WFRF:(Normark Birgitta Henriques)
Search: WFRF:(Normark Birgitta Henriques) > (2005-2009) > A small-molecule in...
- 3 of 13
- Previous record
- Next record
- To hitlist
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04816naa a2200649 4500 | |
| 001 | oai:DiVA.org:umu-11787 | |
| 003 | SwePub | |
| 008 | 070612s2006 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-16691 | |
| 009 | oai:prod.swepub.kib.ki.se:1954028 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-117872 URI |
| 024 | 7 | a https://doi.org/10.1073/pnas.06064121032 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-166912 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19540282 URI |
| 040 | a (SwePub)umud (SwePub)ki | |
| 041 | a engb engb -1 | |
| 042 | 9 SwePub | |
| 072 | 7 | a vet2 swepub-contenttype |
| 072 | 7 | a kon2 swepub-publicationtype |
| 100 | 1 | a Muschiol, Sandrau Karolinska Institutet4 aut |
| 245 | 1 0 | a A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis |
| 264 | c 2006-09-26 | |
| 264 | 1 | a Washington :b Proceedings of the National Academy of Sciences,c 2006 |
| 338 | a print2 rdacarrier | |
| 520 | a The intracellular pathogen Chlamydia trachomatis possesses a type III secretion (TTS) system believed to deliver a series of effector proteins into the inclusion membrane (Inc-proteins) as well as into the host cytosol with perceived consequences for the pathogenicity of this common venereal pathogen. Recently, small molecules were shown to block the TTS system of Yersinia pseudotuberculosis. Here, we show that one of these compounds, INP0400, inhibits intracellular replication and infectivity of C. trachomatis at micromolar concentrations resulting in small inclusion bodies frequently containing only one or a few reticulate bodies (RBs). INP0400, at high concentration, given at the time of infection, partially blocked entry of elementary bodies into host cells. Early treatment inhibited the localization of the mammalian protein 14-3-3beta to the inclusions, indicative of absence of the early induced TTS effector IncG from the inclusion membrane. Treatment with INP0400 during chlamydial mid-cycle prevented secretion of the TTS effector IncA and homotypic vesicular fusions mediated by this protein. INP0400 given during the late phase resulted in the detachment of RBs from the inclusion membrane concomitant with an inhibition of RB to elementary body conversion causing a marked decrease in infectivity. | |
| 520 | a | |
| 653 | a 14-3-3 Proteins/metabolism | |
| 653 | a Anti-Bacterial Agents/chemistry/*pharmacology | |
| 653 | a Bacterial Proteins/*antagonists & inhibitors/metabolism | |
| 653 | a Cell Differentiation | |
| 653 | a Cell Membrane/metabolism | |
| 653 | a Chlamydia Infections/*drug therapy | |
| 653 | a Chlamydia trachomatis/cytology/*drug effects/*physiology/ultrastructure | |
| 653 | a Dose-Response Relationship; Drug | |
| 653 | a Inclusion Bodies/ultrastructure | |
| 653 | a Membrane Fusion | |
| 653 | a Phosphoproteins/metabolism | |
| 653 | a Protein Binding | |
| 653 | a Protein Transport | |
| 700 | 1 | a Bailey, Leslieu Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)leba0001 |
| 700 | 1 | a Gylfe, Åsa4 aut |
| 700 | 1 | a Sundin, Charlottau Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)4 aut0 (Swepub:umu)chasun99 |
| 700 | 1 | a Hultenby, Kjellu Karolinska Institutet4 aut |
| 700 | 1 | a Bergström, Svenu Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)svbe0001 |
| 700 | 1 | a Elofsson, Mikaelu Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)miel0001 |
| 700 | 1 | a Wolf-Watz, Hansu Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)4 aut0 (Swepub:umu)hawo0001 |
| 700 | 1 | a Normark, Staffanu Karolinska Institutet4 aut |
| 700 | 1 | a Henriques-Normark, Birgittau Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för molekylärbiologi (Medicinska fakulteten)4 org |
| 773 | 0 | t National Academy of Sciences, USAd Washington : Proceedings of the National Academy of Sciencesg , s. 14566-71q <14566-71 |
| 773 | 0 | t Proceedings of the National Academy of Sciencesd Washington : Proceedings of the National Academy of Sciencesg , s. 14566-71q <14566-71x 0027-8424x 1091-6490 |
| 856 | 4 | u http://www.pnas.org/content/103/39/14566.full.pdf |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16973741&dopt=Citation |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-11787 |
| 856 | 4 8 | u https://doi.org/10.1073/pnas.0606412103 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-16691 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1954028 |
Find in a library
- National Academy of Sciences, USA (Search for host publication in LIBRIS)
To the university's database
- 3 of 13
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Muschiol, Sandra
- Bailey, Leslie
- Gylfe, Åsa
- Sundin, Charlott ...
- Hultenby, Kjell
- Bergström, Sven
- show more...
- Elofsson, Mikael
- Wolf-Watz, Hans
- Normark, Staffan
- Henriques-Normar ...
- show less...
- Articles in the publication
- National Academy ...
- Proceedings of t ...
- By the university
- Umeå University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
