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Docetaxel plus pred...
Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
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Tannock, Ian F. (author)
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de Wit, Ronald (author)
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Berry, William R. (author)
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Horti, Jozsef (author)
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Pluzanska, Anna (author)
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Chi, Kim N. (author)
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Oudard, Stephane (author)
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Théodore, Christine (author)
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James, Nicholas D. (author)
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- Turesson, Ingela (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Radiobiol-IT
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Rosenthal, Mark A. (author)
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Eisenberger, Mario A. (author)
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(creator_code:org_t)
- 2004
- 2004
- English.
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In: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 351:15, s. 1502-12
- Related links:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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Abstract
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- BACKGROUND: Mitoxantrone plus prednisone reduces pain and improves the quality of life in men with advanced, hormone-refractory prostate cancer, but it does not improve survival. We compared such treatment with docetaxel plus prednisone in men with this disease. METHODS: From March 2000 through June 2002, 1006 men with metastatic hormone-refractory prostate cancer received 5 mg of prednisone twice daily and were randomly assigned to receive 12 mg of mitoxantrone per square meter of body-surface area every three weeks, 75 mg of docetaxel per square meter every three weeks, or 30 mg of docetaxel per square meter weekly for five of every six weeks. The primary end point was overall survival. Secondary end points were pain, prostate-specific antigen (PSA) levels, and the quality of life. All statistical comparisons were against mitoxantrone. RESULTS: As compared with the men in the mitoxantrone group, men in the group given docetaxel every three weeks had a hazard ratio for death of 0.76 (95 percent confidence interval, 0.62 to 0.94; P=0.009 by the stratified log-rank test) and those given weekly docetaxel had a hazard ratio for death of 0.91 (95 percent confidence interval, 0.75 to 1.11; P=0.36). The median survival was 16.5 months in the mitoxantrone group, 18.9 months in the group given docetaxel every 3 weeks, and 17.4 months in the group given weekly docetaxel. Among these three groups, 32 percent, 45 percent, and 48 percent of men, respectively, had at least a 50 percent decrease in the serum PSA level (P<0.001 for both comparisons with mitoxantrone); 22 percent, 35 percent (P=0.01), and 31 percent (P=0.08) had predefined reductions in pain; and 13 percent, 22 percent (P=0.009), and 23 percent (P=0.005) had improvements in the quality of life. Adverse events were also more common in the groups that received docetaxel. CONCLUSIONS: When given with prednisone, treatment with docetaxel every three weeks led to superior survival and improved rates of response in terms of pain, serum PSA level, and quality of life, as compared with mitoxantrone plus prednisone.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Adenocarcinoma/*drug therapy/mortality
- Aged
- Aged; 80 and over
- Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use
- Comparative Study
- Drug Resistance; Neoplasm
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Mitoxantrone/*administration & dosage/adverse effects
- Prednisone/*administration & dosage
- Prostatic Neoplasms/*drug therapy/mortality
- Quality of Life
- Research Support; Non-U.S. Gov't
- Survival Analysis
- Taxoids/*administration & dosage/adverse effects
- Oncology
- Onkologi
Publication and Content Type
- vet (subject category)
- art (subject category)
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- By the author/editor
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Tannock, Ian F.
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de Wit, Ronald
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Berry, William R ...
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Horti, Jozsef
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Pluzanska, Anna
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Chi, Kim N.
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show more...
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Oudard, Stephane
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Théodore, Christ ...
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James, Nicholas ...
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Turesson, Ingela
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Rosenthal, Mark ...
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Eisenberger, Mar ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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New England Jour ...
- By the university
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Uppsala University