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  • Brehony, CarinaDept Zool, Univ Oxford, Oxford, England. (författare)

Implications of Differential Age Distribution of Disease-Associated Meningococcal Lineages for Vaccine Development

  • Artikel/kapitelEngelska2014

Förlag, utgivningsår, omfång ...

  • American Society for Microbiology,2014
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-56337
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56337URI
  • https://doi.org/10.1128/CVI.00133-14DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Wellcome TrustEuropean Union 
  • New vaccines targeting meningococci expressing serogroup B polysaccharide have been developed, with some being licensed in Europe. Coverage depends on the distribution of disease-associated genotypes, which may vary by age. It is well established that a small number of hyperinvasive lineages account for most disease, and these lineages are associated with particular antigens, including vaccine candidates. A collection of 4,048 representative meningococcal disease isolates from 18 European countries, collected over a 3-year period, were characterized by multilocus sequence typing (MLST). Age data were available for 3,147 isolates. The proportions of hyperinvasive lineages, identified as particular clonal complexes (ccs) by MLST, differed among age groups. Subjects <1 year of age experienced lower risk of sequence type 11 (ST-11) cc, ST-32 cc, and ST-269 cc disease and higher risk of disease due to unassigned STs, 1- to 4-year-olds experienced lower risk of ST-11 cc and ST-32 cc disease, 5- to 14-year-olds were less likely to experience ST-11 cc and ST-269 cc disease, and >= 25-year-olds were more likely to experience disease due to less common ccs and unassigned STs. Younger and older subjects were vulnerable to a more diverse set of genotypes, indicating the more clonal nature of genotypes affecting adolescents and young adults. Knowledge of temporal and spatial diversity and the dynamics of meningococcal populations is essential for disease control by vaccines, as coverage is lineage specific. The nonrandom age distribution of hyperinvasive lineages has consequences for the design and implementation of vaccines, as different variants, or perhaps targets, may be required for different age groups.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Trotter, Caroline L.Dept Vet Med, Univ Cambridge, Cambridge, England (författare)
  • Ramsay, Mary E.Publ Hlth England, London, England (författare)
  • Chandra, ManosreePubl Hlth England, London, England (författare)
  • Jolley, Keith A.Dept Zool, Univ Oxford, Oxford, England (författare)
  • van der Ende, ArieDept Med Microbiol, Netherlands Reference Lab Bacterial Meningitis, Acad Med Ctr, Univ Amsterdam, Amsterdam, Netherlands (författare)
  • Carion, FrancoiseMeningococcal Reference Lab, Sci Inst Publ Hlth, Brussels, Belgium (författare)
  • Berthelsen, LeneNeisseria & Streptococcus Reference Lab, Statens Serum Inst, Copenhagen, Denmark (författare)
  • Hoffmann, SteenNeisseria & Streptococcus Reference Lab, Statens Serum Inst, Copenhagen, Denmark (författare)
  • Hardardottir, HjordisDept Microbiol, Landspitali Univ Hosp, Reykjavik, Iceland (författare)
  • Vazquez, Julio A.Meningococcal Reference Lab, Madrid, Spain (författare)
  • Murphy, KarenIrish Meningococcal & Meningitis Reference Lab, Dublin, Ireland (författare)
  • Toropainen, MaijaNatl Inst Hlth & Welf, Helsinki, Finland (författare)
  • Canica, ManuelaDept Infect Dis, Lab Antimicrobial Resistance, Natl Inst Hlth Dr Ricardo Jorge, Lisbon, Portugal (författare)
  • Ferreira, EugeniaDept Infect Dis, Lab Antimicrobial Resistance, Natl Inst Hlth Dr Ricardo Jorge, Lisbon, Portugal (författare)
  • Diggle, MathewScottish Haemophilus Legionella Meningococcus & P, Glasgow, UK (författare)
  • Edwards, Giles F.Scottish Haemophilus Legionella Meningococcus & P, Glasgow, UK (författare)
  • Taha, Muhamed-KheirInst Pasteur, Natl Reference Ctr Meningococci, Institut Pasteur, Paris, France (författare)
  • Stefanelli, PaolaDept Infect Parasit & Immune Mediated Dis, Ist Super Sanita, Rome, Italy (författare)
  • Kriz, PaulaNatl Reference Lab Meningococcal Infect, Natl Inst Publ Hlth, Prague, Czech Republic (författare)
  • Gray, Steve J.Meningococcal Reference Unit, Manchester Royal Infirm, Manchester, England (författare)
  • Fox, Andrew J.Meningococcal Reference Unit, Manchester Royal Infirm, Manchester, England (författare)
  • Jacobsson, Susanne,1974-Region Örebro län,National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden(Swepub:oru)sajn (författare)
  • Claus, HeikeInst Hyg & Mikrobiol, Wurzburg, Germany (författare)
  • Vogel, UlrichInst Hyg & Mikrobiol, Wurzburg, Germany (författare)
  • Tzanakaki, GeorginaNatl Meningococcal Reference Lab, Natl Sch Publ Hlth, Athens, Greece (författare)
  • Heuberger, SigridNatl Reference Ctr Meningococci, Inst Med Microbiol & Hyg, Graz, Austria (författare)
  • Caugant, Dominique A.Dept Bacteriol & Immunol, Norwegian Inst Publ Hlth, Oslo, Norway (författare)
  • Frosch, MatthiasInst Hyg & Mikrobiol, Wurzburg, Germany (författare)
  • Maiden, Martin C. J.Dept Zool, Univ Oxford, Oxford, England (författare)
  • Dept Zool, Univ Oxford, Oxford, England.Dept Vet Med, Univ Cambridge, Cambridge, England (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical and Vaccine Immunology: American Society for Microbiology21:6, s. 847-8531556-68111556-679X

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