Fish oil delays lymphoma progression in the TLL mouse

Johansson, Ann-Sofie (författare): Umeå universitet,Medicinsk och klinisk genetik

Lindskog, Magnus (författare): Uppsala universitet,Karolinska Institutet,Enheten för onkologi,Klinisk farmakologi

(creator_code:org_t)

2010-10-04
2010
Engelska.
Ingår i: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 51:11, s. 2092-2097

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.3...; http://kipublication...; https://urn.kb.se/re...; visa färre...

Abstract Ämnesord

Stäng

The objective was to investigate the effects of omega-3 fatty acids, known for their anti-inflammatory effects, on time to lymphoma progression and survival in the TLL mouse, a strain genetically prone to developing aggressive T-cell lymphoma. Compared to mice fed a standard diet, TLL mice fed omega-3 (menhaden fish oil) experienced a significant delay in disease progression and were more likely to remain alive and symptom free during the first 8 months of the study. In contrast, omega-6 supplementation (corn oil) did not significantly affect lymphoma progression. Irrespective of diet, all mice eventually progressed, and 1-year survival was not different between the groups. Immunological analysis demonstrated a significantly altered B-cell compartment and fewer NK cells in healthy C57Black6 mice fed omega-3, compared to controls. In conclusion, a diet rich in omega-3 fatty acids delays lymphoma development in the TLL mouse possibly by mechanisms that include complex effects on immune function.

Av författaren/redakt...: Johansson, Ann-S ...; Norén-Nyström, U ...; Larefalk, Åsa; Holmberg, Dan; Lindskog, Magnus

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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