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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004574naa a2200553 4500
001oai:DiVA.org:uu-442508
003SwePub
008210517s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:146406776
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4425082 URI
024a https://doi.org/10.3389/fnbeh.2021.6672442 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1464067762 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Titulaer, Joepu Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Karolinska Inst, Sect Neuropsychopharmacol, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut0 (Swepub:uu)joeti107
2451 0a The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory
264 c 2021-04-13
264 1b Frontiers Media S.A.c 2021
338 a electronic2 rdacarrier
500 a De två sista författarna delar sistaförfattarskapet.
520 a Dopaminergic neurons originating from the ventral tegmental area (VTA) and the locus coeruleus are innervating the ventral hippocampus and are thought to play an essential role for efficient cognitive function. Moreover, these VTA projections are hypothesized to be part of a functional loop, in which dopamine regulates memory storage. It is hypothesized that when a novel stimulus is encountered and recognized as novel, increased dopamine activity in the hippocampus induces long-term potentiation and long-term storage of memories. We here demonstrate the importance of increased release of dopamine and norepinephrinein the rat ventral hippocampus on recognition memory, using microdialysis combined to a modified novel object recognition test. We found that presenting rats to a novel object significantly increased dopamine and norepinephrine output in the ventral hippocampus. Two hours after introducing the first object, a second object (either novel or familiar) was placed in the same position as the first object. Presenting the animals to a second novel object significantly increased dopamine and norepinephrine release in the ventral hippocampus, compared to a familiar object. In conclusion, this study suggests that dopamine and norepinephrine output in the ventral hippocampus has a crucial role in recognition memory and signals novelty.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a ventral hippocampus
653 a hippocampus
653 a dopamine
653 a norepinephrine
653 a microdialysis
653 a novelty
653 a novel object recognition (NOR)
653 a recognition memory
700a Björkholm, Carlu Karolinska Inst, Sect Neuropsychopharmacol, Dept Physiol & Pharmacol, Stockholm, Sweden.;Janssen Cilag AB, Solna, Sweden.4 aut
700a Feltmann, Kristinu Karolinska Institutet4 aut
700a Malmlöf, Torunu Karolinska Inst, Sect Neuropsychopharmacol, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut
700a Mishra, Deveshu Karolinska Inst, Sect Neuropsychopharmacol, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut
700a Bengtsson Gonzales, Carolinau Karolinska Inst, Sect Neuropsychopharmacol, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut
700a Schilström, Björnu Karolinska Inst, Sect Neuropsychopharmacol, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut
700a Konradsson-Geuken, Åsau Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Karolinska Inst, Sect Neuropsychopharmacol, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut0 (Swepub:uu)asako336
710a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org
773t Frontiers in Behavioral Neuroscienced : Frontiers Media S.A.g 15q 15x 1662-5153
856u https://doi.org/10.3389/fnbeh.2021.667244y Fulltext
856u https://uu.diva-portal.org/smash/get/diva2:1554787/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856u https://www.frontiersin.org/articles/10.3389/fnbeh.2021.667244/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-442508
8564 8u https://doi.org/10.3389/fnbeh.2021.667244
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:146406776

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