Sökning: WFRF:(Nef Holger) > Novel rat model rev...
Fältnamn | Indikatorer | Metadata |
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000 | 03584naa a2200373 4500 | |
001 | oai:gup.ub.gu.se/173544 | |
003 | SwePub | |
008 | 240528s2013 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/1735442 URI |
024 | 7 | a https://doi.org/10.1016/j.ijcard.2012.12.0922 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Shao, Yangzhen,d 1981u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xshaya |
245 | 1 0 | a Novel rat model reveals important roles of β-adrenoreceptors in stress-induced cardiomyopathy. |
264 | 1 | b Elsevier BV,c 2013 |
520 | a BACKGROUND: Stress-induced cardiomyopathy (SIC), also known as Takotsubo cardiomyopathy, is an acute cardiac syndrome with substantial morbidity and mortality. The unique hallmark of SIC is extensive ventricular akinesia involving apical segments with preserved function in basal segments. Adrenergic overstimulation plays an important role in initiating SIC but the pathophysiological pathways and receptors involved are unknown. METHODS: Sprague Dawley rats (~300g) were injected with a single dose of the β-adrenergic agonist isoprenaline (ISO, i.p.) and echocardiography was used to study cardiac function. The akinetic part of the left ventricle was biopsied in six SIC patients. Amount of intracellular lipid and glycogen as well as degree of permanent cardiac damage were assessed by histology. RESULTS: In rats, ISO at doses ≥50mg/kg induced severe SIC-like regional akinesia that completely resolved within seven days. Intracellular lipid content was higher in akinetic, but not in normokinetic myocardium in both SIC patients and rats. β2-receptor blockade or Gi-pathway inhibition was associated with less widespread akinesia and low lipid accumulation but significantly increased acute mortality. CONCLUSIONS: We provide a novel rat model of SIC that supports the hypothesis of circulating catecholamines as initiators of SIC. We propose that the β-adrenoreceptor pathway is important in the setting of severe catecholamine overstimulation and that perturbations of cardiac metabolism occur in SIC. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Redfors, Björnu Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xredbj |
700 | 1 | a Scharin Täng, Margareta,d 1962u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xscham |
700 | 1 | a Möllmann, Helge4 aut |
700 | 1 | a Troidl, Christian4 aut |
700 | 1 | a Szardien, Sebastian4 aut |
700 | 1 | a Hamm, Christian4 aut |
700 | 1 | a Nef, Holger4 aut |
700 | 1 | a Borén, Jan,d 1963u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xborej |
700 | 1 | a Omerovic, Elmir,d 1968u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xomeel |
710 | 2 | a Göteborgs universitetb Wallenberglaboratoriet4 org |
773 | 0 | t International journal of cardiologyd : Elsevier BVg 168:3, s. 1943-1950q 168:3<1943-1950x 1874-1754x 0167-5273 |
856 | 4 8 | u https://gup.ub.gu.se/publication/173544 |
856 | 4 8 | u https://doi.org/10.1016/j.ijcard.2012.12.092 |
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