SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(McCabe D.)
 

Sökning: WFRF:(McCabe D.) > (2010-2014) > Metabolite Profilin...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004404naa a2200541 4500
001oai:lup.lub.lu.se:6bf893af-4bcf-4dc5-a030-013063a5c050
003SwePub
008160401s2012 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/31358102 URI
0247 a https://doi.org/10.1161/CIRCULATIONAHA.111.0678272 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Cheng, Susan4 aut
2451 0a Metabolite Profiling Identifies Pathways Associated With Metabolic Risk in Humans
264 1c 2012
520 a Background-Although metabolic risk factors are known to cluster in individuals who are prone to developing diabetes mellitus and cardiovascular disease, the underlying biological mechanisms remain poorly understood. Methods and Results-To identify pathways associated with cardiometabolic risk, we used liquid chromatography/mass spectrometry to determine the plasma concentrations of 45 distinct metabolites and to examine their relation to cardiometabolic risk in the Framingham Heart Study (FHS; n=1015) and the Malmo Diet and Cancer Study (MDC; n=746). We then interrogated significant findings in experimental models of cardiovascular and metabolic disease. We observed that metabolic risk factors (obesity, insulin resistance, high blood pressure, and dyslipidemia) were associated with multiple metabolites, including branched-chain amino acids, other hydrophobic amino acids, tryptophan breakdown products, and nucleotide metabolites. We observed strong associations of insulin resistance traits with glutamine (standardized regression coefficients, -0.04 to -0.22 per 1-SD change in log-glutamine; P<0.001), glutamate (0.05 to 0.14; P<0.001), and the glutamine-toglutamate ratio (-0.05 to -0.20; P<0.001) in the discovery sample (FHS); similar associations were observed in the replication sample (MDC). High glutamine-to-glutamate ratio was associated with lower risk of incident diabetes mellitus in FHS (odds ratio, 0.79; adjusted P=0.03) but not in MDC. In experimental models, administration of glutamine in mice led to both increased glucose tolerance (P=0.01) and decreased blood pressure (P=0.05). Conclusions-Biochemical profiling identified circulating metabolites not previously associated with metabolic traits. Experimentally interrogating one of these pathways demonstrated that excess glutamine relative to glutamate, resulting from exogenous administration, is associated with reduced metabolic risk in mice. (Circulation. 2012;125:2222-2231.)
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a epidemiology
653 a metabolic syndrome
653 a metabolomics
653 a risk factors
7001 a Rhee, Eugene P.4 aut
7001 a Larson, Martin G.4 aut
7001 a Lewis, Gregory D.4 aut
7001 a McCabe, Elizabeth L.4 aut
7001 a Shen, Dongxiao4 aut
7001 a Palma, Melinda J.4 aut
7001 a Roberts, Lee D.4 aut
7001 a Dejam, Andre4 aut
7001 a Souza, Amanda L.4 aut
7001 a Deik, Amy A.4 aut
7001 a Magnusson, Martinu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)medf-mma
7001 a Fox, Caroline S.4 aut
7001 a O'Donnell, Christopher J.4 aut
7001 a Vasan, Ramachandran S.4 aut
7001 a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
7001 a Clish, Clary B.4 aut
7001 a Gerszten, Robert E.4 aut
7001 a Wang, Thomas J.4 aut
7102 a Kardiovaskulär forskning - hypertonib Forskargrupper vid Lunds universitet4 org
7730 t Circulationg 125:18, s. 132-2222q 125:18<132-2222x 1524-4539
8564 u http://dx.doi.org/10.1161/CIRCULATIONAHA.111.067827y FULLTEXT
8564 8u https://lup.lub.lu.se/record/3135810
8564 8u https://doi.org/10.1161/CIRCULATIONAHA.111.067827

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy