SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Kumar Keshav)
 

Search: WFRF:(Kumar Keshav) > Recent trends of NF...

Recent trends of NFkB decoy oligodeoxynucleotide-based nanotherapeutics in lung diseases

Mehta, Meenu (author)
Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW 2007, Australia.;Centenary Inst, Ctr Inflammat, Sydney, NSW 2050, Australia.;Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, Australia.
Paudel, Keshav Raj (author)
Centenary Inst, Ctr Inflammat, Sydney, NSW 2050, Australia.;Univ Technol Sydney, Sch Life Sci, Ultimo, NSW 2007, Australia.
Shukla, Shakti Dhar (author)
Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW 2007, Australia.;Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, Australia.
show more...
Allam, Venkata (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
Kannaujiya, Vinod Kumar (author)
Univ New South Wales, Sch Chem Engn, Sydney, NSW 2052, Australia.
Panth, Nisha (author)
Centenary Inst, Ctr Inflammat, Sydney, NSW 2050, Australia.
Das, Amlan (author)
Natl Inst Biomed Genom, Nadia 741235, WB, India.
Parihar, Vipan Kumar (author)
Univ Calif Irvine, NASA Specialized Ctr Res, Dept Radiat Oncol, Irvine, CA 92697 USA.
Chakraborty, Amlan (author)
Monash Univ, Biomed Discovery Inst, Dept Pharmacol, Melbourne, Vic 3800, Australia.
Ali, Md Khadem (author)
Stanford Univ, Dept Med, Div Pulm Allergy & Crit Care Med, Stanford, CA 94305 USA.;Stanford Univ, Vera Moulton Wall Ctr Pulm Vasc Dis, Stanford, CA 94305 USA.
Jha, Niraj Kumar (author)
Sharda Univ, Sch Engn & Technol SET, Dept Biotechnol, Greater Noida 201310, Uttar Pradesh, India.
Xenaki, Dikaia (author)
Univ Sydney, Woolcock Inst Med Res, Sydney, NSW, Australia.
Su, Qian Peter (author)
Univ Technol Sydney, Sch Biomed Engn, Fac Engn & Informat Technol, Sydney, NSW 2007, Australia.
Wich, Peter Richard (author)
Univ New South Wales, Sch Chem Engn, Sydney, NSW 2052, Australia.;Univ New South Wales, Australian Ctr NanoMed, Sydney, NSW 2052, Australia.;Univ New South Wales, Ctr Adv Macromol Design, Sydney, NSW 2052, Australia.
Adams, Jon (author)
Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, Australia.
Hansbro, Philip Michael (author)
Centenary Inst, Ctr Inflammat, Sydney, NSW 2050, Australia.;Univ Technol Sydney, Sch Life Sci, Ultimo, NSW 2007, Australia.
Chellappan, Dinesh Kumar (author)
Int Med Univ, Sch Pharm, Dept Life Sci, Kuala Lumpur 57000, Malaysia.
Oliver, Brian Gregory George (author)
Univ Technol Sydney, Sch Life Sci, Ultimo, NSW 2007, Australia.;Univ Sydney, Woolcock Inst Med Res, Sydney, NSW, Australia.
Dua, Kamal (author)
Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW 2007, Australia.;Centenary Inst, Ctr Inflammat, Sydney, NSW 2050, Australia.;Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, Australia.
show less...
Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW 2007, Australia;Centenary Inst, Ctr Inflammat, Sydney, NSW 2050, Australia.;Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, Australia. Centenary Inst, Ctr Inflammat, Sydney, NSW 2050, Australia.;Univ Technol Sydney, Sch Life Sci, Ultimo, NSW 2007, Australia. (creator_code:org_t)
Elsevier, 2021
2021
English.
In: Journal of Controlled Release. - : Elsevier. - 0168-3659 .- 1873-4995. ; 337, s. 629-644
Related links:
https://doi.org/10.1...
show more...
https://opus.lib.uts...
https://urn.kb.se/re...
https://doi.org/10.1...
show less...
  • Research review (peer-reviewed)
Abstract Subject headings
Close  
  • Nuclear factor Kappa B (NFicB) is a unique protein complex that plays a major role in lung inflammation and respi-ratory dysfunction. The NFicB signaling pathway, therefore becomes an avenue for the development of potential pharmacological interventions, especially in situations where chronic inflammation is often constitutively active and plays a key role in the pathogenesis and progression of the disease. NFicB decoy oligodeoxynucleotides (ODNs) are double-stranded and carry NFicB binding sequences. They prevent the formation of NFicB-mediated inflammatory cytokines and thus have been employed in the treatment of a variety of chronic inflammatory diseases. However, the systemic administration of naked decoy ODNs restricts their therapeutic effectiveness because of their poor pharmacokinetic profile, instability, degradation by cellular enzymes and their low cellular uptake. Both structural modification and nanotechnology have shown promising results in enhancing the pharmacokinetic profiles of potent therapeutic substances and have also shown great potential in the treatment of respiratory diseases such as asthma, chronic obstructive pulmonary disease and cystic fibrosis. In this review, we examine the contribution of NFicB activation in respiratory diseases and recent advancements in the thera-peutic use of decoy ODNs. In addition, we also highlight the limitations and challenges in use of decoy ODNs as therapeutic molecules, cellular uptake of decoy ODNs, and the current need for novel delivery systems to provide efficient delivery of decoy ODNs. Furthermore, this review provides a common platform for discussion on the existence of decoy ODNs, as well as outlining perspectives on the latest generation of delivery systems that encapsulate decoy ODNs and target NFxB in respiratory diseases.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)

Keyword

Nuclear factor kappa B
Decoy oligodeoxynucleotide
Respiratory disorder
Novel delivery systems

Publication and Content Type

ref (subject category)
for (subject category)

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view