WFRF:(Nobin Rebecca)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06325naa a2200565 4500 | |
| 001 | oai:DiVA.org:lnu-106628 | |
| 003 | SwePub | |
| 008 | 210827s2021 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:liu-180309 | |
| 009 | oai:lup.lub.lu.se:4f7b010c-8427-4a6f-9a8a-60c9280c186b | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-1066282 URI |
| 024 | 7 | a https://doi.org/10.1371/journal.pone.02560932 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1803092 URI |
| 024 | 7 | a https://lup.lub.lu.se/record/4f7b010c-8427-4a6f-9a8a-60c9280c186b2 URI |
| 040 | a (SwePub)lnud (SwePub)liud (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Nordqvist, Ola,d 1979-u Linnaeus University,Linnéuniversitetet,Institutionen för medicin och optometri (MEO),Hållbar hälsa,Region Kalmar County, Sweden,eHälsoinstitutet;eHealth Institute,Linnaeus Univ, Sweden; Pharmaceut Dept, Sweden4 aut0 (Swepub:lnu)olnoaa |
| 245 | 1 0 | a A novel index to assess low energy fracture risks in patients prescribed antiepileptic drugs |
| 264 | c 2021-08-26 | |
| 264 | 1 | a San Francisco :b Public Library of Science,c 2021 |
| 338 | a print2 rdacarrier | |
| 520 | a Objective: To develop an index assessing the risks of low energy fractures (LEF) in patients prescribed antiepileptic drugs (AED) by exploring five previously suggested risk factors; age, gender, AED-type, epilepsy diagnosis and BMI.Methods: In a population-based retrospective open cohort study we used real world data from the Electronic Health Register (EHR) in Region Kalmar County, Sweden. 23 209 patients prescribed AEDs at any time from January 2008 to November 2018 and 23 281 matching controls were followed from first registration in the EHR until the first documented LEF, disenrollment (or death) or until the end of the study period, whichever came first. Risks of LEF measured as hazard rate ratios in relation to the suggested risk factors and in comparison to matched controls were analyzed using Cox regression. The index was developed using a linear combination of the statistically significant variables multiplied by the corresponding regression coefficients.Results: Data from 23 209 patients prescribed AEDs and 2084 documented LEFs during a follow-up time of more than 10 years resulted in the Kalmar Epilepsy Fracture Risk Index (KEFRI). KEFRI = Age-category x (1.18) + Gender x (-0.51) + AED-type x (0.29) + Epilepsy diagnosis-category x (0.31) + BMI-category x (-0.35). All five previously suggested risk factors were confirmed. Women aged 75 years and older treated with an inducing AED against epilepsy and BMIs of 25 kg/m2 or below had 48 times higher LEF rates compared to men aged 50 years or younger, treated with a non-inducing AED for a condition other than epilepsy and BMIs above 25 kg/m2.Conclusion: The KEFRI is the first weighted multifactorial assessment tool estimating risks of LEF in patients prescribed AEDs and could serve as a feasible guide within clinical practice. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Allmänmedicin0 (SwePub)302242 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex General Practice0 (SwePub)302242 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a Medicin | |
| 653 | a Medicine | |
| 700 | 1 | a Björneld, Olofu Linnaeus University,Linnéuniversitetet,Institutionen för datavetenskap och medieteknik (DM),Region Kalmar County, Sweden,eHälsoinstitutet;eHealth Institute;DISA-IDP,Linnaeus Univ, Sweden; Linnaeus Univ, Sweden; Business Intelligence, Sweden4 aut0 (Swepub:lnu)olbjaa |
| 700 | 1 | a Brudin, Lars,d 1946-u Linköping University,Linköpings universitet,Medicinska fakulteten,Avdelningen för diagnostik och specialistmedicin,Dept Clin Physiol, Sweden,Region Kalmar County4 aut0 (Swepub:liu)larbr27 |
| 700 | 1 | a Wanby, Päru Linnaeus University,Linköping University,Linköpings universitet,Linnéuniversitetet,Institutionen för medicin och optometri (MEO),University of Linköping, Sweden;Region Kalmar County, Sweden,eHälsoinstitutet;eHealth Institute,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Linnaeus Univ, Sweden; Dept Internal Med, Sweden4 aut0 (Swepub:liu)parwa75 |
| 700 | 1 | a Nobin, Rebeccau Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Region Kalmar County4 aut0 (Swepub:lu)re2415no |
| 700 | 1 | a Carlsson, Martinu Linnaeus University,Linnéuniversitetet,Institutionen för medicin och optometri (MEO),Region Kalmar County, Sweden,eHälsoinstitutet;eHealth Institute,Linnaeus Univ, Sweden; Dept Clin Chem, Sweden4 aut0 (Swepub:lnu)macaaa |
| 710 | 2 | a Linnéuniversitetetb Institutionen för medicin och optometri (MEO)4 org |
| 773 | 0 | t PLOS ONEd San Francisco : Public Library of Scienceg 16:8q 16:8x 1932-6203 |
| 856 | 4 | u https://doi.org/10.1371/journal.pone.0256093y Fulltext |
| 856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0256093&type=printable |
| 856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1603279/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u http://dx.doi.org/10.1371/journal.pone.0256093x freey FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-106628 |
| 856 | 4 8 | u https://doi.org/10.1371/journal.pone.0256093 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-180309 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/4f7b010c-8427-4a6f-9a8a-60c9280c186b |
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