WFRF:(Kapraali Marjo)
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Clinical application of the multigene analysis test in discriminating between ulcerative colitis and Crohn's disease : a retrospective study
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- Janczewska, Izabella (author)
- Karolinska Institutet
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- Kapraali, Marjo (author)
- Karolinska Institutet
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- Saboonchi, Fredrik (author)
- Karolinska Institutet,Sophiahemmet Högskola,Sophiahemmet University College, Stockholm
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- (creator_code:org_t)
- 2012-01-10
- 2012
- English.
- In: Scandinavian journal of gastroenterology. - : Informa UK Limited. - 1502-7708 .- 0036-5521. ; 47:2, s. 162-9
- Journal article (peer-reviewed)
Abstract
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- Abstract Methods. The newly described - multigene analysis test (DiBiCol) identifying 7 inflammatory bowel disease (IBD)-specific genes in colonic mucosal biopsy differentiating between ulcerative colitis (UC) and Crohn's disease (CD) with active inflammation - is a new addition to existing methods with a higher stated sensitivity and specificity. Method biopsy material from 78 patients with a complicated course diagnosed as most probably UC in 38, CD in 18 and inflammatory bowel disease unclassified (IBDU) in 22 were investigated by DiBiCol. Results. DiBiCol showed a pattern consistent with CD in 13 patients with UC and led to change of diagnosis in 3 patients and a strong suggestion of CD in 8 patients. A total of 2 patients remained as UC. DiBiCol showed a pattern of UC in 4 patients of 18 with CD leading to a changing of diagnosis to UC in 3 patients, but the fourth remained as CD. In 22 patients with IBDU DiBiCol showed a pattern consistent with UC in 7 cases and with CD in 13 cases. A new evaluation 1 year after the DiBiCol allowed the assessment of clinical diagnosis in 10 patients confirmed in 9 of 10 patients by DiBiCol. In patients with acute flare of colitis the clinical diagnosis corresponded in 10 of 12 UC and in 5 of 6 CD cases. Summary. Adopting the DiBiCol test led to a change of the primary diagnosis in a significant number of patients with the initial diagnosis of UC and CD and suggested a clinically probable diagnosis in most of the patients with IBDU and in those with an acute flare of colitis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- DiBiCol
- Inflammatory bowel diseases
- Multigene analysis test
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Marouf, F
- Gorsetman, J
- Risberg, D
- Lissing, M
- Wirström, G
- Sandstedt, B
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