In vivo characterization of the mechanics of human uterine cervices

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Fältnamn	Indikatorer	Metadata
000		03234naa a2200457 4500
001		oai:DiVA.org:kth-155647
003		SwePub
008		141107s2007 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1556472 URI
024	7	a https://doi.org/10.1196/annals.1389.0042 DOI
040		a (SwePub)kth
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a kon2 swepub-publicationtype
100	1	a Bauer, M.4 aut
245	1 0	a In vivo characterization of the mechanics of human uterine cervices
264		c 2007-02-15
264	1	b Blackwell Publishing,c 2007
338		a print2 rdacarrier
500		a QC 201411
520		a The uterine cervix has to provide mechanical resistance to ensure a normal development of the fetus. This is guaranteed by the composition of its extracellular matrix, which functions as a fiber-reinforced composite. At term a complex remodeling process allows the cervical canal to open for birth. This remodeling is achieved by changes in the quality and quantity of collagen fibers and ground substance and their interplay, which influences the biomechanical behavior of the cervix but also contributes to pathologic conditions such as cervical incompetence (CI). We start by reviewing the anatomy and histological composition of the human cervix, and discuss its physiologic function and pathologic condition in pregnancy including biomechanical aspects. Established diagnostic methods on the cervix (palpation, endovaginal ultrasound) used in clinics as well as methods for assessment of cervical consistency (light-induced fluorescence, electrical current, and impedance) are discussed. We show the first clinical application of an aspiration device, which allows in vivo testing of the biomechanical properties of the cervix with the aim to establish the physiological biomechanical changes throughout gestation and to detect pregnant women at risk for CI. In a pilot study on nonpregnant cervices before and after hysterectomy we found no considerable difference in the biomechanical response between in vivo and ex vivo. An outlook on further clinical applications during pregnancy is presented.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Annan medicin och hälsovetenskap0 (SwePub)3052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Other Medical and Health Sciences0 (SwePub)3052 hsv//eng
653		a Aspiration device
653		a Biomechanical properties
653		a In vivo experiment
653		a Remodeling in pregnancy
653		a Uterine cervix
700	1	a Mazza, E.4 aut
700	1	a Nava, A.4 aut
700	1	a Zeck, W.4 aut
700	1	a Eder, M.4 aut
700	1	a Bajka, M.4 aut
700	1	a Cacho, F.4 aut
700	1	a Lang, U.4 aut
700	1	a Holzapfel, Gerhard A.u KTH,Hållfasthetslära (Inst.),Graz University of Technology, Austria4 aut0 (Swepub:kth)u1esp3uu
710	2	a KTHb Hållfasthetslära (Inst.)4 org
773	0	t Reproductive Biomechanicsd : Blackwell Publishingg , s. 186-202q <186-202z 1573316733z 9781573316736
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-155647
856	4 8	u https://doi.org/10.1196/annals.1389.004

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Av författaren/redakt...: Bauer, M.; Mazza, E.; Nava, A.; Zeck, W.; Eder, M.; Bajka, M.; visa fler...; Cacho, F.; Lang, U.; Holzapfel, Gerha ...; visa färre...

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