Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

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Fältnamn	Indikatorer	Metadata
000		06453naa a2201345 4500
001		oai:lup.lub.lu.se:9f4ca94e-282a-49a3-98de-890883b7ea45
003		SwePub
008		160401s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/23792012 URI
024	7	a https://doi.org/10.1038/ng.10812 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Bellenguez, Celine4 aut
245	1 0	a Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
264		c 2012-02-05
264	1	b Springer Science and Business Media LLC,c 2012
520		a Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 x 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
700	1	a Bevan, Steve4 aut
700	1	a Gschwendtner, Andreas4 aut
700	1	a Spencer, Chris C. A.4 aut
700	1	a Burgess, Annette I.4 aut
700	1	a Pirinen, Matti4 aut
700	1	a Jackson, Caroline A.4 aut
700	1	a Traylor, Matthew4 aut
700	1	a Strange, Amy4 aut
700	1	a Su, Zhan4 aut
700	1	a Band, Gavin4 aut
700	1	a Syme, Paul D.4 aut
700	1	a Malik, Rainer4 aut
700	1	a Pera, Joanna4 aut
700	1	a Norrving, Bou Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-bno
700	1	a Lemmens, Robin4 aut
700	1	a Freeman, Colin4 aut
700	1	a Schanz, Renata4 aut
700	1	a James, Tom4 aut
700	1	a Poole, Deborah4 aut
700	1	a Murphy, Lee4 aut
700	1	a Segal, Helen4 aut
700	1	a Cortellini, Lynelle4 aut
700	1	a Cheng, Yu-Ching4 aut
700	1	a Woo, Daniel4 aut
700	1	a Nalls, Michael A.4 aut
700	1	a Mueller-Myhsok, Bertram4 aut
700	1	a Meisinger, Christa4 aut
700	1	a Seedorf, Udo4 aut
700	1	a Ross-Adams, Helen4 aut
700	1	a Boonen, Steven4 aut
700	1	a Wloch-Kopec, Dorota4 aut
700	1	a Valant, Valerie4 aut
700	1	a Slark, Julia4 aut
700	1	a Furie, Karen4 aut
700	1	a Delavaran, Hosseinu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-hmh
700	1	a Langford, Cordelia4 aut
700	1	a Deloukas, Panos4 aut
700	1	a Edkins, Sarah4 aut
700	1	a Hunt, Sarah4 aut
700	1	a Gray, Emma4 aut
700	1	a Dronov, Serge4 aut
700	1	a Peltonen, Leena4 aut
700	1	a Gretarsdottir, Solveig4 aut
700	1	a Thorleifsson, Gudmar4 aut
700	1	a Thorsteinsdottir, Unnur4 aut
700	1	a Stefansson, Kari4 aut
700	1	a Boncoraglio, Giorgio B.4 aut
700	1	a Parati, Eugenio A.4 aut
700	1	a Attia, John4 aut
700	1	a Holliday, Elizabeth4 aut
700	1	a Levi, Chris4 aut
700	1	a Franzosi, Maria-Grazia4 aut
700	1	a Goel, Anuj4 aut
700	1	a Helgadottir, Anna4 aut
700	1	a Blackwell, Jenefer M.4 aut
700	1	a Bramon, Elvira4 aut
700	1	a Brown, Matthew A.4 aut
700	1	a Casas, Juan P.4 aut
700	1	a Corvin, Aiden4 aut
700	1	a Duncanson, Audrey4 aut
700	1	a Jankowski, Janusz4 aut
700	1	a Mathew, Christopher G.4 aut
700	1	a Palmer, Colin N. A.4 aut
700	1	a Plomin, Robert4 aut
700	1	a Rautanen, Anna4 aut
700	1	a Sawcer, Stephen J.4 aut
700	1	a Trembath, Richard C.4 aut
700	1	a Viswanathan, Ananth C.4 aut
700	1	a Wood, Nicholas W.4 aut
700	1	a Worrall, Bradford B.4 aut
700	1	a Kittner, Steven J.4 aut
700	1	a Mitchell, Braxton D.4 aut
700	1	a Kissela, Brett4 aut
700	1	a Meschia, James F.4 aut
700	1	a Thijs, Vincent4 aut
700	1	a Lindgren, Arneu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-ali
700	1	a Macleod, Mary Joan4 aut
700	1	a Slowik, Agnieszka4 aut
700	1	a Walters, Matthew4 aut
700	1	a Rosand, Jonathan4 aut
700	1	a Sharma, Pankaj4 aut
700	1	a Farrall, Martin4 aut
700	1	a Sudlow, Cathie L. M.4 aut
700	1	a Rothwell, Peter M.4 aut
700	1	a Dichgans, Martin4 aut
700	1	a Donnelly, Peter4 aut
700	1	a Markus, Hugh S.4 aut
710	2	a Neurologi, Lundb Sektion IV4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 44:3, s. 141-328q 44:3<141-328x 1546-1718x 1061-4036
856	4	u http://dx.doi.org/10.1038/ng.1081y FULLTEXT
856	4	u https://www.pure.ed.ac.uk/ws/files/8324898/Genome_wide_association_study_identifies_a_variant_in_HDAC9_associated_with_large_vessel_ischemic_stroke.pdf
856	4 8	u https://lup.lub.lu.se/record/2379201
856	4 8	u https://doi.org/10.1038/ng.1081

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Av författaren/redakt...: Bellenguez, Celi ...; Bevan, Steve; Gschwendtner, An ...; Spencer, Chris C ...; Burgess, Annette ...; Pirinen, Matti; visa fler...; Jackson, Carolin ...; Traylor, Matthew; Strange, Amy; Su, Zhan; Band, Gavin; Syme, Paul D.; Malik, Rainer; Pera, Joanna; Norrving, Bo; Lemmens, Robin; Freeman, Colin; Schanz, Renata; James, Tom; Poole, Deborah; Murphy, Lee; Segal, Helen; Cortellini, Lyne ...; Cheng, Yu-Ching; Woo, Daniel; Nalls, Michael A ...; Mueller-Myhsok, ...; Meisinger, Chris ...; Seedorf, Udo; Ross-Adams, Hele ...; Boonen, Steven; Wloch-Kopec, Dor ...; Valant, Valerie; Slark, Julia; Furie, Karen; Delavaran, Hosse ...; Langford, Cordel ...; Deloukas, Panos; Edkins, Sarah; Hunt, Sarah; Gray, Emma; Dronov, Serge; Peltonen, Leena; Gretarsdottir, S ...; Thorleifsson, Gu ...; Thorsteinsdottir ...; Stefansson, Kari; Boncoraglio, Gio ...; Parati, Eugenio ...; Attia, John; Holliday, Elizab ...; Levi, Chris; Franzosi, Maria- ...; Goel, Anuj; Helgadottir, Ann ...; Blackwell, Jenef ...; Bramon, Elvira; Brown, Matthew A ...; Casas, Juan P.; Corvin, Aiden; Duncanson, Audre ...; Jankowski, Janus ...; Mathew, Christop ...; Palmer, Colin N. ...; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen ...; Trembath, Richar ...; Viswanathan, Ana ...; Wood, Nicholas W ...; Worrall, Bradfor ...; Kittner, Steven ...; Mitchell, Braxto ...; Kissela, Brett; Meschia, James F ...; Thijs, Vincent; Lindgren, Arne; Macleod, Mary Jo ...; Slowik, Agnieszk ...; Walters, Matthew; Rosand, Jonathan; Sharma, Pankaj; Farrall, Martin; Sudlow, Cathie L ...; Rothwell, Peter ...; Dichgans, Martin; Donnelly, Peter; Markus, Hugh S.; visa färre...

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