Associations between White Matter Microstructure and Cognitive Performance in Old and Very Old Age

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Laukka Erika Jonsson) > (2010-2014) > Associations betwee...

LIBRIS Formathandbok (Information om MARC21)

Details
MARC

Fältnamn	Indikatorer	Metadata
000		04367naa a2200469 4500
001		oai:DiVA.org:su-98304
003		SwePub
008		140103s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:127855445
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-983042 URI
024	7	a https://doi.org/10.1371/journal.pone.00814192 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1278554452 URI
040		a (SwePub)sud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Laukka, Erika J.u Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut
245	1 0	a Associations between White Matter Microstructure and Cognitive Performance in Old and Very Old Age
264		c 2013-11-25
264	1	b Public Library of Science (PLoS),c 2013
338		a print2 rdacarrier
500		a AuthorCount:8;
520		a Increasing age is associated with deficits in a wide range of cognitive domains as well as with structural brain changes. Recent studies using diffusion tensor imaging (DTI) have shown that microstructural integrity of white matter is associated with cognitive performance in elderly persons, especially on tests that rely on perceptual speed. We used structural equation modeling to investigate associations between white matter microstructure and cognitive functions in a population-based sample of elderly persons (age >= 60 years), free of dementia, stroke, and neurological disorders (n = 253). Participants underwent a magnetic resonance imaging scan, from which mean fractional anisotropy (FA) and mean diffusivity (MD) of seven white matter tracts were quantified. Cognitive functioning was analyzed according to performance in five task domains (perceptual speed, episodic memory, semantic memory, letter fluency, and category fluency). After controlling for age, FA and MD were exclusively related to perceptual speed. When further stratifying the sample into two age groups, the associations were reliable in the old-old (>= 78 years) only. This relationship between white matter microstructure and perceptual speed remained significant after excluding persons in a preclinical dementia phase. The observed pattern of results suggests that microstructural white matter integrity may be especially important to perceptual speed among very old adults.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Annan medicin och hälsovetenskapx Gerontologi, medicinsk/hälsovetenskaplig inriktning0 (SwePub)305022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Other Medical and Health Sciencesx Gerontology, specialising in Medical and Health Sciences0 (SwePub)305022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng
700	1	a Lövdén, Martinu Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut
700	1	a Kalpouzos, Gregoriau Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut
700	1	a Li, Tie-Qiangu Karolinska Institutet4 aut
700	1	a Jonsson, Tomasu Karolinska Institutet4 aut
700	1	a Wahlund, Lars-Olofu Karolinska Institutet4 aut
700	1	a Fratiglioni, Laurau Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut
700	1	a Bäckman, Larsu Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut
710	2	a Stockholms universitetb Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 org
773	0	t PLOS ONEd : Public Library of Science (PLoS)g 8:11q 8:11x 1932-6203
856	4	u https://doi.org/10.1371/journal.pone.0081419y Fulltext
856	4	u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0081419&type=printable
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-98304
856	4 8	u https://doi.org/10.1371/journal.pone.0081419
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:127855445

Find in a library

PLOS ONE (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Laukka, Erika J.; Lövdén, Martin; Kalpouzos, Grego ...; Li, Tie-Qiang; Jonsson, Tomas; Wahlund, Lars-Ol ...; show more...; Fratiglioni, Lau ...; Bäckman, Lars; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Other Medical an ...; and Gerontology spec ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Geriatrics

Articles in the publication: PLOS ONE

By the university: Stockholm University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se