WFRF:(Hudson TJ)
Sökning: WFRF:(Hudson TJ) > (2000-2004) > Association testing...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04571naa a2200469 4500 | |
| 001 | oai:lup.lub.lu.se:9239dd3e-cdba-4b56-82df-97416871583d | |
| 003 | SwePub | |
| 008 | 160401s2004 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/2598962 URI |
| 024 | 7 | a https://doi.org/10.2337/diabetes.53.12.33132 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Florez, JC4 aut |
| 245 | 1 0 | a Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes |
| 264 | 1 | b American Diabetes Association,c 2004 |
| 520 | a The insulin receptor substrate (IRS)-1 is an important component of the insulin signal transduction cascade. Several reports suggest that a Gly-->Arg change in codon 972 is associated with type 2 diabetes and related traits, and a recent meta-analysis reported a modest but nominally significant association with type 2 diabetes (odds ratio [OR] 1.25 in favor of carriers of the Arg allele [95% CI 1.05-1.48). To test the reproducibility of the model in a recent meta-analysis, we examined genotype-phenotype correlation in three large Caucasian samples (not previously reported for this variant) totaling 9,000 individuals (estimated to have >95% power to obtain a P<0.05 for the OR of 1.25 estimated in the meta-analysis). In our combined sample, comprising 4,279 case and 3,532 control subjects, as well as 1,189 siblings discordant for type 2 diabetes, G972R was not associated with type 2 diabetes (OR 0.96 [0.84-1.10], P = 0.60). Genotype at G972R had no significant effect on various measures of insulin secretion or insulin resistance in a set of Scandinavian samples in whom we had detailed phenotypic data. In contrast, the well-documented associations of peroxisome proliferator-activated receptor gamma P12A and Kir6.2 E23K with type 2 diabetes are both robustly observed in these 9,000 subjects, including an additional (previously unpublished) confirmation of Kir6.2 E23K and type 2 diabetes in the Polish and North American samples (combined OR 1.15 [1.05-1.261, P = 0.001). Despite genotyping 9,000 people and >95% power to reproduce the estimated OR from the recent meta-analysis, we were unable to replicate the association of the IRS-1 G972R polymorphism with type 2 diabetes. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 700 | 1 | a Sjögren, Marketau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-msj |
| 700 | 1 | a Burtt, N4 aut |
| 700 | 1 | a Orho-Melander, Marjuu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor |
| 700 | 1 | a Schayer, S4 aut |
| 700 | 1 | a Sun, M4 aut |
| 700 | 1 | a Almgren, Peteru Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-pal |
| 700 | 1 | a Lindblad, Ulfu Lund University,Lunds universitet,Samhällsmedicin,Forskargrupper vid Lunds universitet,Community Medicine,Lund University Research Groups4 aut0 (Swepub:lu)smi-uli |
| 700 | 1 | a Tuomi, T4 aut |
| 700 | 1 | a Gaudet, D4 aut |
| 700 | 1 | a Hudson, TJ4 aut |
| 700 | 1 | a Daly, MJ4 aut |
| 700 | 1 | a Ardlie, KG4 aut |
| 700 | 1 | a Hirschhorn, JN4 aut |
| 700 | 1 | a Altshuler, D4 aut |
| 700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
| 710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Diabetesd : American Diabetes Associationg 53:12, s. 3313-3318q 53:12<3313-3318x 1939-327Xx 0012-1797 |
| 856 | 4 | u http://dx.doi.org/10.2337/diabetes.53.12.3313x freey FULLTEXT |
| 856 | 4 | u http://diabetes.diabetesjournals.org/content/53/12/3313.full.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/259896 |
| 856 | 4 8 | u https://doi.org/10.2337/diabetes.53.12.3313 |
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