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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04011naa a2200385 4500 | |
| 001 | oai:DiVA.org:uu-304603 | |
| 003 | SwePub | |
| 008 | 161006s2015 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3046032 URI |
| 024 | 7 | a https://doi.org/10.1016/j.jinf.2014.12.0142 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ljunghill Hedberg, Annau Uppsala universitet,Infektionssjukdomar4 aut0 (Swepub:uu)annlj496 |
| 245 | 1 0 | a Lower response to early T-cell-dependent vaccination after neurotrauma or neurosurgery in adults |
| 264 | 1 | b Elsevier BV,c 2015 |
| 338 | a print2 rdacarrier | |
| 520 | a Background: Recent international guidelines recommend vaccination with a 13-valent pneumococcal conjugate vaccine to reduce the risk of meningitis after neurotrauma with cerebrospinal fluid leak. The antibody response and optimal time point for vaccination have not been established and because the risk of meningitis is at the highest shortly after trauma, early vaccination is preferable. This study aimed to investigate the antibody response and to ensure that central nervous system injury-induced immunodepression did not affect the response to a T-cell-dependent conjugate vaccine when administered shortly after the injury. Methods: So as not to interfere with routine pneumococcal vaccination, a conjugate vaccine against Haemophilus influenza type b (Hib) was chosen for the study. Thirty-three patients with basilar skull fracture and 23 patients undergoing transsphenoidal pituitary gland surgery were vaccinated within 10 days after trauma/surgery and 29 control patients at least three weeks after trauma/surgery. Sera were collected pre- and post-vaccination for analysis of anti-Hib concentration. Results: Four patients with post-vaccination target antibody concentration before vaccination were excluded from analysis. In the neurotrauma and neurosurgery groups 10/32 (31%) and 5/20 (25%) patients, respectively, were non-responders compared with 3/29 (10%) in the control group. Log(10) anti-Hib concentrations in the neurotrauma, neurosurgery and control groups were 1.52 +/- 0.15, 1.38 +/- 0.15 and 1.81 +/- 0.12 mu g/ml, respectively. Conclusions: The majority of the patients responded to vaccination. However, the number of responders was significantly decreased and antibody concentration significantly lower in patients vaccinated early after the trauma/surgery. Investigation of the pneumococcal conjugate vaccine response in neurotrauma patients is therefore urgent. (C) 2015 The British Infection Association. Published by Elsevier Ltd. All rights reserved. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
| 653 | a Neurotrauma | |
| 653 | a Meningitis | |
| 653 | a Conjugate vaccine | |
| 700 | 1 | a Pauksen, Karlisu Uppsala universitet,Infektionssjukdomar4 aut0 (Swepub:uu)karlpauk |
| 700 | 1 | a Ronne-Engström, Elisabethu Uppsala universitet,Neurokirurgi4 aut0 (Swepub:uu)elisronn |
| 700 | 1 | a Lundberg, Mariau Uppsala universitet,Infektionssjukdomar,Uppsala Univ, Infect Dis Sect, Dept Med Sci, Uppsala, Sweden.4 aut0 (Swepub:uu)marlu733 |
| 700 | 1 | a Johansson, Bjornu Uppsala universitet,Rehabiliteringsmedicin,Uppsala Univ, Sect Rehabil Med, Dept Neurosci, Uppsala, Sweden.4 aut |
| 700 | 1 | a Kayhty, Helenau Natl Inst Hlth & Welf, Helsinki, Finland.4 aut |
| 700 | 1 | a Sjölin, Janu Uppsala universitet,Infektionssjukdomar4 aut0 (Swepub:uu)jasjo255 |
| 710 | 2 | a Uppsala universitetb Infektionssjukdomar4 org |
| 773 | 0 | t Journal of Infectiond : Elsevier BVg 70:6, s. 577-584q 70:6<577-584x 0163-4453x 1532-2742 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-304603 |
| 856 | 4 8 | u https://doi.org/10.1016/j.jinf.2014.12.014 |
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