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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006761naa a2200733 4500
001oai:lup.lub.lu.se:6dcd8c5d-9ec0-4fbf-bf85-67f2ead85c45
003SwePub
008200728s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:144269816
0247 a https://lup.lub.lu.se/record/6dcd8c5d-9ec0-4fbf-bf85-67f2ead85c452 URI
0247 a https://doi.org/10.1186/s13049-020-00760-72 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1442698162 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Ebner, Florianu Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Helsingborg Hospital4 aut0 (Swepub:lu)med-foe
2451 0a The association of partial pressures of oxygen and carbon dioxide with neurological outcome after out-of-hospital cardiac arrest : an explorative International Cardiac Arrest Registry 2.0 study
264 c 2020-07-14
264 1b Springer Science and Business Media LLC,c 2020
520 a BACKGROUND: Exposure to extreme arterial partial pressures of oxygen (PaO2) and carbon dioxide (PaCO2) following the return of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest (OHCA) is common and may affect neurological outcome but results of previous studies are conflicting.METHODS: Exploratory study of the International Cardiac Arrest Registry (INTCAR) 2.0 database, including 2162 OHCA patients with ROSC in 22 intensive care units in North America and Europe. We tested the hypothesis that exposure to extreme PaO2 or PaCO2 values within 24 h after OHCA is associated with poor neurological outcome at discharge. Our primary analyses investigated the association between extreme PaO2 and PaCO2 values, defined as hyperoxemia (PaO2 > 40 kPa), hypoxemia (PaO2 < 8.0 kPa), hypercapnemia (PaCO2 > 6.7 kPa) and hypocapnemia (PaCO2 < 4.0 kPa) and neurological outcome. The secondary analyses tested the association between the exposure combinations of PaO2 > 40 kPa with PaCO2 < 4.0 kPa and PaO2 8.0-40 kPa with PaCO2 > 6.7 kPa and neurological outcome. To define a cut point for the onset of poor neurological outcome, we tested a model with increasing and decreasing PaO2 levels and decreasing PaCO2 levels. Cerebral Performance Category (CPC), dichotomized to good (CPC 1-2) and poor (CPC 3-5) was used as outcome measure.RESULTS: Of 2135 patients eligible for analysis, 700 were exposed to hyperoxemia or hypoxemia and 1128 to hypercapnemia or hypocapnemia. Our primary analyses did not reveal significant associations between exposure to extreme PaO2 or PaCO2 values and neurological outcome (P = 0.13-0.49). Our secondary analyses showed no significant associations between combinations of PaO2 and PaCO2 and neurological outcome (P = 0.11-0.86). There was no PaO2 or PaCO2 level significantly associated with poor neurological outcome. All analyses were adjusted for relevant co-variates.CONCLUSIONS: Exposure to extreme PaO2 or PaCO2 values in the first 24 h after OHCA was common, but not independently associated with neurological outcome at discharge.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng
653 a Aged
653 a Arterial Pressure/physiology
653 a Blood Gas Analysis/methods
653 a Carbon Dioxide/analysis
653 a Cardiopulmonary Resuscitation/methods
653 a Europe
653 a Female
653 a Humans
653 a Hypercapnia/diagnosis
653 a Intensive Care Units
653 a Male
653 a Middle Aged
653 a Out-of-Hospital Cardiac Arrest/complications
653 a Oxygen/analysis
653 a Partial Pressure
653 a Registries
7001 a Riker, Richard R.u Maine Medical Center4 aut
7001 a Haxhija, Zanau Maine Medical Center4 aut
7001 a Seder, David B.u Maine Medical Center4 aut
7001 a May, Teresa L.u Maine Medical Center4 aut
7001 a Ullén, Susannu Skåne University Hospital4 aut0 (Swepub:lu)su7040ul
7001 a Stammet, Pascalu National Fire and Rescue Corps4 aut
7001 a Hirsch, Karenu Stanford University4 aut
7001 a Forsberg, Suneu Karolinska Institutet,Karolinska Institute,Norrtälje Hospital4 aut
7001 a Dupont, Allisonu Heart Center of Northeast Georgia Medical Center4 aut
7001 a Friberg, Hansu Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)efor-hfr
7001 a McPherson, John A.u Vanderbilt University4 aut
7001 a Søreide, Eldaru University of Bergen,Stavanger University Hospital4 aut
7001 a Dankiewicz, Josefu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-jfd
7001 a Cronberg, Tobiasu Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)efor-tcr
7001 a Nielsen, Niklasu Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups,Helsingborg Hospital4 aut0 (Swepub:lu)med-nni
7102 a Anestesiologi och intensivvårdb Sektion II4 org
7730 t Scandinavian Journal of Trauma, Resuscitation and Emergency Medicined : Springer Science and Business Media LLCg 28:1, s. 67-67q 28:1<67-67x 1757-7241
8564 u http://dx.doi.org/10.1186/s13049-020-00760-7x freey FULLTEXT
8564 u https://sjtrem.biomedcentral.com/track/pdf/10.1186/s13049-020-00760-7
8564 8u https://lup.lub.lu.se/record/6dcd8c5d-9ec0-4fbf-bf85-67f2ead85c45
8564 8u https://doi.org/10.1186/s13049-020-00760-7
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:144269816

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