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PR interval genome-...
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity
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- van Setten, Jessica (author)
- Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, NL-3584 CX Utrecht, Netherlands
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- Brody, Jennifer A. (author)
- Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA
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- Jamshidi, Yalda (author)
- St Georges Univ London, Cardiogenet Lab, Mol & Clin Sci Res Inst, London SW17 0RE, England
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- Swenson, Brenton R. (author)
- Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA;Univ Washington, Inst Publ Hlth Genet, Sch Publ Hlth, Seattle, WA 98195 USA
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- Butler, Anne M. (author)
- Washington Univ, Sch Med, Div Infect Dis, St Louis, MO 63110 USA
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- Campbell, Harry (author)
- Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh EH8 9YL, Midlothian, Scotland
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- Del Greco, Fabiola M. (author)
- Univ Lubeck, Inst Biomed, Affiliated Inst, Eurac Res, I-39100 Bolzano, Italy
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- Evans, Daniel S. (author)
- Calif Pacific Med Ctr, Res Inst, San Francisco, CA 94107 USA
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- Gibson, Quince (author)
- Univ Alabama Birmingham Hosp, Dept Surg, Birmingham, AL 35233 USA
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- Gudbjartsson, Daniel F. (author)
- DeCODE Genet Amgen Inc, IS-101 Reykjavik, Iceland;Univ Iceland, Sch Engn & Nat Sci, IS-101 Reykjavik, Iceland
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- Kerr, Kathleen F. (author)
- Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA
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- Krijthe, Bouwe P. (author)
- Erasmus MC, Dept Epidemiol, NL-3015 GD Rotterdam, Netherlands
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- Lyytikainen, Leo-Pekka (author)
- Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland;Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere 33014, Finland
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- Mueller, Christian (author)
- Univ Heart Ctr Hamburg Eppendorf, Dept Gen & Intervent Cardiol, D-20251 Hamburg, Germany;DZHK German Ctr Cardiovasc Res, Partner Site, Hamburg, Germany
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- Mueller-Nurasyid, Martina (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, D-85764 Neuherberg, Germany;Hosp Ludwig Maximilians Univ LMU Munich, Dept Internal Med Cardiol 1, D-81377 Munich, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80802 Munich, Germany;Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9713GZ Groningen, Netherlands
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- Nolte, Ilja M. (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9713GZ Groningen, Netherlands
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- Padmanabhan, Sandosh (author)
- Univ Glasgow, Coll Med Vet & Life Sci, Inst Cardiovasc & Med Sci, Glasgow G12 8TA, Lanark, Scotland
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- Ritchie, Marylyn D. (author)
- Univ Penn, Dept Genet, Philadelphia, PA 19104 USA
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- Robino, Antonietta (author)
- IRCCS Burlo Garofolo, Inst Maternal & Child Health, I-34137 Trieste, Italy
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- Smith, Albert V. (author)
- Iceland Heart Assoc, IS-201 Kopavogur, Iceland;Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland;Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA
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- Steri, Maristella (author)
- CNR, Ist Ric Genet & Biomed, I-00185 Cagliari, Italy
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- Tanaka, Toshiko (author)
- NIA, Translat Gerontol Branch, Bethesda, MD 20892 USA
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- Teumer, Alexander (author)
- Univ Med Greifswald, Inst Community Med, D-17489 Greifswald, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany
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- Trompet, Stella (author)
- Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands;Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, NL-2300 RC Leiden, Netherlands
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- Ulivi, Sheila (author)
- IRCCS Burlo Garofolo, Inst Maternal & Child Health, I-34137 Trieste, Italy
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- Verweij, Niek (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-7913GZ Groningen, Netherlands
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- Yin, Xiaoyan (author)
- Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA
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- Arnar, David O. (author)
- DeCODE Genet Amgen Inc, IS-101 Reykjavik, Iceland;Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland;Landspitali Univ Hosp, Dept Med, IS-101 Reykjavik, Iceland
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- Asselbergs, Folkert W. (author)
- Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, NL-3584 CX Utrecht, Netherlands;Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands;UCL, Fac Populat Hlth Sci, Inst Cardiovasc Sci, London WC1E 6BT, England;UCL, Farr Inst Hlth Informat Res, London WC1E 6BT, England;UCL, Inst Hlth Informat, London WC1E 6BT, England
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- Bader, Joel S. (author)
- Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA
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- Barnard, John (author)
- Cleveland Clin, Lerner Res Inst, Dept Quantitat Hlth Sci, Cleveland, OH 44195 USA
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- Bis, Josh (author)
- Univ Heart Ctr Hamburg Eppendorf, Dept Gen & Intervent Cardiol, D-20251 Hamburg, Germany;DZHK German Ctr Cardiovasc Res, Partner Site, Hamburg, Germany
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- Blankenberg, Stefan (author)
- DZHK German Ctr Cardiovasc Res, Partner Site, Hamburg, Germany;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, D-85764 Neuherberg, Germany
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- Boerwinkle, Eric (author)
- Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Houston, TX 77030 USA
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- Bradford, Yuki (author)
- Univ Penn, Dept Genet, Philadelphia, PA 19104 USA
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- Buckley, Brendan M. (author)
- Univ Coll Cork, Dept Pharmacol & Therapeut, Cork T12 K8AF, Ireland
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- Chung, Mina K. (author)
- Cleveland Clin, Heart & Vasc Inst, Dept Cardiovasc Med, Cleveland, OH 44195 USA;Cleveland Clin, Lerner Res Inst, Dept Mol Cardiol, Cleveland, OH 44195 USA
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- Crawford, Dana (author)
- Case Western Reserve Univ, Inst Computat Biol, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA
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- den Hoed, Marcel (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Denny, Josh C. (author)
- Vanderbilt Univ, Biomed Informat & Med, 221 Kirkland Hall, Nashville, TN 37235 USA
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- Dominiczak, Anna F. (author)
- Univ Glasgow, Coll Med Vet & Life Sci, Inst Cardiovasc & Med Sci, Glasgow G12 8TA, Lanark, Scotland
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- Ehret, Georg B. (author)
- Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Ctr Complex Dis Genom, Baltimore, MD 21287 USA
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- Eijgelsheim, Mark (author)
- Erasmus MC, Dept Epidemiol, NL-3015 GD Rotterdam, Netherlands;Univ Med Ctr Groningen, Dept Nephrol, NL-7913GZ Groningen, Netherlands
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- Ellinor, Patrick T. (author)
- Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA;Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA
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- Felix, Stephan B. (author)
- DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany;Univ Med Greifswald, Dept Internal Med B, D-17489 Greifswald, Germany
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- Franco, Oscar H. (author)
- Erasmus MC, Dept Epidemiol, NL-3015 GD Rotterdam, Netherlands
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- Franke, Lude (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-7913GZ Groningen, Netherlands
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- Harris, Tamara B. (author)
- NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH, Bethesda, MD 20892 USA
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- Holm, Hilma (author)
- DeCODE Genet Amgen Inc, IS-101 Reykjavik, Iceland
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- Ilaria, Gandin (author)
- Univ Trieste, Dept Med Sci, I-34127 Trieste, Italy
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- Iorio, Annamaria (author)
- Osped Riuniti, Cardiovasc Dept, I-34124 Trieste, Italy;Univ Trieste, I-34124 Trieste, Italy
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- Kahonen, Mika (author)
- Tampere Univ Hosp, Dept Clin Physiol, Tampere 33521, Finland;Univ Tampere, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Life Sci, Dept Clin Physiol, Tampere 33014, Finland
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- Kolcic, Ivana (author)
- Univ Split, Fac Med, Split 21000, Croatia
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- Kors, Jan A. (author)
- Erasmus Univ, Med Ctr, Dept Med Informat, NL-3015 GD Rotterdam, Netherlands
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- Lakatta, Edward G. (author)
- NIA, Lab Cardiovasc Sci, NIH, Bethesda, MD 20892 USA
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- Launer, Lenore J. (author)
- NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH, Bethesda, MD 20892 USA
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- Lin, Honghuang (author)
- Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA
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- Lin, Henry J. (author)
- Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA 90502 USA
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- Loos, Ruth J. F. (author)
- Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA
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- Lubitz, Steven A. (author)
- Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA;Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA
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- Macfarlane, Peter W. (author)
- Univ Glasgow, Inst Hlth & Wellbeing, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
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- Magnani, Jared W. (author)
- Univ Pittsburgh, Med Ctr, Heart & Vasc Inst, Dept Med,Div Cardiol, Pittsburgh, PA 15260 USA
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- Leach, Irene Mateo (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-7913GZ Groningen, Netherlands
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- Meitinger, Thomas (author)
- DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80802 Munich, Germany;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Human Genet, D-85764 Neuherberg, Germany;Tech Univ Munich, Klinikum Rechts Isar, Inst Human Genet, D-81675 Munich, Germany
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- Mitchell, Braxton D. (author)
- Univ Maryland, Geriatr Res & Educ Clin Ctr, Baltimore VA Med Ctr, Dept Med,Sch Med, Baltimore, MD 21201 USA
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- Munzel, Thomas (author)
- Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Cardiol, D-55131 Mainz, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Rhine Main, D-55131 Mainz, Germany;Johannes Gutenberg Univ Mainz, Univ Med Ctr, CTVB, D-55131 Mainz, Germany
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- Papanicolaou, George J. (author)
- NHLBI, Div Cardiovasc Sci, NIH, Bethesda, MD 20892 USA
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- Peters, Annette (author)
- DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80802 Munich, Germany;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, D-85764 Neuherberg, Germany;German Ctr Diabet Res, D-85764 Neuherberg, Germany
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- Pfeufer, Arne (author)
- MVZ Molekulardiagnost, D-81543 Munich, Germany
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- Pramstaller, Peter P. (author)
- Univ Lubeck, Inst Biomed, Affiliated Inst, Eurac Res, I-39100 Bolzano, Italy;Cent Hosp, Dept Neurol, I-39100 Bolzano, Italy
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- Raitakari, Olli T. (author)
- Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku 20521, Finland;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku 20014, Finland
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- Rotter, Jerome I. (author)
- Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA 90502 USA;Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Dept Med, Torrance, CA 90502 USA
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- Rudan, Igor (author)
- Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh EH8 9YL, Midlothian, Scotland
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- Samani, Nilesh J. (author)
- Univ Leicester, Dept Cardiovasc Sci, Leicester LE1 7RH, Leics, England;NIHR Leicester Biomed Res Ctr, Leicester LE3 9QD, Leics, England
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- Schlessinger, David (author)
- NIA, Lab Genet & Gen, NIH, Baltimore, MD 20892 USA
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- Aldana, Claudia T. Silva (author)
- Erasmus Univ, Med Ctr, Dept Epidemiol, Genet Epidemiol Unit, NL-3015 GD Rotterdam, Netherlands;Univ Rosario, Sch Med & Hlth Sci, Ctr Res Genet & Genom CIGGUR, GENIUROS Res Grp,Inst Translat Med IMT, Cl 12c 6-25, Bogota, Colombia
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- Sinner, Moritz F. (author)
- Hosp Ludwig Maximilians Univ LMU Munich, Dept Internal Med Cardiol 1, D-81377 Munich, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80802 Munich, Germany
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- Smith, Jonathan D. (author)
- Cleveland Clin, Heart & Vasc Inst, Dept Cardiovasc Med, Cleveland, OH 44195 USA;Cleveland Clin, Lerner Res Inst, Dept Cellular & Mol Med Biol, Cleveland, OH 44195 USA
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- Snieder, Harold (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9713GZ Groningen, Netherlands
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- Soliman, Elsayed Z. (author)
- Wake Forest Sch Med, Epidemiol Cardiol Res Ctr, Winston Salem, NC 27101 USA
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- Spector, Timothy D. (author)
- Kings Coll London, St Thomas Hosp, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
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- Stott, David J. (author)
- Univ Glasgow, Coll Med Vet & Life Sci, Inst Cardiovasc & Med Sci, Glasgow G12 8TA, Lanark, Scotland
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- Strauch, Konstantin (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, D-85764 Neuherberg, Germany;Ludwig Maximilians Univ Munchen, Fac Med, IBE, Chair Genet Epidemiol, D-81377 Munich, Germany
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- Tarasov, Kirill V. (author)
- NIA, Lab Cardiovasc Sci, NIH, Bethesda, MD 20892 USA
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- Thorsteinsdottir, Unnur (author)
- DeCODE Genet Amgen Inc, IS-101 Reykjavik, Iceland;Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland
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- Uitterlinden, Andre G. (author)
- Erasmus MC, Dept Internal Med, NL-3015 GD Rotterdam, Netherlands
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- Van Wagoner, David R. (author)
- Cleveland Clin, Heart & Vasc Inst, Dept Cardiovasc Med, Cleveland, OH 44195 USA
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- Voelker, Uwe (author)
- DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany;Univ Med Greifswald, Interfac Inst Genet & Funct Genom, D-17489 Greifswald, Germany
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- Voelzke, Henry (author)
- Univ Med Greifswald, Inst Community Med, D-17489 Greifswald, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany
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- Waldenberger, Melanie (author)
- DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80802 Munich, Germany;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, D-85764 Neuherberg, Germany;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, D-85764 Neuherberg, Germany
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- Westra, Harm Jan (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-7913GZ Groningen, Netherlands
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- Wild, Philipp S. (author)
- DZHK German Ctr Cardiovasc Res, Partner Site Rhine Main, D-55131 Mainz, Germany;Johannes Gutenberg Univ Mainz, Univ Med Ctr, CTVB, D-55131 Mainz, Germany;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Cardiol, Prevent Cardiol & Prevent Med, D-55131 Mainz, Germany;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, D-55131 Mainz, Germany
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- Zeller, Tanja (author)
- Univ Heart Ctr Hamburg Eppendorf, Dept Gen & Intervent Cardiol, D-20251 Hamburg, Germany;DZHK German Ctr Cardiovasc Res, Partner Site, Hamburg, Germany
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- Alonso, Alvaro (author)
- Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA
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- Avery, Christy L. (author)
- Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27514 USA;Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27514 USA
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- Bandinelli, Stefania (author)
- ASF, Geriatr Unit, I-50122 Florence, Italy
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- Benjamin, Emelia J. (author)
- Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands
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- Cucca, Francesco (author)
- CNR, Ist Ric Genet & Biomed, I-00185 Cagliari, Italy
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- Doerr, Marcus (author)
- DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany;Univ Med Greifswald, Dept Internal Med B, D-17489 Greifswald, Germany
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- Ferrucci, Luigi (author)
- NIA, Translat Gerontol Branch, Bethesda, MD 20892 USA
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- Gasparini, Paolo (author)
- IRCCS Burlo Garofolo, Inst Maternal & Child Health, I-34137 Trieste, Italy;Univ Trieste, Dept Med Sci, I-34127 Trieste, Italy
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- Gudnason, Vilmundur (author)
- Iceland Heart Assoc, IS-201 Kopavogur, Iceland;Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland
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- Hayward, Caroline (author)
- Univ Edinburgh, Inst Genet & Mol Med, Med Res Council, Human Genet Unit, Edinburgh EH8 9YL, Midlothian, Scotland
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- Heckbert, Susan R. (author)
- Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
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- Hicks, Andrew A. (author)
- Univ Lubeck, Inst Biomed, Affiliated Inst, Eurac Res, I-39100 Bolzano, Italy
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- Jukema, J. Wouter (author)
- Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands;Leiden Univ, Med Ctr, Einthoven Lab Expt Vasc Med, NL-2300 RC Leiden, Netherlands;Interuniv Cardiol Inst Netherlands, NL-3511EP Utrecht, Netherlands
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- Kaeaeb, Stefan (author)
- Hosp Ludwig Maximilians Univ LMU Munich, Dept Internal Med Cardiol 1, D-81377 Munich, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80802 Munich, Germany
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- Lehtimaki, Terho (author)
- Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland;Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere 33014, Finland
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- Liu, Yongmei (author)
- Wake Forest Univ, Div Publ Hlth Sci, Dept Epidemiol & Prevent, Winston Salem, NC 27101 USA
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- Munroe, Patricia B. (author)
- Queen Mary Univ London, William Harvey Res Inst, Clin Pharmacol, London E1 4NS, England;Barts Hlth NHS Trust & Queen Mary Univ London, NIHR Biomed Res Ctr, London E1 4NS, England
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- Parsa, Afshin (author)
- Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA;Baltimore VA Med Ctr, Baltimore, MD 21201 USA
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- Polasek, Ozren (author)
- Univ Split, Fac Med, Split 21000, Croatia;Psychiat Hosp Sveti Ivan, Zagreb 10000, Croatia;Gen Info Ltd, Zagreb 10000, Croatia
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- Psaty, Bruce M. (author)
- Univ Washington, Cardiovasc Hlth Res Unit, Dept Med, Seattle, WA 98195 USA;Univ Washington, Cardiovasc Hlth Res Unit, Dept Epidemiol & Hlth Serv, Seattle, WA 98195 USA;Kaiser Permanente Washington Hlth Res Inst, Seattle, WA 98101 USA
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- Roden, Dan M. (author)
- Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland;Vanderbilt Univ, Med Pharmacol & Biomed Informat, Nashville, TN 37235 USA
-
- Schnabel, Renate B. (author)
- Univ Heart Ctr Hamburg Eppendorf, Dept Gen & Intervent Cardiol, D-20251 Hamburg, Germany;DZHK German Ctr Cardiovasc Res, Partner Site, Hamburg, Germany
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- Sinagra, Gianfranco (author)
- Osped Riuniti, Cardiovasc Dept, I-34124 Trieste, Italy;Univ Trieste, I-34124 Trieste, Italy
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- Stefansson, Kari (author)
- DeCODE Genet Amgen Inc, IS-101 Reykjavik, Iceland;Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland
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- Stricker, Bruno H. (author)
- Erasmus MC, Dept Epidemiol, NL-3015 GD Rotterdam, Netherlands;Erasmus MC, Dept Internal Med, NL-3015 GD Rotterdam, Netherlands;Inspectorate Hlth Care, NL-2511VX The Hague, Netherlands
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- van der Harst, Pim (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-7913GZ Groningen, Netherlands;Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-7913GZ Groningen, Netherlands;Netherlands Heart Inst, ICIN, Durrer Ctr Cardiogenet Res, NL-3511EP Utrecht, Netherlands
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- van Duijn, Cornelia M. (author)
- Erasmus Univ, Med Ctr, Dept Epidemiol, Genet Epidemiol Unit, NL-3015 GD Rotterdam, Netherlands
-
- Wilson, James F. (author)
- Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh EH8 9YL, Midlothian, Scotland
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- Gharib, Sina A. (author)
- Univ Washington, Div Pulm Crit Care & Sleep Med, Computat Med Core Ctr Lung Biol, Cardiovasc Hlth Res Unit,Dept Med, Seattle, WA 98195 USA
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- de Bakker, Paul I. W. (author)
- Univ Med Ctr Utrecht, Ctr Mol Med, Dept Genet, NL-3584 CX Utrecht, Netherlands;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, NL-3584 CX Utrecht, Netherlands
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- Isaacs, Aaron (author)
- CARIM Sch Cardiovasc Dis, NL-6229ER Maastricht, Netherlands;Maastricht Univ, Ctr Syst Biol MaCSBio, NL-6229ER Maastricht, Netherlands;Maastricht Univ, Dept Biochem, NL-6229ER Maastricht, Netherlands
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- Arking, Dan E. (author)
- Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21287 USA
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- Sotoodehnia, Nona (author)
- Univ Washington, Cardiovasc Hlth Res Unit, Div Cardiol, Dept Med, Seattle, WA 98101 USA;Univ Washington, Cardiovasc Hlth Res Unit, Div Cardiol, Dept Epidemiol, Seattle, WA 98101 USA
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(creator_code:org_t)
- 2018-07-25
- 2018
- English.
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In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 9
- Related links:
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Abstract
Subject headings
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- Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genomewide association study of over 92,000 European-descent individuals identifies 44 PR interval loci (34 novel). Examination of these loci reveals known and previously not-yet-reported biological processes involved in cardiac atrial electrical activity. Genes in these loci are overrepresented in cardiac disease processes including heart block and atrial fibrillation. Variants in over half of the 44 loci were associated with atrial or blood transcript expression levels, or were in high linkage disequilibrium with missense variants. Six additional loci were identified either by meta-analysis of similar to 105,000 African and European-descent individuals and/or by pleiotropic analyses combining PR interval with heart rate, QRS interval, and atrial fibrillation. These findings implicate developmental pathways, and identify transcription factors, ionchannel genes, and cell-junction/cell-signaling proteins in atrio-ventricular conduction, identifying potential targets for drug development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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Uppsala University