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FältnamnIndikatorerMetadata
00005621naa a2200529 4500
001oai:DiVA.org:kth-242751
003SwePub
008190213s2016 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2427512 URI
0247 a https://doi.org/10.1109/nssmic.2016.80695302 DOI
040 a (SwePub)kth
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a kon2 swepub-publicationtype
1001 a Borrazzo, Cristianu Sapienza Univ Rome, Dept Mol Med, Rome, Italy.4 aut
2451 0a PET and MRI-guided focused ultrasound surgery for Neurological Applications
264 1b IEEE,c 2016
338 a print2 rdacarrier
500 a QC 20190213
520 a Magnetic Resonance (MR) guided Focused Ultrasound Surgery (MRgFUS) technology, combined with High Intensity Focused Ultrasound (HIFU) beams, has opened to new therapeutic protocols for various pathological conditions. The success of this therapy relies on the accuracy of the guidance for therapy provided by thermal mapping of sonication, which is obtained with MR imaging. In addition, in recent years, multimodality Positron Emission Tomography and Magnetic Resonance Imaging (PET/MRI) imaging has been developed. This technique is able to provide simultaneous functional and soft tissue morphological imaging and, for this reason, it is particularly engaging for brain imaging. The key concept behind this work is to assess the feasibility of a brain-dedicated PET-and MRI-guided FUS device providing real-time evaluation of the outcome of the HIFU therapy. At first, a method to improve imaging capabilities of small-ring PET scanners will be presented. It will be showed that thanks to this method it is possible to obtain high tomographic spatial resolution with an affordable, brain-dedicated, PET scanner based on monolithic scintillation crystals and able to work as an insert in a MRI system. Moreover, simulations of an anthropomorphic phantom will be made in order to evaluate the effect of different HIFU protocols and, in addition, to investigate the capability of thermal maps provided by MRI for assessing the effect of the HIFU treatment. Finally, from the comparison of the spatial resolutions provided by each imaging technique (PET, MRI and thermal MRI) and the HIFU therapy, it will be possible to assess the feasibility of the proposed multimodality device. The system suggested in this work should be composed of a MRI scanner with a PET insert and a customized MRI-compatible focused ultrasound applicator. It could be very useful for the diagnosis and therapy of brain tumors thanks to the possibility of a real-time evaluation of the effect of the HIFU treatment. The protocol for the therapy could be executed in three main steps: the diagnosis of the pathological condition by means of fused anatomical imaging from MRI and functional imaging from PET (with different radiotracers) that allow to identify the region where apply the therapy, the ablation of the tumor by means of HIFU beams and the simultaneous evaluation of the thermal response of the tissues by means MRI thermal maps and, finally, the assessment of the outcome of the therapy by means, again, of PET/MRI hybrid imaging. The results suggest that PET and MRI-guided focused ultrasound surgery (PET/MRgFUS) could be an innovative, feasible and engaging technique for tumor ablation in the brain.
650 7a TEKNIK OCH TEKNOLOGIERx Medicinteknik0 (SwePub)2062 hsv//swe
650 7a ENGINEERING AND TECHNOLOGYx Medical Engineering0 (SwePub)2062 hsv//eng
653 a Brain imaging
653 a Focused Ultrasoung Surgery
653 a High Intensity Focused Ultrasound
653 a Magnetic Resonance
653 a Multimodality imaging
653 a PET/MRI guided FUS
653 a Positron Emission Tomography
7001 a Preziosi, Enricou Sapienza Univ Rome, Dept Mol Med, Rome, Italy.;Sapienza Univ Rome, SAIMLAL Dept, Morphofunct Sci, Rome, Italy.4 aut
7001 a Borasi, Giovanniu Univ Milan, Dept Mol Bioimaging & Phys, Milan, Italy.4 aut
7001 a Bettiol, Marcou Sapienza Univ Rome, Dept Mol Med, Rome, Italy.4 aut
7001 a Sanchez, Sebastianu CSIC, I3M, Valencia, Spain.4 aut
7001 a Carni, Marcou Policlin Umberto 1, Med Phys Unit, Rome, Italy.4 aut
7001 a di Castro, Elisabettau Sapienza Univ Rome, Dept Mol Med, Rome, Italy.;Policlin Umberto 1, Med Phys Unit, Rome, Italy.4 aut
7001 a Gonzalez, Antonio J.u CSIC, I3M, Valencia, Spain.4 aut
7001 a Bennati, Paolou KTH,Skolan för kemi, bioteknologi och hälsa (CBH)4 aut0 (Swepub:kth)u1ua4ia4
7001 a Gonzalez-Montoro, Andreau CSIC, I3M, Valencia, Spain.4 aut
7001 a Napoli, Alessandrou Sapienza Univ Rome, Dept Radiol Sci Oncol & Anat Pathol, Rome, Italy.4 aut
7001 a Pellegrini, Rosannau Sapienza Univ Rome, Dept Mol Med, Rome, Italy.4 aut
7001 a Pani, Robertou Sapienza Univ Rome Italy, Dept Medicosurg Sci & Biotechnol, Rome, Italy.4 aut
7102 a Sapienza Univ Rome, Dept Mol Med, Rome, Italy.b Sapienza Univ Rome, Dept Mol Med, Rome, Italy.;Sapienza Univ Rome, SAIMLAL Dept, Morphofunct Sci, Rome, Italy.4 org
7730 t 2016 IEEE NUCLEAR SCIENCE SYMPOSIUM, MEDICAL IMAGING CONFERENCE AND ROOM-TEMPERATURE SEMICONDUCTOR DETECTOR WORKSHOP (NSS/MIC/RTSD)d : IEEEz 9781509016426
8564 u https://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=8062961y conference
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-242751
8564 8u https://doi.org/10.1109/nssmic.2016.8069530

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