Sökning: WFRF:(Löfgren Burström Anna) > (2015-2019) > TAP1 down-regulatio...
Fältnamn | Indikatorer | Metadata |
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000 | 03512naa a2200433 4500 | |
001 | oai:DiVA.org:umu-142377 | |
003 | SwePub | |
008 | 171129s2017 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1423772 URI |
024 | 7 | a https://doi.org/10.1080/2162402X.2017.13561432 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ling, Agnes,d 1976-u Umeå universitet,Patologi4 aut0 (Swepub:umu)agslig01 |
245 | 1 0 | a TAP1 down-regulation elicits immune escape and poor prognosis in colorectal cancer |
264 | 1 | c 2017 |
338 | a print2 rdacarrier | |
520 | a The anti-tumor immune response has been shown to be of great prognostic importance in colorectal cancer (CRC) and so has the tumors ability for immune evasion. Our aim of this study was to investigate tumor factors that influence immunity. We used a gene expression array to search for potential mechanisms of tumor immune escape. One candidate gene identified was TAP1, involved in antigen presentation by MHC class I. TAP1 protein expression was evaluated by immunohistochemistry in 436 CRC patients of the Colorectal Cancer in Umeå Study cohort. We found a significant association between a downregulated expression of TAP1 and low infiltration of various subtypes of lymphocytes as well as macrophages. A downregulated expression of TAP1 was further found to be independent of molecular characteristics, suggesting TAP1 down-regulation to reach beyond the well described highly immunogenic MSI CRCs. A low expression of TAP1 was also significantly associated with poor prognosis in patients with CRC, a result that stayed significant in tumor front of early stage tumors (stage I-II) through multivariable analyses. Furthermore, we found that TAP1 expression was inversely correlated with methylation at sites in close proximity to the promoter region. In summary, our results show down-regulation of TAP1 to be a general mechanism of tumor immune escape in CRC and a poor prognostic factor in stage I-II CRC patients. We also suggest that methylation of the TAP1 gene may be a putative mechanism for TAP1 downregulation. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a TAP1 | |
653 | a antigen presentation | |
653 | a colorectal cancer | |
653 | a immune escape | |
653 | a prognosis | |
700 | 1 | a Löfgren-Burström, Annau Umeå universitet,Patologi4 aut0 (Swepub:umu)anlo0002 |
700 | 1 | a Larsson, Päru Umeå universitet,Patologi4 aut0 (Swepub:umu)pala0006 |
700 | 1 | a Li, Xingruu Umeå universitet,Patologi4 aut0 (Swepub:umu)xili0010 |
700 | 1 | a Wikberg, Maria Lu Umeå universitet,Patologi4 aut0 (Swepub:umu)mahe0061 |
700 | 1 | a Öberg, Åkeu Umeå universitet,Kirurgi4 aut |
700 | 1 | a Stenling, Rogeru Umeå universitet,Patologi4 aut0 (Swepub:umu)rost0001 |
700 | 1 | a Edin, Sofiau Umeå universitet,Patologi4 aut0 (Swepub:umu)soed0001 |
700 | 1 | a Palmqvist, Richardu Umeå universitet,Patologi4 aut0 (Swepub:umu)ripa0001 |
710 | 2 | a Umeå universitetb Patologi4 org |
773 | 0 | t Oncoimmunologyg 6:11q 6:11x 2162-4011x 2162-402X |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-142377 |
856 | 4 8 | u https://doi.org/10.1080/2162402X.2017.1356143 |
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