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Repeated centralize...
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Osterlund, PiaKarolinska Institutet,Tampere Univ Hosp, Dept Oncol, Teiskontie 35,POB 2000, Tampere 33520, Finland.;Univ Tampere, Tampere, Finland.;Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland.;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.
(författare)
Repeated centralized multidisciplinary team assessment of resectability, clinical behavior, and outcomes in 1086 Finnish metastatic colorectal cancer patients (RAXO) : A nationwide prospective intervention study
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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Elsevier,2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-446847
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-446847URI
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https://doi.org/10.1016/j.lanepe.2021.100049DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:154400671URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Resection of colorectal cancer (CRC) metastases provides good survival but is probably underused in real-world practice. Methods: A prospective Finnish nationwide study enrolled treatable metastatic CRC patients. The intervention was the assessment of resectability upfront and twice during first-line therapy by the multidisciplinary team (MDT) at Helsinki tertiary referral centre. The primary outcome was resection rates and survival. Findings: In 2012-2018, 1086 patients were included. Median follow-up was 58 months. Multiple metastatic sites were present in 500 (46%) patients at baseline and in 820 (76%) during disease trajectory. In MDT assessments, 447 (41%) were classified as resectable, 310 (29%) upfront and 137 (18%) after conversion therapy. Sixhundred and ninety curative intent resections or local ablative therapies (LAT) were performed in 399 patients (89% of 447 resectable). Multiple metastasectomies for multisite or later developing metastases were performed in 148 (37%) patients. Overall, 414 liver, 112 lung, 57 peritoneal, and 107 other metastasectomies were performed. Median OS was 80.4 months in R0/1-resected (HR 0.15; CI95% 0.12-0.19), 39.1 months in R2-resected/LAT (0.39; 0.29-0.53) patients, and 20.8 months in patients treated with "systemic therapy alone" (reference), with 5-year OS rates of 66%, 40%, and 6%, respectively. Interpretation: Repeated centralized MDT assessment in real-world metastatic CRC patients generates high resectability (41%) and resection rates (37%) with impressive survival, even when multisite metastases are present or develop later.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Salminen, TapioTampere Univ Hosp, Dept Oncol, Teiskontie 35,POB 2000, Tampere 33520, Finland.;Univ Tampere, Tampere, Finland.
(författare)
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Soveri, Leena-MaijaHelsinki Univ Hosp, Dept Oncol, Helsinki, Finland.;Hyvinkaa Hosp & Home Care, Dept Palliat Care, Hyvinkaa, Finland.
(författare)
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Kallio, RaijaOulu Univ Hosp, Dept Oncol, Oulu, Finland.;Univ Oulu, Oulu, Finland.
(författare)
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Kellokumpu, IlmoCent Hosp Cent Finland, Dept Gastrointestinal Surg, Jyyaskyla, Finland.
(författare)
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Lamminmäki, AnnamarjaKuopio Univ Hosp, Dept Oncol, Kuopio, Finland.;Univ Kuopio, Kuopio, Finland.
(författare)
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Halonen, PäiviHelsinki Univ Hosp, Dept Oncol, Helsinki, Finland.
(författare)
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Ristamäki, RaijaTurku Univ Hosp, Dept Oncol, Turku, Finland.;Univ Turku, Turku, Finland.
(författare)
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Lantto, EilaHelsinki Univ Hosp, Dept Radiol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.;Paijat Home Cent Hosp, Dept Radiol, Lahti, Finland.
(författare)
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Uutela, AkiUniv Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Dept Transplantat & Liver Surg, Helsinki, Finland.
(författare)
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Österlund, EmerikUppsala universitet,Experimentell och klinisk onkologi,Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Dept Transplantat & Liver Surg, Helsinki, Finland.;Akad Sjukhuset, Uppsala, Sweden.(Swepub:uu)emeos639
(författare)
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Ovissi, AliHelsinki Univ Hosp, Dept Radiol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
(författare)
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Nordin, ArnoUniv Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Dept Transplantat & Liver Surg, Helsinki, Finland.
(författare)
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Heervä, EetuTurku Univ Hosp, Dept Oncol, Turku, Finland.;Univ Turku, Turku, Finland.
(författare)
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Lehtomäki, KaisaTampere Univ Hosp, Dept Oncol, Teiskontie 35,POB 2000, Tampere 33520, Finland.;Univ Tampere, Tampere, Finland.
(författare)
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Räsänen, JariUniv Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Dept Thorac Surg, Helsinki, Finland.
(författare)
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Murashev, MaijaSatakunta Cent Hosp, Dept Oncol, Pori, Finland.
(författare)
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Aroviita, LauraKanta Hame Cent Hosp, Dept Oncol, Hameenlinna, Finland.
(författare)
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Jekunen, AnttiVaasa Cent Hosp, Dept Oncol, Vaasa, Finland.
(författare)
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Lindvall-Andersson, ReneeAland Cent Hosp, Dept Oncol, Mariehamn, Finland.
(författare)
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Nyandoto, PaulPaijat Name Cent Hosp, Dept Oncol, Lahti, Finland.
(författare)
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Kononen, JuhaCent Hosp Cent Finland, Dept Oncol, Jyvaskyla, Finland.
(författare)
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Lepistö, AnnaUniv Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Dept Gastrointestinal Surg, Helsinki, Finland.
(författare)
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Poussa, TuijaStatConsulting, Nokia, Finland.
(författare)
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Muhonen, TimoSouth Carelia Cent Hosp, Dept Oncol, Lappeenranta, Finland.
(författare)
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Ålgars, AnnikaTurku Univ Hosp, Dept Oncol, Turku, Finland.;Univ Turku, Turku, Finland.
(författare)
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Isoniemi, HelenaUniv Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Dept Transplantat & Liver Surg, Helsinki, Finland.
(författare)
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Karolinska InstitutetTampere Univ Hosp, Dept Oncol, Teiskontie 35,POB 2000, Tampere 33520, Finland.;Univ Tampere, Tampere, Finland.;Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland.;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:The Lancet Regional Health: Elsevier32666-7762
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Osterlund, Pia
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Salminen, Tapio
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Soveri, Leena-Ma ...
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Kallio, Raija
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Kellokumpu, Ilmo
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Lamminmäki, Anna ...
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visa fler...
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Halonen, Päivi
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Ristamäki, Raija
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Lantto, Eila
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Uutela, Aki
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Österlund, Emeri ...
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Ovissi, Ali
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Nordin, Arno
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Heervä, Eetu
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Lehtomäki, Kaisa
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Räsänen, Jari
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Murashev, Maija
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Aroviita, Laura
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Jekunen, Antti
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Lindvall-Anderss ...
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Nyandoto, Paul
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Kononen, Juha
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Lepistö, Anna
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Poussa, Tuija
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Muhonen, Timo
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Ålgars, Annika
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Isoniemi, Helena
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Uppsala universitet
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Karolinska Institutet