WFRF:(Lindberg Richard)
Sökning: WFRF:(Lindberg Richard) > (2010-2014) > Developmental expos...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04237naa a2200421 4500 | |
| 001 | oai:DiVA.org:umu-66379 | |
| 003 | SwePub | |
| 008 | 130219s2013 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-197413 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-663792 URI |
| 024 | 7 | a https://doi.org/10.1371/journal.pone.00550532 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1974132 URI |
| 040 | a (SwePub)umud (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Berg, Ceciliau Uppsala universitet,Miljötoxikologi4 aut0 (Swepub:uu)ceciberg |
| 245 | 1 0 | a Developmental exposure to fluoxetine modulates the serotonin system in hypothalamus |
| 264 | c 2013-01-28 | |
| 264 | 1 | b Public Library of Science (PLoS),c 2013 |
| 338 | a electronic2 rdacarrier | |
| 520 | a The selective serotonin reuptake inhibitor (SSRI) fluoxetine (FLU, Prozac®) is commonly prescribed for depression in pregnant women. This results in SSRI exposure of the developing fetus. However, there are knowledge gaps regarding the impact of SSRI exposure during development. Given the role of serotonin in brain development and its cross-talk with sex hormone function, we investigated effects of developmental exposure to pharmacologically relevant concentrations of FLU (3 and 30 nM (measured)) on brain neurotransmitter levels, gonadal differentiation, aromatase activity in brain and gonads, and the thyroid system, using the Xenopus tropicalis model. Tadpoles were chronically exposed (8 weeks) until metamorphosis. At metamorphosis brains were cryosectioned and levels of serotonin, dopamine, norepinephrine, and their metabolites 5-hydroxyindoleacetic acid, 3,4-dihydroxyphenylacetic acid, and homovanillic acid were measured in discrete regions (telencephalon, hypothalamus and the reticular formation) of the cryosections using high-performance liquid chromatography. Exposure to 30 nM FLU increased the concentration of 5-hydroxyindoleacetic acid in hypothalamus compared with controls. FLU exposure did not affect survival, time to metamorphosis, thyroid histology, gonadal sex differentiation, or aromatase activity implying that the effect on the serotonergic neurotransmitter system in the hypothalamus region was specific. The FLU concentration that impacted the serotonin system is lower than the concentration measured in umbilical cord serum, suggesting that the serotonin system of the developing brain is highly sensitive to in utero exposure to FLU. To our knowledge this is the first study showing effects of developmental FLU exposure on brain neurochemistry. Given that SSRIs are present in the aquatic environment the current results warrant further investigation into the neurobehavioral effects of SSRIs in aquatic wildlife. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng |
| 700 | 1 | a Bäckström, Tobiasu Uppsala universitet,Jämförande fysiologi4 aut |
| 700 | 1 | a Winberg, Svanteu Uppsala universitet,Fysiologi4 aut0 (Swepub:uu)svanwinb |
| 700 | 1 | a Lindberg, Richardu Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)rili0003 |
| 700 | 1 | a Brandt, Ingvaru Uppsala universitet,Miljötoxikologi4 aut0 (Swepub:uu)ingvbran |
| 710 | 2 | a Uppsala universitetb Miljötoxikologi4 org |
| 773 | 0 | t PLOS ONEd : Public Library of Science (PLoS)g 8:1q 8:1x 1932-6203 |
| 856 | 4 | u https://doi.org/10.1371/journal.pone.0055053y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:606376/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0055053&type=printable |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:613084/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-66379 |
| 856 | 4 8 | u https://doi.org/10.1371/journal.pone.0055053 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-197413 |
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