WFRF:(Kozlova Elena N.)
Sökning: WFRF:(Kozlova Elena N.) > Dorsal Root Injury :
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03641naa a2200433 4500 | |
| 001 | oai:DiVA.org:uu-457743 | |
| 003 | SwePub | |
| 008 | 211112s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4577432 URI |
| 024 | 7 | a https://doi.org/10.3390/cells100921852 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a for2 swepub-publicationtype |
| 100 | 1 | a Aldskogius, Håkan,d 1943-u Uppsala universitet,Kozlova: Regenerativ neurobiologi4 aut0 (Swepub:uu)hakaalds |
| 245 | 1 0 | a Dorsal Root Injury :b A Model for Exploring Pathophysiology and Therapeutic Strategies in Spinal Cord Injury |
| 264 | c 2021-08-25 | |
| 264 | 1 | b MDPI,c 2021 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Unraveling the cellular and molecular mechanisms of spinal cord injury is fundamental for our possibility to develop successful therapeutic approaches. These approaches need to address the issues of the emergence of a non-permissive environment for axonal growth in the spinal cord, in combination with a failure of injured neurons to mount an effective regeneration program. Experimental in vivo models are of critical importance for exploring the potential clinical relevance of mechanistic findings and therapeutic innovations. However, the highly complex organization of the spinal cord, comprising multiple types of neurons, which form local neural networks, as well as short and long-ranging ascending or descending pathways, complicates detailed dissection of mechanistic processes, as well as identification/verification of therapeutic targets. Inducing different types of dorsal root injury at specific proximo-distal locations provide opportunities to distinguish key components underlying spinal cord regeneration failure. Crushing or cutting the dorsal root allows detailed analysis of the regeneration program of the sensory neurons, as well as of the glial response at the dorsal root-spinal cord interface without direct trauma to the spinal cord. At the same time, a lesion at this interface creates a localized injury of the spinal cord itself, but with an initial neuronal injury affecting only the axons of dorsal root ganglion neurons, and still a glial cell response closely resembling the one seen after direct spinal cord injury. In this review, we provide examples of previous research on dorsal root injury models and how these models can help future exploration of mechanisms and potential therapies for spinal cord injury repair. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a nerve regeneration | |
| 653 | a nerve degeneration | |
| 653 | a sensory neuron | |
| 653 | a astrocyte | |
| 653 | a microglia | |
| 653 | a gene regulation | |
| 653 | a trophic factor | |
| 653 | a transplantation | |
| 700 | 1 | a Kozlova, Elena N.u Uppsala universitet,Kozlova: Regenerativ neurobiologi4 aut0 (Swepub:uu)elenkozl |
| 710 | 2 | a Uppsala universitetb Kozlova: Regenerativ neurobiologi4 org |
| 773 | 0 | t Cellsd : MDPIg 10:9q 10:9x 2073-4409 |
| 856 | 4 | u https://doi.org/10.3390/cells10092185y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1610891/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://www.mdpi.com/2073-4409/10/9/2185/pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-457743 |
| 856 | 4 8 | u https://doi.org/10.3390/cells10092185 |
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