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Sökning: onr:"swepub:oai:openarchive.ki.se:10616/45317" > Common genetic vari...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003546naa a2200505 4500
001oai:openarchive.ki.se:10616/45317
003SwePub
008240410s2016 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:134559380
022 a 1949-2553
0247 a 10616/453172 hdl
0247 a http://hdl.handle.net/10616/453172 URI
0247 a https://doi.org/10.18632/oncotarget.115752 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1345593802 URI
040 a (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Adel Fahmideh, Maralu Karolinska Institutet4 aut
2451 0a Common genetic variations in cell cycle and DNA repair pathways associated with pediatric brain tumor susceptibility
264 c 2016-08-24
264 1a Stockholm :b Karolinska Institutet, Institute of Environmental Medicine,c 2016
338 a electronic2 rdacarrier
520 a Knowledge on the role of genetic polymorphisms in the etiology of pediatric brain tumors (PBTs) is limited. Therefore, we investigated the association between single nucleotide polymorphisms (SNPs), identified by candidate gene-association studies on adult brain tumors, and PBT risk. The study is based on the largest series of PBT cases to date. Saliva DNA from 245 cases and 489 controls, aged 7–19 years at diagnosis/reference date, was genotyped for 68 SNPs. Data were analyzed using unconditional logistic regression. The results showed EGFRrs730437 and EGFRrs11506105 may decrease susceptibility to PBTs, whereas ERCC1rs3212986 may increase risk of these tumors. Moreover, stratifid analyses indicated CHAF1Ars243341, CHAF1Ars2992, and XRCC1rs25487 were associated with a decreased risk of astrocytoma subtype. Furthermore, an increased risk of non-astrocytoma subtype associated with EGFRrs9642393, EME1rs12450550, ATMrs170548, and GLTSCRrs1035938 as well as a decreased risk of this subtype associated with XRCC4rs7721416 and XRCC4rs2662242 were detected. This study indicates SNPs in EGFR, ERCC1, CHAF1A, XRCC1, EME1, ATM, GLTSCR1, and XRCC4 may be associated with the risk of PBTs. Therefore, cell cycle and DNA repair pathways variations associated with susceptibility to adult brain tumors also seem to be associated with PBT risk, suggesting pediatric and adult brain tumors might share similar etiological pathways.
7001 a Lavebratt, Catharinau Karolinska Institutet4 aut
7001 a Schüz, Joachim4 aut
7001 a Röösli, Martin4 aut
7001 a Tynes, Tore4 aut
7001 a Grotzer, Michael A4 aut
7001 a Johansen, Christoffer4 aut
7001 a Kuehni, Claudia E4 aut
7001 a Lannering, Birgitta4 aut
7001 a Prochazka, Michaela4 aut
7001 a Schmidt, Lisbeth S4 aut
7001 a Feychting, Mariau Karolinska Institutet4 aut
7102 a Karolinska Institutet
7102 a Karolinska Institutet
7102 a Karolinska Institutet4 org
7730 t Oncotargetd Stockholm : Karolinska Institutet, Institute of Environmental Medicinex 1949-2553
8564 u http://hdl.handle.net/10616/45317x primaryx Object in contextx freey FULLTEXT
8564 u http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=11575&path%5B%5D=36661
8564 8u http://hdl.handle.net/10616/45317
8564 8u https://doi.org/10.18632/oncotarget.11575
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:134559380

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