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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003119naa a2200517 4500
001oai:DiVA.org:uu-151506
003SwePub
008110412s2010 | |||||||||||000 ||eng|
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1515062 URI
024a https://doi.org/10.2217/pgs.10.742 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Verhoef, Talitha I4 aut
2451 0a A systematic review of cost-effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives.
264 1b Future Medicine Ltd,c 2010
338 a print2 rdacarrier
520 a Anticoagulant therapy with coumarin derivatives is often sub- or supra-therapeutic, resulting in an increased risk of thromboembolic events or hemorrhage, respectively. Pharmacogenetic-guided dosing has been proposed as an effective way of reducing bleeding rates. Clinical trials to confirm the safety, efficacy and effectiveness of this strategy are ongoing, but in addition, it is also necessary to consider the cost-effectiveness of this strategy. This article describes the findings of a systematic review of published cost-effectiveness analyses of pharmacogenetic-guided dosing of coumarin derivatives. Similarities and differences in the approaches used were examined and the quality of the analyses was assessed. The results of the analyses are not sufficient to determine whether or not pharmacogenetic-guided dosing of coumarins is cost effective. More reliable cost-effectiveness estimates need to become available before it is possible to recommend whether or not this strategy should be applied in clinical practice.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
653 a MEDICINE
653 a MEDICIN
700a Redekop, William K4 aut
700a Darba, Josep4 aut
700a Geitona, Mary4 aut
700a Hughes, Dyfrig A4 aut
700a Siebert, Uwe4 aut
700a de Boer, Anthonius4 aut
700a Maitland-van der Zee, Anke-Hilse4 aut
700a Barallon, Rita4 aut
700a Briz, Montserrat4 aut
700a Daly, Ann4 aut
700a Haschke-Becher, Elisabeth4 aut
700a Kamali, Farhad4 aut
700a Kirchheiner, Julia4 aut
700a Manolopoulos, Vangelis G4 aut
700a Pirmohamed, Munir4 aut
700a Rosendaal, Frits R4 aut
700a van Schie, Rianne M F4 aut
700a Wadelius, Miau Uppsala universitet,Klinisk farmakogenomik och osteoporos4 aut0 (Swepub:uu)miawadel
710a Uppsala universitetb Klinisk farmakogenomik och osteoporos4 org
773t Pharmacogenomics (London)d : Future Medicine Ltdg 11:7, s. 989-1002q 11:7<989-1002x 1462-2416x 1744-8042
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-151506
8564 8u https://doi.org/10.2217/pgs.10.74

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