Sökning: WFRF:(Malmlöf Torun) > The Importance of V...
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000 | 04574naa a2200553 4500 | |
001 | oai:DiVA.org:uu-442508 | |
003 | SwePub | |
008 | 210517s2021 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:146406776 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4425082 URI |
024 | 7 | a https://doi.org/10.3389/fnbeh.2021.6672442 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1464067762 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Titulaer, Joepu Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Karolinska Inst, Sect Neuropsychopharmacol, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut0 (Swepub:uu)joeti107 |
245 | 1 0 | a The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory |
264 | c 2021-04-13 | |
264 | 1 | b Frontiers Media S.A.c 2021 |
338 | a electronic2 rdacarrier | |
500 | a De två sista författarna delar sistaförfattarskapet. | |
520 | a Dopaminergic neurons originating from the ventral tegmental area (VTA) and the locus coeruleus are innervating the ventral hippocampus and are thought to play an essential role for efficient cognitive function. Moreover, these VTA projections are hypothesized to be part of a functional loop, in which dopamine regulates memory storage. It is hypothesized that when a novel stimulus is encountered and recognized as novel, increased dopamine activity in the hippocampus induces long-term potentiation and long-term storage of memories. We here demonstrate the importance of increased release of dopamine and norepinephrinein the rat ventral hippocampus on recognition memory, using microdialysis combined to a modified novel object recognition test. We found that presenting rats to a novel object significantly increased dopamine and norepinephrine output in the ventral hippocampus. Two hours after introducing the first object, a second object (either novel or familiar) was placed in the same position as the first object. Presenting the animals to a second novel object significantly increased dopamine and norepinephrine release in the ventral hippocampus, compared to a familiar object. In conclusion, this study suggests that dopamine and norepinephrine output in the ventral hippocampus has a crucial role in recognition memory and signals novelty. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a ventral hippocampus | |
653 | a hippocampus | |
653 | a dopamine | |
653 | a norepinephrine | |
653 | a microdialysis | |
653 | a novelty | |
653 | a novel object recognition (NOR) | |
653 | a recognition memory | |
700 | 1 | a Björkholm, Carlu Karolinska Inst, Sect Neuropsychopharmacol, Dept Physiol & Pharmacol, Stockholm, Sweden.;Janssen Cilag AB, Solna, Sweden.4 aut |
700 | 1 | a Feltmann, Kristinu Karolinska Institutet4 aut |
700 | 1 | a Malmlöf, Torunu Karolinska Inst, Sect Neuropsychopharmacol, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut |
700 | 1 | a Mishra, Deveshu Karolinska Inst, Sect Neuropsychopharmacol, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut |
700 | 1 | a Bengtsson Gonzales, Carolinau Karolinska Inst, Sect Neuropsychopharmacol, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut |
700 | 1 | a Schilström, Björnu Karolinska Inst, Sect Neuropsychopharmacol, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut |
700 | 1 | a Konradsson-Geuken, Åsau Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Karolinska Inst, Sect Neuropsychopharmacol, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut0 (Swepub:uu)asako336 |
710 | 2 | a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org |
773 | 0 | t Frontiers in Behavioral Neuroscienced : Frontiers Media S.A.g 15q 15x 1662-5153 |
856 | 4 | u https://doi.org/10.3389/fnbeh.2021.667244y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1554787/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.frontiersin.org/articles/10.3389/fnbeh.2021.667244/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-442508 |
856 | 4 8 | u https://doi.org/10.3389/fnbeh.2021.667244 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146406776 |
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