsberg, Suneu Karolinska Institutet,Karolinska Institute,Norrtälje Hospital4 aut |
700 | 1 | a Dupont, Allisonu Heart Center of Northeast Georgia Medical Center4 aut |
700 | 1 | a Friberg, Hansu Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)efor-hfr |
700 | 1 | a McPherson, John A.u Vanderbilt University4 aut |
700 | 1 | a Søreide, Eldaru University of Bergen,Stavanger University Hospital4 aut |
700 | 1 | a Dankiewicz, Josefu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-jfd |
700 | 1 | a Cronberg, Tobiasu Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)efor-tcr |
700 | 1 | a Nielsen, Niklasu Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups,Helsingborg Hospital4 aut0 (Swepub:lu)med-nni |
710 | 2 | a Anestesiologi och intensivvårdb Sektion II4 org |
773 | 0 | t Scandinavian Journal of Trauma, Resuscitation and Emergency Medicined : Springer Science and Business Media LLCg 28:1, s. 67-67q 28:1<67-67x 1757-7241 |
856 | 4 | u http://dx.doi.org/10.1186/s13049-020-00760-7x freey FULLTEXT |
856 | 4 | u https://sjtrem.biomedcentral.com/track/pdf/10.1186/s13049-020-00760-7 |
856 | 4 8 | u https://lup.lub.lu.se/record/6dcd8c5d-9ec0-4fbf-bf85-67f2ead85c45 |
856 | 4 8 | u https://doi.org/10.1186/s13049-020-00760-7 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:144269816 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.