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The expression of a...
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Lindvall, Björn,1952-Linköpings universitet,Neurologi,Hälsouniversitetet
(author)
The expression of adhesion molecules in muscle biopsies : the LFA-1/VLA-4 ratio in polymyositis
- Article/chapterEnglish2003
Publisher, publication year, extent ...
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2003-02-12
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Hindawi Limited,2003
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-26433
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-26433URI
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https://doi.org/10.1034/j.1600-0404.2003.02062.xDOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Objectives– The expression of three pairs of adhesion receptors and ligands was examined in 22 consecutive muscle biopsies showing morphological signs of inflammation.Material and methods– The following groups were studied: patients with polymyositis (PM) (n=7), patients with myositis that did not fulfil criteria for PM, i.e. suspected PM (n=5), patients with other diseases, with no clinical signs of inflammatory myopathy (n=6), and a small group of non-PM inflammatory myopathies (n=4). The endothelial expression of ICAM-1, VCAM-1 and E-selectin was evaluated, as was the cellular expression of LFA-1, VLA-4 and SLex. In addition, the expression of MHC class I and II was studied.Results– The ratio between the number of cells expressing LFA-1 and VLA-4 showed significant differences between the groups, with the lowest values in PM.Conclusion– The LFA-1/VLA-4 ratio should be suitable for diagnostic purposes. Our findings also indicate that the VLA-4/VCAM-1 system is important for chronic T cell inflammation in muscle, in line with findings in other “hidden” organs like joints and the central nervous system.
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Dahlbom, K.Department of Neurology, County Hospital in Örebro, Sweden
(author)
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Henriksson, Karl-Gösta,1928-Linköpings universitet,Neurologi,Hälsouniversitetet(Swepub:liu)karhe89
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Srinivas, U.Linköpings universitet,Klinisk kemi,Hälsouniversitetet
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Ernerudh, Jan,1952-Linköpings universitet,Neurologi,Klinisk kemi,Hälsouniversitetet(Swepub:liu)janer15
(author)
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Linköpings universitetNeurologi
(creator_code:org_t)
Related titles
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In:Acta Neurologica Scandinavica: Hindawi Limited107:2, s. 134-1410001-63141600-0404
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