RENEB biodosimetry intercomparison analyzing translocations by FISH

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Lindholm Carita) > RENEB biodosimetry ...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		04036naa a2200625 4500
001		oai:DiVA.org:su-140231
003		SwePub
008		170306s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1402312 URI
024	7	a https://doi.org/10.1080/09553002.2016.12220922 DOI
040		a (SwePub)su
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Francesc Barquinero, Joan4 aut
245	1 0	a RENEB biodosimetry intercomparison analyzing translocations by FISH
264		c 2016-10-05
264	1	b Informa UK Limited,c 2017
338		a print2 rdacarrier
520		a Purpose: In the framework of RENEB, several biodosimetry exercises were conducted analyzing different endpoints. Among them, the analysis of translocations is considered the most useful method for retrospective biodosimetry due to the relative stability of their frequency with post irradiation time. The aim of this study was to harmonize the accuracy of translocation-based biodosimetry within the RENEB consortium. Materials and methods: An initial telescoring exercise analyzing FISH metaphase images was done to harmonize chromosome aberration descriptions. Then two blind intercomparison exercises (IE) were performed, by sending irradiated blood samples to each partner. Samples were cultured and stained by each partner using their standard protocol and translocation frequency was used to produce dose estimates. Results: The coefficient of variation in the 1st IE (CV = 0.34) was higher than in the 2nd IE (CV = 0.16 and 0.23 in the two samples analyzed), for the genomic frequency of total translocations. Z-score analysis revealed that eight out of 10 and 17 out of 20 dose estimates were satisfactory in the 1st and 2nd IE, respectively. Conclusions: The results obtained indicate that, despite the problems identified in few partners, which can be corrected, the RENEB consortium is able to carry out retrospective biodosimetry analyzing the frequency of translocations by FISH.
650	7	a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
650	7	a TEKNIK OCH TEKNOLOGIERx Maskinteknik0 (SwePub)2032 hsv//swe
650	7	a ENGINEERING AND TECHNOLOGYx Mechanical Engineering0 (SwePub)2032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
653		a Biodosimetry
653		a FISH
653		a RENEB
653		a translocations
700	1	a Beinke, Christina4 aut
700	1	a Borras, Mireia4 aut
700	1	a Buraczewska, Iwona4 aut
700	1	a Darroudi, Firouz4 aut
700	1	a Gregoire, Eric4 aut
700	1	a Hristova, Rositsa4 aut
700	1	a Kulka, Ulrike4 aut
700	1	a Lindholm, Carita4 aut
700	1	a Moreno, Mercedes4 aut
700	1	a Moquet, Jayne4 aut
700	1	a Oestreicher, Ursula4 aut
700	1	a Jesus Prieto, M.4 aut
700	1	a Pujol, Monica4 aut
700	1	a Ricoul, Michelle4 aut
700	1	a Sabatier, Laure4 aut
700	1	a Sommer, Sylwester4 aut
700	1	a Sun, Mingzhu4 aut
700	1	a Wojcik, Andrzeju Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)anwoj
700	1	a Barrios, Leonardo4 aut
710	2	a Stockholms universitetb Institutionen för molekylär biovetenskap, Wenner-Grens institut4 org
773	0	t International Journal of Radiation Biologyd : Informa UK Limitedg 93:1, s. 30-35q 93:1<30-35x 0955-3002x 1362-3095
856	4	u https://www.tandfonline.com/doi/pdf/10.1080/09553002.2016.1222092?needAccess=true
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-140231
856	4 8	u https://doi.org/10.1080/09553002.2016.1222092

Hitta via bibliotek

International Journal of Radiation Biology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Om ämnet

NATURVETENSKAP: NATURVETENSKAP; och Biologi

TEKNIK OCH TEKNOLOGIER: TEKNIK OCH TEKNO ...; och Maskinteknik

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Radiologi och bi ...

Artiklar i publikationen: International Jo ...

Av lärosätet: Stockholms universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se