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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004523nam a2200385 4500
001oai:DiVA.org:liu-85000
003SwePub
008121030| | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-850002 URI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a ovr2 swepub-publicationtype
1001 a Ferdousi, Hosne Arau Linköpings universitet,Pediatrik,Hälsouniversitetet4 aut0 (Swepub:liu)hosfe33
2451 0a Clinical characteristics of school children with birch and/or grass pollen hay-fever (The PAT-Study)
338 a print2 rdacarrier
520 a Background: To describe the clinical characteristics of school children with hay-fever based on baseline data from the PAT-Study.Material: Two hundred and five children, 6-15 years, mean 10.7 years, with birch and or grass pollen hay-fever, without known asthma were recruited by six pediatric allergy centers in Northern and Central Europe.Methods: Bronchial hyperresponsiveness (BHR) to methacholine tested by methacholine bronchial provocation test (MBPT) expressed in PC20 was registered during the birch and grass pollen seasons. During the winter symptoms of conjunctivitis, rhinitis and asthma were graded by visual analogue scale (VAS), conjunctival provocation test with birch and or timothy pollen extracts, skin tests with a panel of allergen extracts and MBPT were done and a questionnaire was filled in. Differences of p <0.01 level or less were considered significant.Results: Despite the children were included because of seasonal hay-fever without known asthma, 42/205 children (21 %) got doctor diagnosed asthma (DDA) after the first season. During the three seasons, between 60 and 73 % of the children had a PC20 to methacholine ≤ 8 mg/ml, about 30 % to ≤ 2 mg/ml and 7-10% even to ≤ 0.5 mg/ml. Most children had both rhinitis and conjunctivitis. Furthermore, 119/201 children (59%) were regularly exposed to furred animals.There was an association between DDA and the sum of VAS for asthma during the pollen seasons.The BHR was significantly more pronounced in those with than those without DDA during all three seasons: Using the three cut offs, the difference was most pronounced during the winter season but reached also significance using the cut off limit 0.5 mg/ml during the birch pollen season.Doctor diagnosed asthma correlated to PC20 during the seasons for most of the cut off limits for PC20 and in general there was an association in PC20 between the seasons independent of cut off limits.Furthermore, DDA, but not BHR, correlated to exposure to traffic and there was an association between exposure to traffic and industrial pollution, but not to ETS or duration of breastfeeding.Conclusion: The most striking feature of school children with uncomplicated hay-fever was the high frequency of DDA and BHR, most pronounced during the winter, the high frequency of exposure to living animals and sensitization to indoor allergens. Hay-fever is a generalized disease. Even without obvious asthma, BHR is common and most children have symptoms from both the eyes and the airways. Diagnosis of asthma in children with hay-fever and early anti-inflammatory treatment may improve the prognosis.
653 a MEDICINE
653 a MEDICIN
7001 a Halken, Susanneu Central Hospital, Sønderborg, Denmark4 aut
7001 a Høst, Arneu University Hospital, Odense, Denmark4 aut
7001 a Jacobsen, Larsu ALK-Albelló, Hørsholm, Denmark4 aut
7001 a Løwenstein, Henningu ALK-Albelló, Hørsholm, Denmark4 aut
7001 a Koivikko, Anttiu University Hospital, Turku, Finland4 aut
7001 a Möller, Christianu University Hospital, Umeå, Sweden4 aut
7001 a Niggemann, Bodou University Children's Hospital Charité of Humbolt-University, Berlin, Germany4 aut
7001 a Norberg, Lene Annetteu University Hospital, Odense, Denmark4 aut
7001 a Urbanek, Radvanu University Hospital, Vienna, Austria4 aut
7001 a Koller, Dieter Y.u University Hospital, Vienna, Austria4 aut
7001 a Wahn, Ulrichu University Children's Hospital Charité of Humbolt-University, Berlin, Germany4 aut
7001 a Valovirta, Erkkau University Hospital, Turku, Finland4 aut
7001 a Dreborg, Stenu Linköpings universitet,Hälsouniversitetet4 aut
7102 a Linköpings universitetb Pediatrik4 org
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-85000

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