WFRF:(Jensen Gorm Boje)
Sökning: WFRF:(Jensen Gorm Boje) > Brain structure and...
Brain structure and function as mediators of the effects of amyloid on memory
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- Mattsson, Niklas, 1979 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
- Insel, P. S. (författare)
- Aisen, P. S. (författare)
- visa fler...
- Jagust, W. (författare)
- Mackin, S. (författare)
- Weiner, M. (författare)
- visa färre...
- (creator_code:org_t)
- 2015-02-13
- 2015
- Engelska.
- Ingår i: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 0028-3878 .- 1526-632X. ; 84:11, s. 1136-1144
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Objective:The objective of this study was to test whether effects of -amyloid (A) pathology on episodic memory were mediated by metabolism and gray matter volume in the early stages of Alzheimer disease.Methods:This was a prospective cohort study. We measured baseline A (using florbetapir-PET), brain function (using fluorodeoxyglucose-PET), and brain structure (using MRI). A mediation analysis was performed to test whether statistical effects of A positivity on cross-sectional and longitudinal episodic memory were mediated by hypometabolism or regional gray matter volume in cognitively healthy controls (CN, n = 280) and mild cognitive impairment (MCI, n = 463).Results:Lower memory scores were associated with A positivity (CN, mildly; MCI, strongly), smaller gray matter volumes (CN, few regions, including hippocampus; MCI, widespread), and hypometabolism. Smaller volumes and hypometabolism mediated effects of A in MCI but not in CN. The strongest individual regions mediated up to approximately 25%. A combination of brain structure and function mediated up to approximately 40%. In several regions, gray matter atrophy and hypometabolism predicted episodic memory without being associated (at p < 0.05) with A positivity.Conclusions:Changes in brain structure and function appear to be, in part, downstream events from A pathology, ultimately resulting in episodic memory deficits. However, A pathology is also strongly related to memory deficits through mechanisms that are not quantified by these imaging measurements, and episodic memory decline is partly caused by Alzheimer disease-like brain changes independently of A pathology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- PRECLINICAL ALZHEIMERS-DISEASE
- MILD COGNITIVE IMPAIRMENT
- ELDERLY
- SUBJECTS
- EPISODIC MEMORY
- OLDER-ADULTS
- ATROPHY
- BIOMARKERS
- DECLINE
- DEPOSITION
- PATHOLOGY
- Clinical Neurology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
- Mattsson, Niklas ...
- Insel, P. S.
- Aisen, P. S.
- Jagust, W.
- Mackin, S.
- Weiner, M.
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Cell och molekyl ...
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- Neurology
- Av lärosätet
- Göteborgs universitet
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