WFRF:(Nilsson Lena Docent 1956 )
Sökning: WFRF:(Nilsson Lena Docent 1956 ) > Signatures in in vi...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03551naa a2200433 4500 | |
| 001 | oai:DiVA.org:uu-502504 | |
| 003 | SwePub | |
| 008 | 230529s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5025042 URI |
| 024 | 7 | a https://doi.org/10.1186/s12866-023-02859-02 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kask, Lenau Uppsala universitet,Klinisk mikrobiologi4 aut0 (Swepub:uu)lenka879 |
| 245 | 1 0 | a Signatures in in vitro infection of NSC-34 mouse neurons and their cell nucleus with Rickettsia helvetica |
| 264 | 1 | b BioMed Central (BMC),c 2023 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Background: Rickettsia helvetica, a spotted fever rickettsia, is transmitted to humans via ticks in Europe, North Africa, and Asia. The central nervous system is a crucial target for rickettsial diseases, which has been reported for 12 of the 31 species, of which R. helvetica is one. This study aimed, in an experimental model, to identify characteristics of R. helvetica infection in a mouse neuronal cell line, NSC-34.Results: NSC-34, a fusion cell line of mouse motor spinal cord neurons and neuroblastoma cells, was used as a model. Propagation of R. helvetica in neurons was confirmed. Short actin tails were shown at the polar end of the bacteria, which makes it likely that they can move intracellularly, and even spread between cells. Another protein, Sca4, which with the cell adhesion protein vinculin enables the passage of the cell membrane, was expressed during infection. No significant increase in TNF alpha levels was seen in the infected neurons, which is of interest because TNF alpha protects the host cell from infection-induced apoptotic death which is crucial for host cell survival. The bacteria were also shown to invade and grow in the cell nucleus of the neuron.Conclusions: The findings suggest that a R. helvetica infection may be harmful to NSC-34 neurons under these in vitro conditions, but the full effects of the infection on the cell need to be studied further, also on human neurons, to also understand the possible significance of this infection in relation to pathogenetic mechanisms. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
| 653 | a Rickettsia helvetica | |
| 653 | a Neuron cell line | |
| 653 | a NSC-34 | |
| 653 | a Actin tail | |
| 653 | a TEM | |
| 653 | a qPCR | |
| 653 | a Western blot | |
| 653 | a Immunofluorescence | |
| 700 | 1 | a Påhlson, Carl,d 1956-u Uppsala universitet,Klinisk mikrobiologi4 aut0 (Swepub:uu)carlpahl |
| 700 | 1 | a Staxäng, Karinu Uppsala universitet,Institutionen för immunologi, genetik och patologi,BioVis4 aut0 (Swepub:uu)karst215 |
| 700 | 1 | a Nilsson, Kenneth,c Docent,d 1953-u Uppsala universitet,Klinisk mikrobiologi,Infektionsmedicin4 aut0 (Swepub:uu)kenil103 |
| 710 | 2 | a Uppsala universitetb Klinisk mikrobiologi4 org |
| 773 | 0 | t BMC Microbiologyd : BioMed Central (BMC)g 23q 23x 1471-2180 |
| 856 | 4 | u https://doi.org/10.1186/s12866-023-02859-0y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1760074/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-502504 |
| 856 | 4 8 | u https://doi.org/10.1186/s12866-023-02859-0 |
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