Search: WFRF:(Holly Elizabeth A.)
> (2020-2023) >
Meta-Analyses of Ge...
Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression
-
Guintivano, Jerry (author)
-
Byrne, Enda M (author)
-
Kiewa, Jacqueline (author)
-
show more...
-
- Yao, Shuyang (author)
- Karolinska Institutet
-
Bauer, Anna E (author)
-
Aberg, Karolina A (author)
-
Adams, Mark J (author)
-
Campbell, Archie (author)
-
Campbell, Megan L (author)
-
Choi, Karmel W (author)
-
Corfield, Elizabeth C (author)
-
Havdahl, Alexandra (author)
-
Hucks, Donald (author)
-
Koen, Nastassja (author)
-
- Lu, Yi (author)
- Karolinska Institutet
-
Mægbæk, Merete L (author)
-
Mullaert, Jimmy (author)
-
Peterson, Roseann E (author)
-
Raffield, Laura M (author)
-
Sallis, Hannah M (author)
-
Sealock, Julia M (author)
-
Walker, Alicia (author)
-
Watson, Hunna J (author)
-
Xiong, Ying (author)
-
Yang, Jessica M K (author)
-
Anney, Richard J L (author)
-
Gordon-Smith, Katherine (author)
-
Hubbard, Leon (author)
-
Jones, Lisa A (author)
-
Mihaescu, Raluca (author)
-
Nyegaard, Mette (author)
-
Pardiñas, Antonio F (author)
-
Perry, Amy (author)
-
Saquib, Nazmus (author)
-
Shadyab, Aladdin H (author)
-
Viktorin, Alexander (author)
-
Andreassen, Ole A (author)
-
Bigdeli, Tim B (author)
-
Davis, Lea K (author)
-
Dennis, Cindy-Lee (author)
-
Di Florio, Arianna (author)
-
Dubertret, Caroline (author)
-
Feng, Yen-Chen A (author)
-
Frey, Benicio N (author)
-
Grigoriadis, Sophie (author)
-
Gloaguen, Emilie (author)
-
Jones, Ian (author)
-
Kennedy, James L (author)
-
Krohn, Holly (author)
-
- Kunovac Kallak, Theodora, 1985- (author)
- Uppsala universitet,Reproduktiv hälsa
-
Li, Yun (author)
-
Martin, Nicholas G (author)
-
McIntosh, Andrew M (author)
-
Milgrom, Jeannette (author)
-
Munk-Olsen, Trine (author)
-
Oberlander, Tim (author)
-
Olsen, Catherine M (author)
-
Ramoz, Nicolas (author)
-
Reichborn-Kjennerud, Ted (author)
-
Robertson Blackmore, Emma (author)
-
Rubinow, David (author)
-
- Skalkidou, Alkistis, 1977- (author)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning
-
Smoller, Jordan W (author)
-
Stein, Dan J (author)
-
Stowe, Zachary N (author)
-
Taylor, Valerie (author)
-
Tebeka, Sarah (author)
-
Tesli, Martin (author)
-
Van Lieshout, Ryan J (author)
-
van den Oord, Edwin J C G (author)
-
Vigod, Simone N (author)
-
Werge, Thomas (author)
-
Westlye, Lars T (author)
-
Whiteman, David C (author)
-
Zar, Heather J (author)
-
Wray, Naomi (author)
-
Meltzer-Brody, Samantha (author)
-
Sullivan, Patrick (author)
-
show less...
-
(creator_code:org_t)
- American Psychiatric Association Publishing, 2023
- 2023
- English.
-
In: American Journal of Psychiatry. - : American Psychiatric Association Publishing. - 0002-953X .- 1535-7228. ; 180:12, s. 884-895
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
http://kipublication...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- OBJECTIVE: Postpartum depression (PPD) is a common subtype of major depressive disorder (MDD) that is more heritable, yet is understudied in psychiatric genetics. The authors conducted meta-analyses of genome-wide association studies (GWASs) to investigate the genetic architecture of PPD.METHOD: Meta-analyses were conducted on 18 cohorts of European ancestry (17,339 PPD cases and 53,426 controls), one cohort of East Asian ancestry (975 cases and 3,780 controls), and one cohort of African ancestry (456 cases and 1,255 controls), totaling 18,770 PPD cases and 58,461 controls. Post-GWAS analyses included 1) single-nucleotide polymorphism (SNP)-based heritability ([Formula: see text]), 2) genetic correlations between PPD and other phenotypes, and 3) enrichment of the PPD GWAS findings in 27 human tissues and 265 cell types from the mouse central and peripheral nervous system.RESULTS: No SNP achieved genome-wide significance in the European or the trans-ancestry meta-analyses. The [Formula: see text] of PPD was 0.14 (SE=0.02). Significant genetic correlations were estimated for PPD with MDD, bipolar disorder, anxiety disorders, posttraumatic stress disorder, insomnia, age at menarche, and polycystic ovary syndrome. Cell-type enrichment analyses implicate inhibitory neurons in the thalamus and cholinergic neurons within septal nuclei of the hypothalamus, a pattern that differs from MDD.CONCLUSIONS: While more samples are needed to reach genome-wide levels of significance, the results presented confirm PPD as a polygenic and heritable phenotype. There is also evidence that despite a high correlation with MDD, PPD may have unique genetic components. Cell enrichment results suggest GABAergic neurons, which converge on a common mechanism with the only medication approved by the U.S. Food and Drug Administration for PPD (brexanolone).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Genetics/Genomics
- Mood Disorders-Postpartum
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Guintivano, Jerr ...
-
Byrne, Enda M
-
Kiewa, Jacquelin ...
-
Yao, Shuyang
-
Bauer, Anna E
-
Aberg, Karolina ...
-
show more...
-
Adams, Mark J
-
Campbell, Archie
-
Campbell, Megan ...
-
Choi, Karmel W
-
Corfield, Elizab ...
-
Havdahl, Alexand ...
-
Hucks, Donald
-
Koen, Nastassja
-
Lu, Yi
-
Mægbæk, Merete L
-
Mullaert, Jimmy
-
Peterson, Rosean ...
-
Raffield, Laura ...
-
Sallis, Hannah M
-
Sealock, Julia M
-
Walker, Alicia
-
Watson, Hunna J
-
Xiong, Ying
-
Yang, Jessica M ...
-
Anney, Richard J ...
-
Gordon-Smith, Ka ...
-
Hubbard, Leon
-
Jones, Lisa A
-
Mihaescu, Raluca
-
Nyegaard, Mette
-
Pardiñas, Antoni ...
-
Perry, Amy
-
Saquib, Nazmus
-
Shadyab, Aladdin ...
-
Viktorin, Alexan ...
-
Andreassen, Ole ...
-
Bigdeli, Tim B
-
Davis, Lea K
-
Dennis, Cindy-Le ...
-
Di Florio, Arian ...
-
Dubertret, Carol ...
-
Feng, Yen-Chen A
-
Frey, Benicio N
-
Grigoriadis, Sop ...
-
Gloaguen, Emilie
-
Jones, Ian
-
Kennedy, James L
-
Krohn, Holly
-
Kunovac Kallak, ...
-
Li, Yun
-
Martin, Nicholas ...
-
McIntosh, Andrew ...
-
Milgrom, Jeannet ...
-
Munk-Olsen, Trin ...
-
Oberlander, Tim
-
Olsen, Catherine ...
-
Ramoz, Nicolas
-
Reichborn-Kjenne ...
-
Robertson Blackm ...
-
Rubinow, David
-
Skalkidou, Alkis ...
-
Smoller, Jordan ...
-
Stein, Dan J
-
Stowe, Zachary N
-
Taylor, Valerie
-
Tebeka, Sarah
-
Tesli, Martin
-
Van Lieshout, Ry ...
-
van den Oord, Ed ...
-
Vigod, Simone N
-
Werge, Thomas
-
Westlye, Lars T
-
Whiteman, David ...
-
Zar, Heather J
-
Wray, Naomi
-
Meltzer-Brody, S ...
-
Sullivan, Patric ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Obstetrics Gynae ...
- Articles in the publication
-
American Journal ...
- By the university
-
Uppsala University
-
Karolinska Institutet