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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003573nam a2200349 4500
001oai:DiVA.org:uu-374153
003SwePub
008190118| | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3741532 URI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a ovr2 swepub-publicationtype
1001 a Asif, Sana,c M.D, PhD studentu Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)sanas317
2451 0a Validation of an MPC polymer coating to reduce surface-induced cascade system activation in whole blood in in vitroand in vivo models
338 a print2 rdacarrier
520 a ABSTRACTBackground: Artificial surfaces that come into contact with blood (e.g., when used in various forms of biomedical device) induce an immediate activation of the cascade systems of the blood, the coagulation and complement systems. These reactions may lead to a thrombotic and/or inflammatory response that can eventually cause damage to the biomaterial or the patient, or to both. Multiple strategies to dampen these reactions have been employed, with heparin conjugation to the material surface being the most successfulthus far. Another approach to improving hemocompatibility is to use 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymer coatings.Experimental: In the present study, we evaluated the effectiveness of MPC polymer coating and compared it to a commercially available heparin coating in various in vitromodels using fresh human blood with the aim to replace the costly heparin-coated equipment with the more economic MPC. We then investigated the stability of the various coatings in human plasma in vitrofor 2 weeks. Finally, we inserted MPC polymer-coated catheters into the external jugular vein of pigs and monitored the catheters’ antithrombotic properties for 4 days.Results: 1) There was no significant activation of platelets and of the coagulation and complement systems on the MPC polymer-coated or the commercially available heparin surface. 2) Both coats were superior in hemocompatibility to non-coated matrix surfaces. 3) The protective effect of the MPC polymer coat did not decline after incubation in plasma for up to 2 weeks. 4) With MPC polymer-coated catheters, it was possible to easily draw blood from experimental animals for 4 days, in contrast to the case for heparin-flushed commercially available non-coated catheters, in which substantial clotting was seen.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng
7001 a Asawa, Kenta4 aut
7001 a Yuuki, Inoue4 aut
7001 a Kazuhiko, Ishihara24 aut
7001 a Lindell, Björnu Uppsala universitet,Käkkirurgi4 aut0 (Swepub:uu)bjoli788
7001 a Holmgren, Robinu Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut
7001 a Nilsson, Bou Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)bonils
7001 a Ryden, Anneli4 aut
7001 a Wearn, Marinne Jensen4 aut
7001 a Teramura, Yujiu Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)yujte186
7001 a Nilsson Ekdahl, Kristinau Uppsala universitet,Klinisk immunologi,Fasta tillståndets fysik4 aut0 (Swepub:uu)krisnil
7102 a Uppsala universitetb Klinisk immunologi4 org
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-374153

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