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WFRF:(Kirilenko Bogdan M.)
 

Sökning: WFRF:(Kirilenko Bogdan M.) > Molecular paralleli...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004236naa a2200421 4500
001oai:DiVA.org:uu-369519
003SwePub
008181219s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3695192 URI
0247 a https://doi.org/10.1126/sciadv.aat96602 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lee, Jun-Hoeu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för cell- och molekylärbiologi,Max Planck Inst Mol Cell Biol & Genet, Dresden, Germany;Max Planck Inst Phys Komplexer Syst, Dresden, Germany;Ctr Syst Biol Dresden, Dresden, Germany4 aut0 (Swepub:uu)junle838
2451 0a Molecular parallelism in fast-twitch muscle proteins in echolocating mammals
264 1b American Association for the Advancement of Science (AAAS),c 2018
338 a electronic2 rdacarrier
520 a Detecting associations between genomic changes and phenotypic differences is fundamental to understanding how phenotypes evolved. By systematically screening for parallel amino acid substitutions, we detected known as well as novel cases (Strc, Tecta, and Cabp2) of parallelism between echolocating bats and toothed whales in proteins that could contribute to high-frequency hearing adaptations. Our screen also showed that echolocating mammals exhibit an unusually high number of parallel substitutions in fast-twitch muscle fiber proteins. Both echolocating bats and toothed whales produce an extremely rapid call rate when homing in on their prey, which was shown in bats to be powered by specialized superfast muscles. We show that these genes with parallel substitutions (Casq1, Atp2a1, Myh2, and Myl1) are expressed in the superfast sound-producing muscle of bats. Furthermore, we found that the calcium storage protein calsequestrin 1 of the little brown bat and the bottlenose dolphin functionally converged in its ability to form calcium-sequestering polymers at lower calcium concentrations, which may contribute to rapid calcium transients required for superfast muscle physiology. The proteins that our genomic screen detected could be involved in the convergent evolution of vocalization in echolocating mammals by potentially contributing to both rapid Ca2+ transients and increased shortening velocities in superfast muscles.
650 7a NATURVETENSKAPx Biologix Zoologi0 (SwePub)106082 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Zoology0 (SwePub)106082 hsv//eng
7001 a Lewis, Kevin M.u Washington State Univ, Dept Chem, Pullman, WA 99164 USA4 aut
7001 a Moural, Timothy W.u Washington State Univ, Dept Chem, Pullman, WA 99164 USA4 aut
7001 a Kirilenko, Bogdanu Max Planck Inst Mol Cell Biol & Genet, Dresden, Germany;Max Planck Inst Phys Komplexer Syst, Dresden, Germany;Ctr Syst Biol Dresden, Dresden, Germany4 aut
7001 a Borgonovo, Barbarau Max Planck Inst Mol Cell Biol & Genet, Dresden, Germany4 aut
7001 a Prange, Gisau Goethe Univ Frankfurt, Inst Cell Biol & Neurosci, Frankfurt, Germany4 aut
7001 a Koessl, Manfredu Goethe Univ Frankfurt, Inst Cell Biol & Neurosci, Frankfurt, Germany4 aut
7001 a Huggenberger, Stefanu Univ Cologne, Dept Anat Neuroanat, Cologne, Germany4 aut
7001 a Kang, ChulHeeu Washington State Univ, Dept Chem, Pullman, WA 99164 USA4 aut
7001 a Hiller, Michaelu Max Planck Inst Mol Cell Biol & Genet, Dresden, Germany;Max Planck Inst Phys Komplexer Syst, Dresden, Germany;Ctr Syst Biol Dresden, Dresden, Germany4 aut
7102 a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 org
7730 t Science Advancesd : American Association for the Advancement of Science (AAAS)g 4:9q 4:9x 2375-2548
8564 u https://doi.org/10.1126/sciadv.aat9660y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1272691/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://advances.sciencemag.org/content/advances/4/9/eaat9660.full.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-369519
8564 8u https://doi.org/10.1126/sciadv.aat9660

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