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C-Peptide replaceme...
C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy
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Ekberg, Karin (author)
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- Brismar, Tom (author)
- Karolinska Institutet
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Johansson, Bo-Lennart (author)
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Lindström, Per (author)
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- Juntti-Berggren, Lisa (author)
- Karolinska Institutet
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Norrby, Anders (author)
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- Berne, Christian (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi, diabetes och metabolism
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- Arnqvist, Hans, 1943- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för medicinsk cellbiologi,Endokrin- och magtarmmedicinska kliniken US
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- Bolinder, Jan (author)
- Karolinska Institutet
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- Wahren, John (author)
- Karolinska Institutet
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(creator_code:org_t)
- American Diabetes Association, 2007
- 2007
- English.
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In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 30:1, s. 71-76
- Related links:
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http://care.diabetes...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
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- OBJECTIVE - C-peptide replacement in animals results in amelioration of diabetes-induced functional and structural abnormalities in peripheral nerves. The present study was undertaken to examine whether C-peptide administration to patients with type 1 diabetes and peripheral neuropathy improves sensory nerve function. RESEARCH DESIGN AND METHODS - This was an exploratory, double-blinded, randomized, and placebo-controlled study with three study groups that was carried out at five centers in Sweden. C-peptide was given as a replacement dose (1.5 mg/day, divided into four subcutaneous doses) or a dose three times higher (4.5 mg/day) during 6 months. Neurological examination and neurophysiological measurements were performed before and after 6 months of treatment with C-peptide or placebo. RESULTS - The age of the 139 patients who completed the protocol was 44.2 ± 0.6 (mean ± SE) years and their duration of diabetes was 30.6 ± 0.8 years. Clinical neurological impairment (NIA) (score >7 points) of the lower extremities was present in 86% of the patients at baseline. Sensory nerve conduction velocity (SCV) was 2.6 ± 0.08 SD below body height-corrected normal values at baseline and improved similarly within the two C-peptide groups (P < 0.007). The number of patients responding with a SCV peak potential improvement >1.0 m/s was greater in C-peptide-treated patients than in those receiving placebo (P < 0.03). In the least severely affected patients (SCV < 2.5 SD below normal at baseline, n = 70) SCV improved by 1.0 m/s (P < 0.014 vs. placebo). NIA score and vibration perception both improved within the C-peptide-treated groups (P < 0.011 and P < 0.002). A1C levels (7.6 ± 0.1% at baseline) decreased slightly but similarly in C-peptide- and placebo-treated patients during the study. CONCLUSIONS - C-peptide treatment for 6 months improves sensory nerve function in early-stage type 1 diabetic neuropathy.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ekberg, Karin
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Brismar, Tom
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Johansson, Bo-Le ...
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Lindström, Per
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Juntti-Berggren, ...
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Norrby, Anders
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show more...
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Berne, Christian
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Arnqvist, Hans, ...
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Bolinder, Jan
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Wahren, John
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show less...
- Articles in the publication
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Diabetes Care
- By the university
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Uppsala University
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Karolinska Institutet
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Linköping University