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Sökning: WFRF:(Ose A) > (2010-2014) > Endogenous androgen...

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FältnamnIndikatorerMetadata
00006336naa a2200961 4500
001oai:lup.lub.lu.se:8a4061fe-01bb-4af7-be44-fe815be80166
003SwePub
008160401s2014 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-97271
009oai:prod.swepub.kib.ki.se:130099714
0247 a https://lup.lub.lu.se/record/48719172 URI
0247 a https://doi.org/10.1002/ijc.290002 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-972712 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1300997142 URI
040 a (SwePub)lud (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Ose, Jennifer4 aut
2451 0a Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteristics in the European Prospective Investigation into Cancer and Nutrition
264 c 2014-06-16
264 1b Wiley,c 2014
520 a The role of endogenous androgens and sex hormone-binding globulin (SHBG) in ovarian carcinogenesis is poorly understood. Epithelial invasive ovarian cancer (EOC) is a heterogeneous disease and there are no prospective data on endogenous androgens and EOC risk by tumor characteristics (histology, grade, stage) or the dualistic model of ovarian carcinogenesis (i.e. type I vs. type II, leading to less or more aggressive tumors). We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort evaluating androgens and SHBG and invasive EOC risk by tumor characteristics. Female participants who provided a blood sample and were not using exogenous hormones at blood donation were eligible (n = 183,257). A total of 565 eligible women developed EOC; two controls (n = 1,097) were matched per case. We used multivariable conditional logistic regression models. We observed no association between androgens, SHBG and EOC overall. A doubling of androstenedione reduced risk of serous carcinomas by 21% (odds ratio (OR)log2=0.79, 95% confidence interval [CI]=[0.64-0.97]). Moreover, associations differed for low-grade and high-grade carcinomas, with positive associations for low-grade and inverse associations for high-grade carcinomas (e.g. androstenedione: low grade: ORlog2=1.99 [0.98-4.06]; high grade: ORlog2=0.75 [0.61-0.93], p(het)0.01), similar associations were observed for type I/II tumors. This is the first prospective study to evaluate androgens, SHBG and EOC risk by tumor characteristics and type I/II status. Our findings support a possible role of androgens in ovarian carcinogenesis. Additional studies exploring this association are needed. What's new? There appear to be several types of epithelial invasive ovarian cancer (EOC), and hormone-related risk factors are poorly understood. In this study, the authors found that the impact of endogenous androgens on the risk of developing EOC differed depending upon tumor characteristics. Androgen concentrations were positively associated with the risk of low-grade and type-I carcinomas, but the study found an inverse association for high-grade tumors. These findings support a possible role for androgens in ovarian carcinogenesis, and emphasize the need for additional research.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a ovarian carcinoma
653 a endogenous androgens
653 a histologic subtype
653 a androstenedione
653 a type I tumors
653 a type II tumors
653 a ovarian carcinoma
7001 a Fortner, Renee T.4 aut
7001 a Rinaldi, Sabina4 aut
7001 a Schock, Helena4 aut
7001 a Overvad, Kim4 aut
7001 a Tjonneland, Anne4 aut
7001 a Hansen, Louise4 aut
7001 a Dossus, Laure4 aut
7001 a Fournier, Agnes4 aut
7001 a Baglietto, Laura4 aut
7001 a Romieu, Isabelle4 aut
7001 a Kuhn, Elisabetta4 aut
7001 a Boeing, Heiner4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Lagiou, Pagona4 aut
7001 a Trichopoulos, Dimitrios4 aut
7001 a Palli, Domenico4 aut
7001 a Masala, Giovanna4 aut
7001 a Sieri, Sabina4 aut
7001 a Tumino, Rosario4 aut
7001 a Sacerdote, Carlotta4 aut
7001 a Mattiello, Amalia4 aut
7001 a Ramon Quiros, Jose4 aut
7001 a Obon-Santacana, Mireia4 aut
7001 a Larranaga, Nerea4 aut
7001 a Chirlaque, Maria-Dolores4 aut
7001 a Sanchez, Maria-Jose4 aut
7001 a Barricarte, Aurelio4 aut
7001 a Peeters, Petra H.4 aut
7001 a Bueno-de-Mesquita, H. B(as)4 aut
7001 a Onland-Moret, N. Charlotte4 aut
7001 a Brändstedt, Jennyu Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-jyb
7001 a Lundin, Evau Umeå universitet,Patologi,Enheten för biobanksforskning4 aut0 (Swepub:umu)evlu0001
7001 a Idahl, Annikau Umeå universitet,Obstetrik och gynekologi,Näringsforskning,Enheten för biobanksforskning4 aut0 (Swepub:umu)anid0002
7001 a Weiderpass, Elisabeteu Karolinska Institutet4 aut
7001 a Gram, Inger T.4 aut
7001 a Lund, Eiliv4 aut
7001 a Kaw, Kay-Tee4 aut
7001 a Travis, Ruth C.4 aut
7001 a Merritt, Melissa A.4 aut
7001 a Gunther, Marc J.4 aut
7001 a Riboli, Elio4 aut
7001 a Kaaks, Rudolf4 aut
7102 a Patologi, Malmöb Forskargrupper vid Lunds universitet4 org
7730 t International Journal of Cancerd : Wileyg 136:2, s. 399-410q 136:2<399-410x 0020-7136x 1097-0215
8564 u http://dx.doi.org/10.1002/ijc.29000y FULLTEXT
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.29000
8564 8u https://lup.lub.lu.se/record/4871917
8564 8u https://doi.org/10.1002/ijc.29000
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-97271
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:130099714

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