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Sökning: WFRF:(Lammertsma Adriaan A.) > Parametric Methods ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003319naa a2200481 4500
001oai:DiVA.org:uu-317725
003SwePub
008170317s2017 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3177252 URI
0247 a https://doi.org/10.2967/jnumed.116.1787072 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mansor, Syahir4 aut
2451 0a Parametric Methods for Dynamic (11)C-Phenytoin PET Studies.
264 c 2016-09-22
264 1b Society of Nuclear Medicine,c 2017
338 a print2 rdacarrier
520 a In this study, the performance of various methods for generating quantitative parametric images of dynamic (11)C-phenytoin PET studies was evaluated. Methods: Double-baseline 60-min dynamic (11)C-phenytoin PET studies, including online arterial sampling, were acquired for 6 healthy subjects. Parametric images were generated using Logan plot analysis, a basis function method, and spectral analysis. Parametric distribution volume (VT) and influx rate (K1) were compared with those obtained from nonlinear regression analysis of time-activity curves. In addition, global and regional test-retest (TRT) variability was determined for parametric K1 and VT values. Results: Biases in VT observed with all parametric methods were less than 5%. For K1, spectral analysis showed a negative bias of 16%. The mean TRT variabilities of VT and K1 were less than 10% for all methods. Shortening the scan duration to 45 min provided similar VT and K1 with comparable TRT performance compared with 60-min data. Conclusion: Among the various parametric methods tested, the basis function method provided parametric VT and K1 values with the least bias compared with nonlinear regression data and showed TRT variabilities lower than 5%, also for smaller volume-of-interest sizes (i.e., higher noise levels) and shorter scan duration.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
653 a 11C-phenytoin
653 a PET quantification
653 a parametric kinetic modeling
653 a test-retest variability
7001 a Yaqub, Maqsood4 aut
7001 a Boellaard, Ronald4 aut
7001 a Froklage, Femke E4 aut
7001 a de Vries, Anke4 aut
7001 a Bakker, Esther D M4 aut
7001 a Voskuyl, Rob A4 aut
7001 a Eriksson, Jonasu Uppsala universitet,Avdelningen för Molekylär Avbildning4 aut0 (Swepub:uu)joeri542
7001 a Schwarte, Lothar A4 aut
7001 a Verbeek, Joost4 aut
7001 a Windhorst, Albert D4 aut
7001 a Lammertsma, Adriaan A4 aut
7102 a Uppsala universitetb Avdelningen för Molekylär Avbildning4 org
7730 t Journal of Nuclear Medicined : Society of Nuclear Medicineg 58:3, s. 479-483q 58:3<479-483x 0161-5505x 1535-5667x 2159-662X
8564 u http://jnm.snmjournals.org/content/58/3/479.full.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-317725
8564 8u https://doi.org/10.2967/jnumed.116.178707

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