WFRF:(Janoueix Lerosey I.)
Sökning: WFRF:(Janoueix Lerosey I.) > The constitutive ac...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03825naa a2200505 4500 | |
| 001 | oai:DiVA.org:umu-43275 | |
| 003 | SwePub | |
| 008 | 110426s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-432752 URI |
| 024 | 7 | a https://doi.org/10.1038/onc.2010.5952 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Mazot, P4 aut |
| 245 | 1 0 | a The constitutive activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking |
| 264 | c 2011-01-17 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2011 |
| 338 | a print2 rdacarrier | |
| 520 | a Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK), which is transiently expressed during development of the central and peripheral nervous system. ALK has been recently identified as a major neuroblastoma predisposition gene and activating mutations have also been identified in a subset of sporadic neuroblastoma tumors. Two hot spots of ALK mutations have been observed at positions F1174 and R1275. Here, we studied stably transfected cell lines expressing wild-type or F1174L- or R1275Q-mutated ALK in parallel with a neuroblastoma cell line (CLB-GE) in which the allele mutated at position F1174 is amplified. We observed that the mutated ALK variants were essentially intracellular and were largely retained in the reticulum/Golgi compartments. This localization was corroborated by a defect of N-linked glycosylation. Although the mutated receptors exhibited a constitutive activation, the minor pool of receptor addressed to the plasma membrane was much more tyrosine phosphorylated than the intracellular pool. The use of antagonist monoclonal antibodies suggested that the constitutive activity of the mutated receptors did not require the dimerization of the receptor, whereas adequate dimerization triggered by agonist monoclonal antibodies increased this activity. Finally, kinase inactivation of the mutated receptors restored maturation and cell-surface localization. Our results show that constitutive activation of ALK results in its impaired maturation and intracellular retention. Furthermore, they provide a rationale for the potential use of kinase inhibitors and antibodies in ALK-dependent tumors.Oncogene advance online publication, 17 January 2011; doi:10.1038/onc.2010.595. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
| 653 | a ALK | |
| 653 | a neuroblastoma | |
| 653 | a phosphorylation | |
| 653 | a ER retention | |
| 653 | a RTK | |
| 653 | a Molecular biology | |
| 653 | a Molekylärbiologi | |
| 700 | 1 | a Cazes, A4 aut |
| 700 | 1 | a Boutterin, M C4 aut |
| 700 | 1 | a Figueiredo, A4 aut |
| 700 | 1 | a Raynal, V4 aut |
| 700 | 1 | a Combaret, V4 aut |
| 700 | 1 | a Hallberg, Bengtu Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Hallberg4 aut0 (Swepub:umu)beha0004 |
| 700 | 1 | a Palmer, Ruth Hu Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)4 aut0 (Swepub:umu)rupa0001 |
| 700 | 1 | a Delattre, O4 aut |
| 700 | 1 | a Janoueix-Lerosey, I4 aut |
| 700 | 1 | a Vigny, M4 aut |
| 710 | 2 | a Umeå universitetb Institutionen för molekylärbiologi (Medicinska fakulteten)4 org |
| 773 | 0 | t Oncogened : Springer Science and Business Media LLCg 30, s. 2017-2025q 30<2017-2025x 0950-9232x 1476-5594 |
| 856 | 4 | u https://www.nature.com/articles/onc2010595.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-43275 |
| 856 | 4 8 | u https://doi.org/10.1038/onc.2010.595 |
Hitta mer i SwePub
- Av författaren/redakt...
- Mazot, P
- Cazes, A
- Boutterin, M C
- Figueiredo, A
- Raynal, V
- Combaret, V
- visa fler...
- Hallberg, Bengt
- Palmer, Ruth H
- Delattre, O
- Janoueix-Lerosey ...
- Vigny, M
- visa färre...
- Om ämnet
-
- NATURVETENSKAP
- NATURVETENSKAP
- och Biologi
- och Biokemi och mole ...
- Artiklar i publikationen
- Oncogene
- Av lärosätet
- Umeå universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
