Using the Disease State Fingerprint Tool for Differential Diagnosis of Frontotemporal Dementia and Alzheimer's Disease

Munoz-Ruiz, Miguel Angel (författare): Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.

Hall, Anette (författare): Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.

Koikkalainen, Juha (författare): VTT Tech Res Ctr Finland, Tampere, Finland.

Herukka, Sanna-Kaisa (författare): Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland.

Hanninen, Tuomo (författare): Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland.

Vanninen, Ritva (författare): Kuopio Univ Hosp, Dept Radiol, Kuopio, Finland.

Liu, Yawu (författare): Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Radiol, Kuopio, Finland.

Hallikainen, Merja (författare): Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.

Remes, Anne M. (författare): Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland.

Alafuzoff, Irina (författare): Uppsala universitet,Experimentell och klinisk onkologi,Univ Uppsala Hosp, Rudbeck Lab, Dept Clin Surg Pathol, Uppsala, Sweden.

Soininen, Hilkka (författare): Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland.

Hartikainen, Paivi (författare): Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland.

Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland VTT Tech Res Ctr Finland, Tampere, Finland. (creator_code:org_t)

2016-07-22
2016
Engelska.
Ingår i: Dementia and Geriatric Cognitive Disorders Extra. - : S. Karger AG. - 1664-5464. ; 6:2, s. 313-329

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://www.karger.c...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Abstract Ämnesord

Stäng

Background: Disease State Index (DSI) and its visualization, Disease State Fingerprint (DSF), form a computer-assisted clinical decision making tool that combines patient data and compares them with cases with known outcomes. Aims: To investigate the ability of the DSI to diagnose frontotemporal dementia (FTD) and Alzheimer's disease (AD). Methods: The study cohort consisted of 38 patients with FTD, 57 with AD and 22 controls. Autopsy verification of FTD with TDP-43 positive pathology was available for 14 and AD pathology for 12 cases. We utilized data from neuropsychological tests, volumetric magnetic resonance imaging, single-photon emission tomography, cerebrospinal fluid biomarkers and the APOE genotype. The DSI classification results were calculated with a combination of leave-one-out cross-validation and bootstrapping. A DSF visualization of a FTD patient is presented as an example. Results: The DSI distinguishes controls from FTD (area under the receiver-operator curve, AUC = 0.99) and AD (AUC = 1.00) very well and achieves a good differential diagnosis between AD and FTD (AUC = 0.89). In subsamples of autopsy-confirmed cases (AUC = 0.97) and clinically diagnosed cases (AUC = 0.94), differential diagnosis of AD and FTD performs very well. Conclusions: DSI is a promising computer-assisted biomarker approach for aiding in the diagnostic process of dementing diseases. Here, DSI separates controls from dementia and differentiates between AD and FTD.

Av författaren/redakt...: Munoz-Ruiz, Migu ...; Hall, Anette; Mattila, Jussi; Koikkalainen, Ju ...; Herukka, Sanna-K ...; Husso, Minna; visa fler...; Hanninen, Tuomo; Vanninen, Ritva; Liu, Yawu; Hallikainen, Mer ...; Lotjonen, Jyrki; Remes, Anne M.; Alafuzoff, Irina; Soininen, Hilkka; Hartikainen, Pai ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Neurologi

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