PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation

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Fältnamn	Indikatorer	Metadata
000		04942naa a2200637 4500
001		oai:lup.lub.lu.se:abbd18ad-fc8f-48b1-af50-6d8a1802f25f
003		SwePub
008		240213s2024 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/abbd18ad-fc8f-48b1-af50-6d8a1802f25f2 URI
024	7	a https://doi.org/10.1158/1541-7786.MCR-23-01152 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Chen, Hongxiau Northwestern University,Chongqing University4 aut
245	1 0	a PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation
264	1	c 2024
300		a 10 s.
520		a Receptor tyrosine kinase KIT is frequently activated in acute myeloid leukemia (AML). While high PRL2 (PTP4A2) expression is correlated with activation of SCF/KIT signaling in AML, the underlying mechanisms are not fully understood. We discovered that inhibition of PRL2 significantly reduces the burden of oncogenic KIT-driven leukemia and extends leukemic mice survival. PRL2 enhances oncogenic KIT signaling in leukemia cells, promoting their proliferation and survival. We found that PRL2 dephosphorylates CBL at tyrosine 371 and inhibits its activity toward KIT, leading to decreased KIT ubiquitination and enhanced AKT and ERK signaling in leukemia cells.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Bai, Yunpengu Purdue University4 aut
700	1	a Kobayashi, Michihirou Indiana University4 aut
700	1	a Xiao, Shiyuu Northwestern University4 aut
700	1	a Barajas, Sergiou Northwestern University,Indiana University4 aut
700	1	a Cai, Wenjieu Indiana University,Northwestern University4 aut
700	1	a Chen, Sisiu Indiana University4 aut
700	1	a Miao, Jinminu Purdue University4 aut
700	1	a Meke, Frederick Ngueleu Purdue University4 aut
700	1	a Yao, Chonghuau Indiana University4 aut
700	1	a Yang, Yuxiau Peking University,Indiana University4 aut
700	1	a Strube, Katherineu Indiana University4 aut
700	1	a Satchivi, Odeliau Indiana University4 aut
700	1	a Sun, Jianminu Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)expk-jsu
700	1	a Ronnstrand, Larsu Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Molekylär cancerforskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Molecular Cancer Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 aut0 (Swepub:lu)klke-lro
700	1	a Croop, James M.u Indiana University4 aut
700	1	a Boswell, H. Scottu Indiana University4 aut
700	1	a Jia, Yuzhiu Northwestern University4 aut
700	1	a Liu, Huipingu Northwestern University Feinberg School of Medicine,Northwestern University4 aut
700	1	a Li, Loretta S.u Northwestern University,Northwestern University Feinberg School of Medicine4 aut
700	1	a Altman, Jessica K.u Northwestern University Feinberg School of Medicine,Northwestern University4 aut
700	1	a Eklund, Elizabeth A.u Jesse Brown VA Medical Center,Northwestern University Feinberg School of Medicine,Northwestern University4 aut
700	1	a Sukhanova, Madinau Northwestern University4 aut
700	1	a Ji, Pengu Northwestern University Feinberg School of Medicine,Northwestern University4 aut
700	1	a Tong, Weiu The Children's Hospital of Philadelphia4 aut
700	1	a Band, Hamidu University of Nebraska Medical Center4 aut
700	1	a Huang, Danny T.u Glasgow Royal Infirmary4 aut
700	1	a Platanias, Leonidas C.u Jesse Brown VA Medical Center,Northwestern University Feinberg School of Medicine,Northwestern University4 aut
700	1	a Zhang, Zhong Yinu Purdue University4 aut
700	1	a Liu, Yanu Northwestern University,Northwestern University Feinberg School of Medicine4 aut
710	2	a Northwestern Universityb Chongqing University4 org
773	0	t Molecular Cancer Researchg 22:1, s. 94-103q 22:1<94-103x 1541-7786
856	4	u http://dx.doi.org/10.1158/1541-7786.MCR-23-0115y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/abbd18ad-fc8f-48b1-af50-6d8a1802f25f
856	4 8	u https://doi.org/10.1158/1541-7786.MCR-23-0115

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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