WFRF:(Hortobagyi T)
Search: WFRF:(Hortobagyi T) > (2015-2019) > Synaptic proteins p...
- 3 of 18
- Previous record
- Next record
- To hitlist
Synaptic proteins predict cognitive decline in Alzheimer's disease andLewy body dementia
-
- Bereczki, E. (author)
- Karolinska Institutet
- Francis, P. T. (author)
- Howlett, D. (author)
- show more...
- Hortobágyi, T. (author)
- Attems, J. (author)
- Ballard, C. (author)
- show less...
- (creator_code:org_t)
- 2016-05-22
- 2016
- English.
- In: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 12:11, s. 1149-1158
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Introduction Our objective was to compare the levels of three synaptic proteins involved in different steps of the synaptic transmission: Rab3A, SNAP25, and neurogranin, in three common forms of dementia: Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease dementia. Methods A total of 129 postmortem human brain samples were analyzed in brain regional specific manner exploring their associations with morphologic changes and cognitive decline. Results We have observed robust changes reflecting synaptic dysfunction in all studied dementia groups. There were significant associations between the rate of cognitive decline and decreased levels of Rab3 in DLB in the inferior parietal lobe and SNAP25 in AD in the prefrontal cortex. Of particular note, synaptic proteins significantly discriminated between dementia cases and controls with over 90% sensitivity and specificity. Discussion Our findings suggest that the proposition that synaptic markers can predict cognitive decline in AD, should be extended to Lewy body diseases. © 2016 The Alzheimer's Association
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- Cognitive impairment
- Dementia with Lewy bodies
- Neurogranin
- Parkinson's disease with dementia
- Rab3A
- SNAP25
- Synaptic dysfunction
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Alzheimer's & Dementia (Search for host publication in LIBRIS)
To the university's database
- 3 of 18
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Bereczki, E.
- Francis, P. T.
- Howlett, D.
- Pereira, J. B.
- Höglund, Kina, 1 ...
- Bogstedt, A.
- show more...
- Cedazo-Minguez, ...
- Baek, J. H.
- Hortobágyi, T.
- Attems, J.
- Ballard, C.
- Aarsland, D.
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
- Articles in the publication
- Alzheimer's & De ...
- By the university
- University of Gothenburg
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
