SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Huisman Marc C)
 

Sökning: WFRF:(Huisman Marc C) > Noninvasive Quantif...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004899naa a2200469 4500
001oai:DiVA.org:uu-304175
003SwePub
008161003s2016 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3041752 URI
0247 a https://doi.org/10.2967/jnumed.115.1674372 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Harms, Hendrik J.u Vrije Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, POB 7057, NL-1007 MB Amsterdam, Netherlands.4 aut
2451 0a Noninvasive Quantification of Myocardial C-11-Meta-Hydroxyephedrine Kinetics
264 c 2016-05-26
264 1b Society of Nuclear Medicine,c 2016
338 a print2 rdacarrier
520 a C-11-meta-hydroxyephedrine (C-11-HED) kinetics in the myocardium can be quantified using a single-tissue-compartment model together with a metabolite-corrected arterial blood sampler input function (BSIF). The need for arterial blood sampling, however, limits clinical applicability. The purpose of this study was to investigate the feasibility of replacing arterial sampling with imaging-derived input function (IDIF) and venous blood samples. Methods: Twenty patients underwent 60-min dynamic C-11-HED PET/CT scans with online arterial blood sampling. Thirteen of these patients also underwent venous blood sampling. Data were reconstructed using both 3 dimensional row-action maximum-likelihood algorithm (3DR) and a time-of-flight (TF) list-mode reconstruction algorithm. For each reconstruction, IDIF results were compared with BSIF results. In addition, IDIF results obtained with venous blood samples and with a transformed venous-to-arterial metabolite correction were compared with results obtained with arterial metabolite corrections. Results: Correlations between IDIF- and BSIF-derived K-1 and V-T were high (r(2) > =0.89 for 3DR and TF). Slopes of the linear fits were significantly different from 1 for K-1, for both 3DR (slope = 0.94) and TF (slope = 1.06). For V-T, the slope of the linear fit was different from 1 for TF (slope = 0.93) but not for 3DR (slope = 0.98). Use of venous blood data introduced a large bias in V-T (r(2) = 0.96, slope = 0.84) and a small bias in K-1 (r(2) = 0.99, slope = 0.98). Use of a second-order polynomial venous-to-arterial transformation was robust and greatly reduced bias in V-T (r(2) = 0.97, slope = 0.99) with no effect on K-1. Conclusion: IDIF yielded precise results for both 3DR and TF. Venous blood samples can be used for absolute quantification of C-11-HED studies, provided a venous-to-arterial transformation is applied. A venous-to-arterial transformation enables noninvasive, absolute quantification of C-11-HED studies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
653 a sympathetic innervation
653 a C-11-HED
653 a absolute quantification
653 a image derived input function
653 a blood samples
7001 a Huisman, Marc C.u Vrije Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, POB 7057, NL-1007 MB Amsterdam, Netherlands.4 aut
7001 a Rijnierse, Mischa T.u Vrije Univ Amsterdam, Med Ctr, Dept Cardiol, Amsterdam, Netherlands.4 aut
7001 a Greuter, Henriu Vrije Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, POB 7057, NL-1007 MB Amsterdam, Netherlands.4 aut
7001 a Hsieh, Yu-Lungu Philips Healthcare, Cleveland, OH USA.4 aut
7001 a de Haan, Stefanu Vrije Univ Amsterdam, Med Ctr, Dept Cardiol, Amsterdam, Netherlands.4 aut
7001 a Schuit, Robert C.u Vrije Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, POB 7057, NL-1007 MB Amsterdam, Netherlands.4 aut
7001 a Knaapen, Paulu Vrije Univ Amsterdam, Med Ctr, Dept Cardiol, Amsterdam, Netherlands.4 aut
7001 a Lubberink, Marku Uppsala universitet,Radiologi,Vrije Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, POB 7057, NL-1007 MB Amsterdam, Netherlands.4 aut0 (Swepub:uu)marklubb
7001 a Lammertsma, Adriaan A.u Vrije Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, POB 7057, NL-1007 MB Amsterdam, Netherlands.4 aut
7102 a Vrije Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, POB 7057, NL-1007 MB Amsterdam, Netherlands.b Vrije Univ Amsterdam, Med Ctr, Dept Cardiol, Amsterdam, Netherlands.4 org
7730 t Journal of Nuclear Medicined : Society of Nuclear Medicineg 57:9, s. 1376-1381q 57:9<1376-1381x 0161-5505x 1535-5667x 2159-662X
8564 u http://jnm.snmjournals.org/content/57/9/1376.full.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-304175
8564 8u https://doi.org/10.2967/jnumed.115.167437

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy