Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent

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Fältnamn	Indikatorer	Metadata
000		08287naa a2201129 4500
001		oai:lup.lub.lu.se:aa4c3f3c-9b75-46a3-ad41-76eb1d703038
003		SwePub
008		180215s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/aa4c3f3c-9b75-46a3-ad41-76eb1d7030382 URI
024	7	a https://doi.org/10.1002/mnfr.2017003472 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Smith, Caren E.u Tufts University4 aut
245	1 0	a Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent
264		c 2017-12-11
264	1	b Wiley,c 2018
520		a Scope: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption. Methods and results: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10−7), and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3’ of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10−8) such that each serving of low-fat dairy was associated with 0.225 kg m−2 lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure. Conclusion: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653		a body mass index
653		a CHARGE consortium
653		a dairy intake
653		a genome-wide interaction study
653		a meta-analysis
700	1	a Follis, Jack L.u University of St Thomas, Houston4 aut
700	1	a Dashti, Hassan S.u Broad Institute,Massachusetts General Hospital4 aut
700	1	a Tanaka, Toshikou National Institute on Aging, United States4 aut
700	1	a Graff, Mariaelisau University of North Carolina4 aut
700	1	a Fretts, Amanda M.u University of Washington4 aut
700	1	a Kilpeläinen, Tuomas O.u University of Copenhagen4 aut
700	1	a Wojczynski, Mary K.u Washington University in St. Louis4 aut
700	1	a Richardson, Krisu Tufts University4 aut
700	1	a Nalls, Mike A.u National Institute on Aging, United States,Kelly Services4 aut
700	1	a Schulz, Christina Alexandrau Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)med-csc
700	1	a Liu, Yongmeiu Wake Forest University4 aut
700	1	a Frazier-Wood, Alexis C.u Baylor College of Medicine4 aut
700	1	a van Eekelen, Estheru Leiden University Medical Centre4 aut
700	1	a Wang, Carolu University of Western Australia, Crawley4 aut
700	1	a de Vries, Paul S.u Erasmus University Medical Center,University of Texas4 aut
700	1	a Mikkilä, Verau University of Turku,University of Helsinki4 aut
700	1	a Rohde, Rebeccau University of North Carolina4 aut
700	1	a Psaty, Bruce M.u University of Washington,Group Health Cooperative4 aut
700	1	a Hansen, Torbenu University of Copenhagen4 aut
700	1	a Feitosa, Mary F.u Washington University in St. Louis4 aut
700	1	a Lai, Chao Qiangu Tufts University4 aut
700	1	a Houston, Denise K.u Wake Forest University4 aut
700	1	a Ferruci, Luigiu National Institute on Aging, United States4 aut
700	1	a Ericson, Ulrikau Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)medf-upe
700	1	a Wang, Zheu University of Texas4 aut
700	1	a de Mutsert, Renéeu Leiden University Medical Centre4 aut
700	1	a Oddy, Wendy H.u University of Tasmania4 aut
700	1	a de Jonge, Ester A.L.u Erasmus University Medical Center4 aut
700	1	a Seppälä, Ilkkau University of Tampere4 aut
700	1	a Justice, Anne E.u University of North Carolina4 aut
700	1	a Lemaitre, Rozenn N.u University of Washington4 aut
700	1	a Sørensen, Thorkild I.A.u University of Bristol,Bispebjerg Hospital,University of Copenhagen4 aut
700	1	a Province, Michael A.u Washington University in St. Louis4 aut
700	1	a Parnell, Laurence D.u Tufts University4 aut
700	1	a Garcia, Melissa E.u National Institute on Aging, United States4 aut
700	1	a Bandinelli, Stefaniau Azienda Sanitaria Firenze (ASF)4 aut
700	1	a Orho-Melander, Marjuu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor
700	1	a Rich, Stephen S.u University of Virginia4 aut
700	1	a Rosendaal, Frits R.u Leiden University Medical Centre4 aut
700	1	a Pennell, Craig E.u University of Western Australia, Crawley4 aut
700	1	a Kiefte-de Jong, Jessica C.u Erasmus University Medical Center4 aut
700	1	a Kähönen, Mikau University of Tampere,Tampere University Hospital4 aut
700	1	a Young, Kristin L.u University of North Carolina4 aut
700	1	a Pedersen, Olufu University of Copenhagen4 aut
700	1	a Aslibekyan, Stellau University of Alabama4 aut
700	1	a Rotter, Jerome I.u Harbor–UCLA Medical Center4 aut
700	1	a Mook-Kanamori, Dennis O.u Leiden University Medical Centre4 aut
700	1	a Zillikens, M. Carolau Erasmus University Medical Center4 aut
700	1	a Raitakari, Olli T.u University of Turku4 aut
700	1	a North, Kari E.u University of North Carolina4 aut
700	1	a Overvad, Kimu Aarhus University,Aalborg University Hospital4 aut
700	1	a Arnett, Donna K.u University of Kentucky4 aut
700	1	a Hofman, Albertu Erasmus University Medical Center,Harvard University4 aut
700	1	a Lehtimäki, Terhou University of Tampere4 aut
700	1	a Tjønneland, Anneu Danish Cancer Society4 aut
700	1	a Uitterlinden, André G.u Erasmus University Medical Center4 aut
700	1	a Rivadeneira, Fernandou Netherlands Genomics Initiative,Erasmus University Medical Center4 aut
700	1	a Franco, Oscar H.u Erasmus University Medical Center4 aut
700	1	a German, J. Bruceu University of California, Davis4 aut
700	1	a Siscovick, David S.u New York Academy of Medicine4 aut
700	1	a Cupples, L. Adrienneu Boston University4 aut
700	1	a Ordovás, José M.u Centro Nacional de Investigaciones Cardiovasculares Carlos III,IMDEA Institute,Tufts University4 aut
710	2	a Tufts Universityb University of St Thomas, Houston4 org
773	0	t Molecular Nutrition & Food Researchd : Wileyg 62:3q 62:3x 1613-4125
856	4	u http://dx.doi.org/10.1002/mnfr.201700347y FULLTEXT
856	4	u https://europepmc.org/articles/pmc5803424?pdf=render
856	4 8	u https://lup.lub.lu.se/record/aa4c3f3c-9b75-46a3-ad41-76eb1d703038
856	4 8	u https://doi.org/10.1002/mnfr.201700347

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Av författaren/redakt...: Smith, Caren E.; Follis, Jack L.; Dashti, Hassan S ...; Tanaka, Toshiko; Graff, Mariaelis ...; Fretts, Amanda M ...; visa fler...; Kilpeläinen, Tuo ...; Wojczynski, Mary ...; Richardson, Kris; Nalls, Mike A.; Schulz, Christin ...; Liu, Yongmei; Frazier-Wood, Al ...; van Eekelen, Est ...; Wang, Carol; de Vries, Paul S ...; Mikkilä, Vera; Rohde, Rebecca; Psaty, Bruce M.; Hansen, Torben; Feitosa, Mary F.; Lai, Chao Qiang; Houston, Denise ...; Ferruci, Luigi; Ericson, Ulrika; Wang, Zhe; de Mutsert, René ...; Oddy, Wendy H.; de Jonge, Ester ...; Seppälä, Ilkka; Justice, Anne E.; Lemaitre, Rozenn ...; Sørensen, Thorki ...; Province, Michae ...; Parnell, Laurenc ...; Garcia, Melissa ...; Bandinelli, Stef ...; Orho-Melander, M ...; Rich, Stephen S.; Rosendaal, Frits ...; Pennell, Craig E ...; Kiefte-de Jong, ...; Kähönen, Mika; Young, Kristin L ...; Pedersen, Oluf; Aslibekyan, Stel ...; Rotter, Jerome I ...; Mook-Kanamori, D ...; Zillikens, M. Ca ...; Raitakari, Olli ...; North, Kari E.; Overvad, Kim; Arnett, Donna K.; Hofman, Albert; Lehtimäki, Terho; Tjønneland, Anne; Uitterlinden, An ...; Rivadeneira, Fer ...; Franco, Oscar H.; German, J. Bruce; Siscovick, David ...; Cupples, L. Adri ...; Ordovás, José M.; visa färre...

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