Sökning: WFRF:(Landberg Eva) > Identification of D...
Fältnamn | Indikatorer | Metadata |
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000 | 04284naa a2200481 4500 | |
001 | oai:gup.ub.gu.se/231783 | |
003 | SwePub | |
008 | 240528s2016 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2317832 URI |
024 | 7 | a https://doi.org/10.1016/j.stemcr.2015.12.0062 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Akrap, Ninau Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology4 aut0 (Swepub:gu)xakrni |
245 | 1 0 | a Identification of Distinct Breast Cancer Stem Cell Populations Based on Single-Cell Analyses of Functionally Enriched Stem and Progenitor Pools |
264 | 1 | b Elsevier BV,c 2016 |
520 | a The identification of breast cancer cell subpopulations featuring truly malignant stem cell qualities is a challenge due to the complexity of the disease and lack of general markers. By combining extensive single-cell gene expression profiling with three functional strategies for cancer stem cell enrichment including anchorage-independent culture, hypoxia, and analyses of low-proliferative, label-retaining cells derived from mammospheres, we identified distinct stem cell clusters in breast cancer. Estrogen receptor (ER)alpha+ tumors featured a clear hierarchical organization with switch-like and gradual transitions between different clusters, illustrating how breast cancer cells transfer between discrete differentiation states in a sequential manner. ER alpha- breast cancer showed less prominent clustering but shared a quiescent cancer stem cell pool with ER alpha+ cancer. The cellular organization model was supported by single-cell data from primary tumors. The findings allow us to understand the organization of breast cancers at the single-cell level, thereby permitting better identification and targeting of cancer stem cells. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a in-vitro propagation | |
653 | a expression | |
653 | a heterogeneity | |
653 | a subtypes | |
653 | a markers | |
653 | a tumors | |
653 | a aldh1 | |
653 | a state | |
653 | a lines | |
653 | a Cell Biology | |
700 | 1 | a Andersson, Daniel,d 1979u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Sahlgrenska Cancer Center,Institute of Biomedicine, Department of Pathology4 aut0 (Swepub:gu)xadanw |
700 | 1 | a Bom, Evau Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Sahlgrenska Cancer Center,Institute of Biomedicine, Department of Pathology4 aut0 (Swepub:gu)xdifev |
700 | 1 | a Gregersson, Pernillau Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Sahlgrenska Cancer Center,Institute of Biomedicine, Department of Pathology4 aut0 (Swepub:gu)xgregp |
700 | 1 | a Ståhlberg, Anders,d 1975u Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology4 aut0 (Swepub:gu)xsandw |
700 | 1 | a Landberg, Göran,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Sahlgrenska Cancer Center,Institute of Biomedicine, Department of Pathology4 aut0 (Swepub:gu)xlgora |
710 | 2 | a Göteborgs universitetb Sahlgrenska Cancer Center4 org |
773 | 0 | t Stem Cell Reportsd : Elsevier BVg 6:1, s. 121-136q 6:1<121-136x 2213-6711 |
856 | 4 | u http://www.cell.com/article/S2213671115003719/pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/231783 |
856 | 4 8 | u https://doi.org/10.1016/j.stemcr.2015.12.006 |
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