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Sökning: WFRF:(Hellman Mats) > (2020-2024) > Presence of hyaluro...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004475naa a2200541 4500
001oai:DiVA.org:oru-86047
003SwePub
008200928s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-175504
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-860472 URI
0247 a https://doi.org/10.1074/jbc.AC120.0159672 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1755042 URI
040 a (SwePub)orud (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hellman, Urban,d 1966-u Umeå universitet,Kardiologi4 aut0 (Swepub:umu)urhe0001
2451 0a Presence of hyaluronan in lung alveoli in severe Covid-19 :b an opening for new treatment options?
264 1b American Society for Biochemistry and Molecular Biology,c 2020
338 a print2 rdacarrier
520 a Severe corona virus disease 2019 (Covid-19) is characterized by inflammation of the lungs with increasing respiratory impairment. In fatal Covid-19, lungs at autopsy have been filled with a clear liquid jelly. However, the nature of this finding has not yet been determined.The aim of the study was to demonstrate if the lungs of fatal Covid-19 contain hyaluronan as it is associated with inflammation and acute respiratory distress syndrome (ARDS) and may have the appearance of liquid jelly.Lung tissue obtained at autopsy from three deceased Covid-19 patients was processed for hyaluronan histochemistry using a direct staining method and compared with staining in normal lung tissue.Stainings confirmed that hyaluronan is obstructing alveoli with presence in exudate and plugs, as well as in thickened perialveolar interstitium. In contrast, normal lungs only showed hyaluronan in intact alveolar walls and perivascular tissue. This is the first study to confirm prominent hyaluronan exudates in the alveolar spaces of Covid-19 lungs, supporting the notion that the macromolecule is involved in ARDS caused by SARS-CoV-2. The present finding may open up for new treatment options in severe Covid-19, aiming at reducing the presence and production of hyaluronan in the lungs.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a COVID-19
653 a autopsy
653 a coronavirus
653 a extracellular matrix
653 a glycosaminoglycan
653 a hyaluronan
653 a lung
653 a virus
7001 a Karlsson, Mats G.,d 1960-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine4 aut0 (Swepub:oru)mskn
7001 a Engström-Laurent, Annau Umeå universitet,Avdelningen för medicin4 aut0 (Swepub:umu)anen0001
7001 a Cajander, Sara,d 1980-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious diseases4 aut0 (Swepub:oru)scr
7001 a Dorofte, Luiza,d 1982-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine4 aut0 (Swepub:oru)lde
7001 a Ahlm, Clas,d 1956-u Umeå universitet,Institutionen för klinisk mikrobiologi,Clas Ahlm4 aut0 (Swepub:umu)clah0001
7001 a Laurent, Claudeu Umeå universitet,Öron- näs- och halssjukdomar4 aut0 (Swepub:umu)clla0008
7001 a Blomberg, Anders,d 1961-u Umeå universitet,Lungmedicin4 aut0 (Swepub:umu)anbl0001
7102 a Umeå universitetb Kardiologi4 org
7730 t Journal of Biological Chemistryd : American Society for Biochemistry and Molecular Biologyg 295:45, s. 15418-15422q 295:45<15418-15422x 0021-9258x 1083-351X
8564 u https://doi.org/10.1074/jbc.AC120.015967y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1472052/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-86047
8564 8u https://doi.org/10.1074/jbc.AC120.015967
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175504

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