STK4 protein expression pattern follows different trends in endometrioid and serous endometrial adenocarcinoma upon tumor progression

Govorov, IgorDivision of Obstetrics and Gynecology, Department of Women's and Children's Health, Karolinska University Hospital, Solna, Sweden: Karolinska Institutet, 171 77, Stockholm, Sweden (författare)

Funding agency:National Academy of Science of Ukraine 2.2.5.384
In a previous study, we showed that serine/threonine-protein kinase 4 (STK4) is involved in the control on proliferation and migration of endometrial cancer (EC) cells in vitro. In the present paper, we studied STK4 expression in EC tissues from a large cohort of patients to determine whether STK4 can serve as a marker for the aggressiveness and prognosis of EC. Tissue samples from patients with EC were examined for tumor type, grade, and stage. The STK4 protein expression in EC cells was assessed by immunohistochemistry and related to clinicopathological data of patients, such as progression and patient survival rate. The STK4 mRNA levels and its relation to the survival rate were analyzed also in publicly available databases. The STK4 gene expression was low at both, the mRNA and protein levels in EC, especially in serous tumors. Comparison of STK4 expression with the patient survival rate shows that the higher expression is associated with worse prognosis in serous EC, while no such dependence was found in endometrioid EC. Hence, the determination of the SKT4 expression pattern could be used as a putative prognostic marker for serous EC.

Attarha, SanazScience for Life Laboratory, Karolinska Institutet, 171 65, Stockholm, Sweden (författare)
Kovalevska, LarysaR.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine, Kyiv, 03022, Ukraine (författare)
Andersson, EmilDivision of Obstetrics and Gynecology, Department of Women's and Children's Health, Karolinska University Hospital, Solna, Sweden; Karolinska Institutet, 171 77, Stockholm, Sweden (författare)
Kashuba, ElenaKarolinska Institutet (författare)
Mints, Miriam,1958-Örebro universitet,Institutionen för medicinska vetenskaper,Division of Obstetrics and Gynecology, Department of Women's and Children's Health, Karolinska University Hospital, Solna, Karolinska Institutet, 171 77, Stockholm, Sweden(Swepub:oru)mms (författare)
Division of Obstetrics and Gynecology, Department of Women's and Children's Health, Karolinska University Hospital, Solna, Sweden: Karolinska Institutet, 171 77, Stockholm, SwedenScience for Life Laboratory, Karolinska Institutet, 171 65, Stockholm, Sweden (creator_code:org_t)

Av författaren/redakt...: Govorov, Igor; Attarha, Sanaz; Kovalevska, Lary ...; Andersson, Emil; Kashuba, Elena; Mints, Miriam, 1 ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.