WFRF:(Lagergren M.)
Sökning: WFRF:(Lagergren M.) > (2015-2019) > Immune activation b...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06102naa a2201477 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:142430259 | |
| 003 | SwePub | |
| 008 | 240818s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1424302592 URI |
| 024 | 7 | a https://doi.org/10.1136/gutjnl-2018-3176242 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Turkington, RC4 aut |
| 245 | 1 0 | a Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma |
| 264 | c 2019-03-09 | |
| 264 | 1 | b BMJ,c 2019 |
| 520 | a Current strategies to guide selection of neoadjuvant therapy in oesophageal adenocarcinoma (OAC) are inadequate. We assessed the ability of a DNA damage immune response (DDIR) assay to predict response following neoadjuvant chemotherapy in OAC.DesignTranscriptional profiling of 273 formalin-fixed paraffin-embedded prechemotherapy endoscopic OAC biopsies was performed. All patients were treated with platinum-based neoadjuvant chemotherapy and resection between 2003 and 2014 at four centres in the Oesophageal Cancer Clinical and Molecular Stratification consortium. CD8 and programmed death ligand 1 (PD-L1) immunohistochemical staining was assessed in matched resection specimens from 126 cases. Kaplan-Meier and Cox proportional hazards regression analysis were applied according to DDIR status for recurrence-free survival (RFS) and overall survival (OS).ResultsA total of 66 OAC samples (24%) were DDIR positive with the remaining 207 samples (76%) being DDIR negative. DDIR assay positivity was associated with improved RFS (HR: 0.61; 95% CI 0.38 to 0.98; p=0.042) and OS (HR: 0.52; 95% CI 0.31 to 0.88; p=0.015) following multivariate analysis. DDIR-positive patients had a higher pathological response rate (p=0.033), lower nodal burden (p=0.026) and reduced circumferential margin involvement (p=0.007). No difference in OS was observed according to DDIR status in an independent surgery-alone dataset.DDIR-positive OAC tumours were also associated with the presence of CD8+ lymphocytes (intratumoural: p<0.001; stromal: p=0.026) as well as PD-L1 expression (intratumoural: p=0.047; stromal: p=0.025).ConclusionThe DDIR assay is strongly predictive of benefit from DNA-damaging neoadjuvant chemotherapy followed by surgical resection and is associated with a proinflammatory microenvironment in OAC. | |
| 700 | 1 | a Knight, LA4 aut |
| 700 | 1 | a Blayney, JK4 aut |
| 700 | 1 | a Secrier, M4 aut |
| 700 | 1 | a Douglas, R4 aut |
| 700 | 1 | a Parkes, EE4 aut |
| 700 | 1 | a Sutton, EK4 aut |
| 700 | 1 | a Stevenson, L4 aut |
| 700 | 1 | a McManus, D4 aut |
| 700 | 1 | a Halliday, S4 aut |
| 700 | 1 | a McCavigan, AM4 aut |
| 700 | 1 | a Logan, GE4 aut |
| 700 | 1 | a Walker, SM4 aut |
| 700 | 1 | a Steele, CJ4 aut |
| 700 | 1 | a Perner, J4 aut |
| 700 | 1 | a Bornschein, J4 aut |
| 700 | 1 | a MacRae, S4 aut |
| 700 | 1 | a Miremadi, A4 aut |
| 700 | 1 | a McCarron, E4 aut |
| 700 | 1 | a McQuaid, S4 aut |
| 700 | 1 | a Arthur, K4 aut |
| 700 | 1 | a James, JA4 aut |
| 700 | 1 | a Eatock, MM4 aut |
| 700 | 1 | a O'Neill, R4 aut |
| 700 | 1 | a Noble, F4 aut |
| 700 | 1 | a Underwood, TJ4 aut |
| 700 | 1 | a Harkin, DP4 aut |
| 700 | 1 | a Salto-Tellez, M4 aut |
| 700 | 1 | a Fitzgerald, RC4 aut |
| 700 | 1 | a Kennedy, RD4 aut |
| 700 | 1 | a Noorani, A4 aut |
| 700 | 1 | a Edwards, PAW4 aut |
| 700 | 1 | a Grehan, N4 aut |
| 700 | 1 | a Nutzinger, B4 aut |
| 700 | 1 | a Hughes, C4 aut |
| 700 | 1 | a Fidziukiewicz, E4 aut |
| 700 | 1 | a Crawte, J4 aut |
| 700 | 1 | a Northrop, A4 aut |
| 700 | 1 | a Contino, G4 aut |
| 700 | 1 | a Li, XD4 aut |
| 700 | 1 | a de la Rue, R4 aut |
| 700 | 1 | a O'Donovan, M4 aut |
| 700 | 1 | a Malhotra, S4 aut |
| 700 | 1 | a Tripathi, M4 aut |
| 700 | 1 | a Tavare, S4 aut |
| 700 | 1 | a Lynch, AG4 aut |
| 700 | 1 | a Eldridge, M4 aut |
| 700 | 1 | a Bower, L4 aut |
| 700 | 1 | a Devonshire, G4 aut |
| 700 | 1 | a Jammula, S4 aut |
| 700 | 1 | a Davies, J4 aut |
| 700 | 1 | a Crichton, C4 aut |
| 700 | 1 | a Carroll, N4 aut |
| 700 | 1 | a Safranek, P4 aut |
| 700 | 1 | a Hindmarsh, A4 aut |
| 700 | 1 | a Sujendran, V4 aut |
| 700 | 1 | a Hayes, SJ4 aut |
| 700 | 1 | a Ang, Y4 aut |
| 700 | 1 | a Preston, SR4 aut |
| 700 | 1 | a Oakes, S4 aut |
| 700 | 1 | a Bagwan, I4 aut |
| 700 | 1 | a Save, V4 aut |
| 700 | 1 | a Skipworth, RJE4 aut |
| 700 | 1 | a Hupp, TR4 aut |
| 700 | 1 | a Tucker, O4 aut |
| 700 | 1 | a Beggs, A4 aut |
| 700 | 1 | a Taniere, P4 aut |
| 700 | 1 | a Puig, S4 aut |
| 700 | 1 | a Owsley, J4 aut |
| 700 | 1 | a Barr, H4 aut |
| 700 | 1 | a Shepherd, N4 aut |
| 700 | 1 | a Old, O4 aut |
| 700 | 1 | a Lagergren, Ju Karolinska Institutet4 aut |
| 700 | 1 | a Gossage, J4 aut |
| 700 | 1 | a Davies, A4 aut |
| 700 | 1 | a Chang, FJ4 aut |
| 700 | 1 | a Zylstra, J4 aut |
| 700 | 1 | a Mahadeva, U4 aut |
| 700 | 1 | a Goh, V4 aut |
| 700 | 1 | a Ciccarelli, FD4 aut |
| 700 | 1 | a Sanders, G4 aut |
| 700 | 1 | a Berrisford, R4 aut |
| 700 | 1 | a Harden, C4 aut |
| 700 | 1 | a Lewis, M4 aut |
| 700 | 1 | a Cheong, E4 aut |
| 700 | 1 | a Kumar, B4 aut |
| 700 | 1 | a Parsons, SL4 aut |
| 700 | 1 | a Soomro, I4 aut |
| 700 | 1 | a Kaye, P4 aut |
| 700 | 1 | a Saunders, J4 aut |
| 700 | 1 | a Lovat, L4 aut |
| 700 | 1 | a Haidry, R4 aut |
| 700 | 1 | a Igali, L4 aut |
| 700 | 1 | a Scott, M4 aut |
| 700 | 1 | a Sothi, S4 aut |
| 700 | 1 | a Suortamo, S4 aut |
| 700 | 1 | a Lishman, S4 aut |
| 700 | 1 | a Hanna, GB4 aut |
| 700 | 1 | a Moorthy, K4 aut |
| 700 | 1 | a Peters, CJ4 aut |
| 700 | 1 | a Grabowska, A4 aut |
| 700 | 1 | a Coleman, H4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Gutd : BMJg 68:11, s. 1918-1927q 68:11<1918-1927x 1468-3288x 0017-5749 |
| 856 | 4 | u https://gut.bmj.com/content/gutjnl/68/11/1918.full.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:142430259 |
| 856 | 4 8 | u https://doi.org/10.1136/gutjnl-2018-317624 |
Hitta mer i SwePub
- Av författaren/redakt...
- Turkington, RC
- Knight, LA
- Blayney, JK
- Secrier, M
- Douglas, R
- Parkes, EE
- visa fler...
- Sutton, EK
- Stevenson, L
- McManus, D
- Halliday, S
- McCavigan, AM
- Logan, GE
- Walker, SM
- Steele, CJ
- Perner, J
- Bornschein, J
- MacRae, S
- Miremadi, A
- McCarron, E
- McQuaid, S
- Arthur, K
- James, JA
- Eatock, MM
- O'Neill, R
- Noble, F
- Underwood, TJ
- Harkin, DP
- Salto-Tellez, M
- Fitzgerald, RC
- Kennedy, RD
- Noorani, A
- Edwards, PAW
- Grehan, N
- Nutzinger, B
- Hughes, C
- Fidziukiewicz, E
- Crawte, J
- Northrop, A
- Contino, G
- Li, XD
- de la Rue, R
- O'Donovan, M
- Malhotra, S
- Tripathi, M
- Tavare, S
- Lynch, AG
- Eldridge, M
- Bower, L
- Devonshire, G
- Jammula, S
- Davies, J
- Crichton, C
- Carroll, N
- Safranek, P
- Hindmarsh, A
- Sujendran, V
- Hayes, SJ
- Ang, Y
- Preston, SR
- Oakes, S
- Bagwan, I
- Save, V
- Skipworth, RJE
- Hupp, TR
- Tucker, O
- Beggs, A
- Taniere, P
- Puig, S
- Owsley, J
- Barr, H
- Shepherd, N
- Old, O
- Lagergren, J
- Gossage, J
- Davies, A
- Chang, FJ
- Zylstra, J
- Mahadeva, U
- Goh, V
- Ciccarelli, FD
- Sanders, G
- Berrisford, R
- Harden, C
- Lewis, M
- Cheong, E
- Kumar, B
- Parsons, SL
- Soomro, I
- Kaye, P
- Saunders, J
- Lovat, L
- Haidry, R
- Igali, L
- Scott, M
- Sothi, S
- Suortamo, S
- Lishman, S
- Hanna, GB
- Moorthy, K
- Peters, CJ
- Grabowska, A
- Coleman, H
- visa färre...
- Artiklar i publikationen
- Gut
- Av lärosätet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
